Search results for "33"
showing 10 items of 1917 documents
Inversión extranjera directa OCDE-Argentina: un análisis de sus factores determinantes y su relación con los flujos comerciales
2003
Los flujos de Inversión Extranjera Directa (IED) mundiales presentan un crecimiento espectacular durante la década de los 90 del pasado siglo XX, con tasas anuales acumulativas del orden del 35%-45%. Los países en desarrollo, por su parte, han venido captando alrededor de un 30% del total de estos flujos, mientras, en su seno, los denominados países emergentes, países más dinámicos de Latinoamérica y el Sudeste Asiático, acumulan alrededor del 90% de dichas entradas. En este contexto, la ampliación del conocimiento de los factores que están impulsando el crecimiento de los flujos de IED entre países desarrollados y países en desarrollo es el objetivo general de la presente Tesis Doctoral. N…
Self-phase modulation-based 2R regenerator including pulse compression and offset filtering for 42.6 Gbit/s RZ-33% transmission systems
2009
International audience; We report on the experimental and theoretical study of a self-phase-modulation-based regenerator at 42.6 Gbit/s with a return-to-zero 33% format. We point out some detrimental effects such as intrachannel interactions and Brillouin scattering. An efficient solution, relying on a self-phase-modulation-based pulse compressor in combination with the regenerator, is proposed to overcome these detrimental phenomena. The experimental demonstration shows the effectiveness of a wavelength-transparent regenerator at 42.6 Gbit/s with a sensitivity-improvement of more than 5 dB and an eye-opening improvement of 2.3 dB in a back-to-back configuration, as well as a 10 times maxim…
Cancer stem cell analysis and clinical outcome in patients with glioblastoma multiforme
2008
Abstract Purpose: Cancer stem cells (CSC) are thought to represent the population of tumorigenic cells responsible for tumor development. The stem cell antigen CD133 identifies such a tumorigenic population in a subset of glioblastoma patients. We conducted a prospective study to explore the prognostic potential of CSC analysis in glioblastoma patients. Experimental Design: We investigated the relationship between the in vitro growth potential of glioblastoma CSCs and patient death or disease progression in tumors of 44 consecutive glioblastoma patients treated with complete or partial tumorectomy followed by radiotherapy combined with temozolomide treatment. Moreover, we evaluated by immun…
The mTOR Inhibitor Temsirolimus Added to Rituximab Combined With Dexamethasone, Cytarabine, and Cisplatinum (R-DHAP) for the Treatment of Patients Wi…
2021
There is a high need for novel treatment options in relapsed and refractory diffuse large B-cell lymphoma. Single agent mammalian target of rapamycin (mTOR) inhibitor treatment has shown promising efficacy in this entity. Here, we report on the results of the mTOR-inhibitor temsirolimus combined to standard rituximab-DHAP salvage regimen in a prospective, multicenter, phase II, open-label study. The STORM regimen consisted of rituximab 375 mg/m(2) (day 2) and DHAP (dexamethasone 40 mg day 3-6, cisplatinum 100 mg/m(2) day 3, cytarabine 2 × 2 g/m(2) day 4) with temsirolimus added on day 1 and 8 of a 21-day cycle, with 2 to 4 cycles planned. In part I, dose levels of 25, 50, 75, and 100 mg fo…
CD133 as a target for colon cancer.
2012
INTRODUCTION: Recent evidence based on cancer stem cell (CSC) models, is boosting the progress of translational research and providing relevant clinical implications in many tumour types, including colorectal cancer. The current failure of standard therapies is attributed to a small fraction of the primary cell population with stem-like characteristics, such as self-renewal and differentiation. Identification of CSCs is based on two different criteria of selection: stemness-selective conditions and direct isolation based on putative stem cell markers expression. CD133, a transmembrane glycoprotein, was associated with tumor-initiating cells derived from several histological variants of tumo…
Myeloid and T-Cell Microenvironment Immune Features Identify Two Prognostic Sub-Groups in High-Grade Gastroenteropancreatic Neuroendocrine Neoplasms
2021
High-grade Gastroenteropancreatic Neuroendocrine neoplasms (H-NENs) comprehend well-differentiated tumors (NET G3) and poorly differentiated carcinomas (NEC) with proliferative activity indexes as mitotic count (MC) >
Navigating high-choice European political information environments : a comparative analysis of news user profiles and political knowledge
2021
The transition from low- to high-choice media environments has had far-reaching implications for citizens’ media use and its relationship with political knowledge. However, there is still a lack of comparative research on how citizens combine the usage of different media and how that is related to political knowledge. To fill this void, we use a unique cross-national survey about the online and offline media use habits of more than 28,000 individuals in 17 European countries. Our aim is to (i) profile different types of news consumers and (ii) understand how each user profile is linked to political knowledge acquisition. Our results show that five user profiles – news minimalists, social m…
An Agenda for Open Science in Communication
2021
Contains fulltext : 226720.pdf (Publisher’s version ) (Open Access) In the last 10 years, many canonical findings in the social sciences appear unreliable. This so-called "replication crisis" has spurred calls for open science practices, which aim to increase the reproducibility, replicability, and generalizability of findings. Communication research is subject to many of the same challenges that have caused low replicability in other fields. As a result, we propose an agenda for adopting open science practices in Communication, which includes the following seven suggestions: (1) publish materials, data, and code; (2) preregister studies and submit registered reports; (3) conduct replicatio…
Optimal Power Flow in three-phase islanded microgrids with inverter interfaced units
2015
In this paper, the solution of the Optimal Power Flow (OPF) problem for three phase islanded microgrids is studied, the OPF being one of the core functions of the tertiary regulation level for an AC islanded microgrid with a hierarchical control architecture. The study also aims at evaluating the contextual adjustment of the droop parameters used for primary voltage and frequency regulation of inverter interfaced units. The work proposes a mathematical method for the OPF solution also considering the droop parameters as variables. The output of the OPF provides an iso-frequential operating point for all the generation units and a set of droop parameters for primary regulation. In this way, …
Improved primary regulation for minimum energy losses in islanded microgrids
2017
In this paper, an improved primary regulation is proposed for grid forming units supplying islanded microgrids. A minimum losses Optimal Power Flow is run off-line to devise the operating set points composing the primary regulation curve. In this way, after load perturbations, generators can reach an optimized operating point for a given and unique minimum losses energy flows distribution. The idea is to skip the hierarchical control architecture and provide a feasible and optimized operating point. A case study over 24 hours shows the effectiveness of this new approach as well as the improved operation quality of the system.