Search results for "31"
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Different sitting positions influence cross country sit skiers performance : Sitting position influence on force generation and cycle characteristics
2018
Cross country sit skiing is a Paralympic discipline in which athletes due to physical impairment ski sitting on a sit-ski. The impairment influences performance directly and also through sitting position. Athletes with a better trunk control usually adopt a sitting position called “kneeing” in which the hip joints are higher than the knee joints. In contrast, athletes with high impact of impairment prefer a sitting position called “knee high” in which the hip joints are lower than the knee joints. Able bodied athletes skiing on the ergometer in these two sitting positions showed different performance. However, to the best of authors’ knowledge, no studies have examined performance, force pr…
MUSCLE BIOENERGETIC ABNORMALITY IN MYOTONIC-DYSTROPHY - A SECONDARY MITOCHONDRIAL DISORDER
1993
International audience; Abstract: The thenar muscles and gastrocnemius of a patient with myotonic dystrophy were investigated, at rest, by phosphorus nuclear magnetic resonance spectroscopy. A decrease in phosphocreatine level and an increase in inorganic phosphate and phosphodiester levels were found in the gastrocnemius, which was clinically spared, whilst the thenar muscles, which were wasted and affected by myotonia, exhibited only an increased inorganic phosphate level and an elevated pH. These findings were comparable with those found in other muscular disorders, such as Duchenne's and Becker's dystrophies, as well as in limb girdle dystrophy. They suggested that the abnormalities obs…
Effect of Training-Induced Changes in Achilles Tendon Stiffness on Muscle–Tendon Behavior During Landing
2018
During rapid deceleration of the body, tendons buffer part of the elongation of the muscle–tendon unit (MTU), enabling safe energy dissipation via eccentric muscle contraction. Yet, the influence of changes in tendon stiffness within the physiological range upon these lengthening contractions is unknown. This study aimed to examine the effect of training-induced stiffening of the Achilles tendon on triceps surae muscle–tendon behavior during a landing task. Twenty-one male subjects were assigned to either a 10-week resistance-training program consisting of single-leg isometric plantarflexion (n = 11) or to a non-training control group (n = 10). Before and after the training period, plantarf…
Pathogenesis of polymyalgia rheumatica
2018
Polymyalgia rheumatica (PMR) is a chronic, inflammatory disorder of unknown cause, almost exclusively occurring in people aged over 50 and often associated with giant cell arteritis. The evidence that PMR occurs almost exclusively in individuals aged over 50 may indicate that age-related immune alterations in genetically predisposed subjects contribute to development of the disease. Several infectious agents have been investigated as possible triggers of PMR even though the results are inconclusive. Activation of the innate and adaptive immune systems has been proved in PMR patients as demonstrated by the activation of dendritic cells and monocytes/macrophages and the altered balance betwee…
Giant cell arteritis associated with chronic active Epstein-Barr virus infection
2013
Giant cell arteritis is an inflammatory vasculopathy that preferentially affects medium-sized and large arteries. A viral cause has been suspected but not confirmed in polymyalgia rheumatica and giant-cell arteritis. We report the case of a 81-year-old female who suffered from chronic active Epstein-Barr virus infection and developed giant cell temporal arteritis.
mRNA expression profiles of primary high-grade central osteosarcoma are preserved in cell lines and xenografts
2011
Abstract Background Conventional high-grade osteosarcoma is a primary malignant bone tumor, which is most prevalent in adolescence. Survival rates of osteosarcoma patients have not improved significantly in the last 25 years. Aiming to increase this survival rate, a variety of model systems are used to study osteosarcomagenesis and to test new therapeutic agents. Such model systems are typically generated from an osteosarcoma primary tumor, but undergo many changes due to culturing or interactions with a different host species, which may result in differences in gene expression between primary tumor cells, and tumor cells from the model system. We aimed to investigate whether gene expressio…
Training-induced increase in Achilles tendon stiffness affects tendon strain pattern during running
2019
Background During the stance phase of running, the elasticity of the Achilles tendon enables the utilisation of elastic energy and allows beneficial contractile conditions for the triceps surae muscles. However, the effect of changes in tendon mechanical properties induced by chronic loading is still poorly understood. We tested the hypothesis that a training-induced increase in Achilles tendon stiffness would result in reduced tendon strain during the stance phase of running, which would reduce fascicle strains in the triceps surae muscles, particularly in the mono-articular soleus. Methods Eleven subjects were assigned to a training group performing isometric single-leg plantarflexion co…
Who enjoys listening to sad music and why?
2011
although people generally avoid negative emotional experiences in general, they often enjoy sadness portrayed in music and other arts. The present study investigated what kinds of subjective emotional experiences are induced in listeners by sad music, and whether the tendency to enjoy sad music is associated with particular personality traits. One hundred forty-eight participants listened to 16 music excerpts and rated their emotional responses. As expected, sadness was the most salient emotion experienced in response to sad excerpts. However, other more positive and complex emotions such as nostalgia, peacefulness, and wonder were also evident. Furthermore, two personality traits – Opennes…
Videopelien musiikin tutkimus
2022
Tämä Musiikki-lehden teemanumero on ensimmäinen suomenkielinen antologia, joka kokoaa yhteen maassamme tehtävää pelimusiikin tutkimusta. Miksi tällainen julkaisu vuonna 2022? Erikoisnumeron ajoitusta voi näkökulmasta riippuen pitää kieltämättä yhtä hyvin joko aikaisena tai myöhäisenä. Aikainen julkaisu on sikäli, että pelimusiikin tutkimus ei ole vielä tätä tekstiä kirjoittaessamme erityisen vakiintunut tutkimusala Suomessa, puhuttiin sitten musiikkitieteen tai muiden lähialojen piirissä tehtävästä tutkimuksesta. Yksi tämän erikoisnumeron tavoitteita olikin tarjota Suomessa toimiville tutkijoille julkaisualusta ja hahmottaa sen kautta, millaisena alan tutkimus maassamme tällä hetkellä piirt…
Recaída locorregional en mujeres con cáncer de mama portadoras de mutación BRCA tratadas mediante cirugía conservadora
2015
El cáncer de mama (CM) representa la quinta causa de muerte por cáncer en todo el mundo y la segunda en los países desarrollados. El conocimiento de los factores de riesgo que predisponen a padecerlo permite poder desarrollar una prevención primaria y secundaria adecuada, con el fin de disminuir la incidencia de CM en el primer caso y realizar un diagnóstico precoz en el segundo. Entre un 5-10% de los casos de CM presentan una causa hereditaria asociándose a mutaciones principalmente en los genes BRCA1 y BRCA2 ocasionando el conocido Síndrome de CM y cáncer de Ovario (CO) Hereditario. Las personas portadoras de estas alteraciones presentan un alto riesgo de padecer CM , que oscila entre el …