Search results for "33"

Identification of progenitor cancer stem cell in lentigo maligna melanoma.

2008

:  The potential role of stem cells in neoplasia has aroused considerable interest over the past few years. A number of known biologic characteristics of melanomas support the theory that they may originate in a mutated stem cell. Melanocytic stem cell markers have been described recently. Moreover, the CD133 cells that show surface markers for CD34 are stem cells primitive. These stem cells are capable of differentiating into neurons, glia, keratinocytes, smooth muscle cells, and melanocytes in vitro. The identification of cancer stem/initiating cells with a crucial role in tumor formation may open up new pharmacologic perspectives. The purpose of this study is to detect the expression of …

Pathobiology of Hodgkin Lymphoma

2010

Despite its well-known histological and clinical features, Hodgkin's lymphoma (HL) has recently been the object of intense research activity, leading to a better understanding of its phenotype, molecular characteristics, histogenesis, and possible mechanisms of lymphomagenesis. There is complete consensus on the B-cell derivation of the tumor in most cases, and on the relevance of Epstein-Barr virus infection and defective cytokinesis in at least a proportion of patients. The REAL/WHO classification recognizes a basic distinction between lymphocyte predominance HL (LP-HL) and classic HL (cHL), reflecting the differences in clinical presentation and behavior, morphology, phenotype, and molec…

Differential Gene Expression of Medullary Thyroid Carcinoma Reveals Specific Markers Associated with Genetic Conditions

2013

Maliszewska, Agnieszka et al.

Splenomegaly Impacts Prognosis in Essential Thrombocythemia and Polycythemia Vera: A Single Center Study

2019

Splenomegaly is one of the major clinical manifestations of primary myelofibrosis and is common also in other chronic Philadelphia-negative myeloproliferative neoplasms, causing symptoms and signs and affecting quality of life of patients diagnosed with these diseases. We aimed to study the impact that such alteration has on thrombotic risk and on the survival of patients with essential thrombocythemia and patients with Polycythemia Vera (PV). We studied the relationship between splenomegaly (and its grade), thrombosis and survival in 238 patients with et and 165 patients with PV followed at our center between January 1997 and May 2019.

Nonsense-mediated decay mechanism is a possible modifying factor of clinical outcome in nonsense cd39 beta thalassemia genotype

2012

Nonsense-mediated mRNA decay (NMD) is a surveillance system to prevent the synthesis of non-functional proteins. In β-thalassemia, NMD may have a role in clinical outcome. An example of premature translation stop codons appearing for the first time is the β-globin cd39 mutation; when homozygous, this results in a severe phenotype. The aim of this study was to determine whether the homozygous nonsense cd39 may have a milder phenotype in comparison with IVS1,nt110/cd39 genotype. Genotypes have been identified from a cohort of 568 patients affected by β-thalassemia. These genotypes were compared with those found in 577 affected fetuses detected among 2292 prenatal diagnoses. The…

El Rey Don Pedro de Castilla, el Justiciero

Caplletra ornada. Sign.: A-E4. Text amb postil·les marginals. Reclams.

Eventually periodic solutions of single neuron model

2020

In this paper, we consider a nonautonomous piecewise linear difference equation that describes a discrete version of a single neuron model with a periodic (period two and period three) internal decay rate. We investigated the periodic behavior of solutions relative to the periodic internal decay rate in our previous papers. Our goal is to prove that this model contains a large quantity of initial conditions that generate eventually periodic solutions. We will show that only periodic solutions and eventually periodic solutions exist in several cases.

The effects of populism as a social identity frame on persuasion and mobilization: evidence from a 15-country experiment

2020

This article investigates the impact of populist messages on issue agreement and readiness for action in 15 countries (N = 7,286). Specifically, populist communicators rely on persuasive strategies by which social group cues become more salient and affect people's judgment of and political engagement with political issues. This strategy is called ‘populist identity framing’ because the ordinary people as the in‐group is portrayed as being threatened by various out‐groups. By blaming political elites for societal or economic problems harming ordinary people, populist communicators engage in anti‐elitist identity framing. Another strategy is to blame immigrants for social problems – that is, …

Mast cell-derived mediators promote murine neutrophil effector functions

2013

Mast cells are able to trigger life-saving immune responses in murine models for acute inflammation. In such settings, several lines of evidence indicate that the rapid and protective recruitment of neutrophils initiated by the release of mast cell-derived pro-inflammatory mediators is a key element of innate immunity. Herein, we investigate the impact of mast cells on critical parameters of neutrophil effector function. In the presence of activated murine bone marrow-derived mast cells, neutrophils freshly isolated from bone marrow rapidly lose expression of CD62L and up-regulate CD11b, the latter being partly driven by mast cell-derived TNF and GM-CSF. Mast cells also strongly enhance neu…

EU transition in power sector: How RES affects the design and operations of transmission power systems

2019

In the past, much of Europe's electricity grid network has been designed in consideration of the locations of conventional generation plants. However, a large share of today's renewables production – notably variable wind and solar – does not correspond to this grid architecture. Interconnectors, in addition to internal infrastructure, are key to creating new electricity corridors to connect areas of surplus to areas of scarcity. In this context, in 2014 the European Council, in recognizing that a fundamental role of transmission infrastructure is to enable the integration of areas of high renewable energy potential with main consumption areas, endorsed the proposal by the European Commissi…