Search results for "34"
showing 10 items of 1830 documents
HSP27: A Therapeutic Target in Myelofibrosis
2016
Abstract Myelofibrosis (MF) is the most aggressive myeloproliferative neoplasms (MPN) with the highest degree of morbidity and mortality, including progressive bone marrow fibrosis resulting into bone marrow failure. JAK2 kinase inhibitors have been successfully used for a few years in MPN and more particularly for MF treatment. Despite their beneficial effects on spleen size and symptoms, JAK2 inhibitors induce low molecular and survival responses underscoring the urgent need for other therapeutic approaches. Recently, heat shock protein 90 (HSP90) - known to stabilize JAK2 - has been reported as a promising therapeutic target in MPN. However HSP90 inhibitors show toxicity and induce the e…
Efficient, non-toxic anion transport by synthetic carriers in cells and epithelia.
2016
Transmembrane anion transporters (anionophores) have potential for new modes of biological activity, including therapeutic applications. In particular they might replace the activity of defective anion channels in conditions such as cystic fibrosis. However, data on the biological effects of anionophores are scarce, and it remains uncertain whether such molecules are fundamentally toxic. Here, we report a biological study of an extensive series of powerful anion carriers. Fifteen anionophores were assayed in single cells by monitoring anion transport in real time through fluorescence emission from halide-sensitive yellow fluorescent protein. A bis-(p-nitrophenyl)ureidodecalin shows especial…
Zvaigžņotā Debess: 2007, Rudens
2007
Latvijas Zinātnes padome, Latvijas Universitāte
Darboux systems with a cusp point and pseudo-abelian integrals
2018
International audience; We study pseudo-abelian integrals associated with polynomial deformations of Darboux systems having a cuspidal singularity. Under some genericity hypothesis we provide locally uniform boundedness of on the number of their zeros.
Unfolding of saddle-nodes and their Dulac time
2016
Altres ajuts: UNAB10-4E-378, co-funded by ERDF "A way to build Europe" and by the French ANR-11-BS01-0009 STAAVF. In this paper we study unfoldings of saddle-nodes and their Dulac time. By unfolding a saddle-node, saddles and nodes appear. In the first result (Theorem A) we give a uniform asymptotic expansion of the trajectories arriving at the node. Uniformity is with respect to all parameters including the unfolding parameter bringing the node to a saddle-node and a parameter belonging to a space of functions. In the second part, we apply this first result for proving a regularity result (Theorem B) on the Dulac time (time of Dulac map) of an unfolding of a saddle-node. This result is a b…
Embedding mapping class groups of orientable surfaces with one boundary component
2012
We denote by $S_{g,b,p}$ an orientable surface of genus $g$ with $b$ boundary components and $p$ punctures. We construct homomorphisms from the mapping class groups of $S_{g,1,p}$ to the mapping class groups of $S_{g',1,(b-1)}$, where $b\geq 1$. These homomorphisms are constructed from branched or unbranched covers of $S_{g,1,0}$ with some properties. Our main result is that these homomorphisms are injective. For unbranched covers, this construction was introduced by McCarthy and Ivanov~\cite{IM}. They proved that the homomorphisms are injective. A particular cases of our embeddings is a theorem of Birman and Hilden that embeds the braid group on $p$ strands into the mapping class group of …
Constrained differential inclusions with nonlocal initial conditions
2017
International audience; We show existence for the perturbed sweeping process with nonlocal initial conditions under very general hypotheses. Periodic, anti-periodic, mean value and multipoints conditions are included in this study. We give abstract results for differential inclusions with nonlocal initial conditions through bounding functions and tangential conditions. Some applications to differential complementarity systems and to vector hysteresis are given.
Characterization of the Clarke regularity of subanalytic sets
2017
International audience; In this note, we will show that for a closed subanalytic subset $A \subset \mathbb{R}^n$, the Clarke tangential regularity of $A$ at $x_0 \in A$ is equivalent to the coincidence of the Clarke's tangent cone to $A$ at $x_0$ with the set \\$$\mathcal{L}(A, x_0):= \bigg\{\dot{c}_+(0) \in \mathbb{R}^n: \, c:[0,1]\longrightarrow A\;\;\mbox{\it is Lipschitz}, \, c(0)=x_0\bigg\}.$$Where $\dot{c}_+(0)$ denotes the right-strict derivative of $c$ at $0$. The results obtained are used to show that the Clarke regularity of the epigraph of a function may be characterized by a new formula of the Clarke subdifferential of that function.
Differential inclusions involving normal cones of nonregular sets in Hilbert spaces
2017
This thesis is dedicated to the study of differential inclusions involving normal cones of nonregular sets in Hilbert spaces. In particular, we are interested in the sweeping process and its variants. The sweeping process is a constrained differential inclusion involving normal cones which appears naturally in several applications such as elastoplasticity, electrical circuits, hysteresis, crowd motion, etc.This work is divided conceptually in three parts: Study of positively alpha-far sets, existence results for differential inclusions involving normal cones and characterizations of Lyapunov pairs for the sweeping process. In the first part (Chapter 2), we investigate the class of positivel…
Fractal Weyl law for open quantum chaotic maps
2014
We study the semiclassical quantization of Poincar\'e maps arising in scattering problems with fractal hyperbolic trapped sets. The main application is the proof of a fractal Weyl upper bound for the number of resonances/scattering poles in small domains near the real axis. This result encompasses the case of several convex (hard) obstacles satisfying a no-eclipse condition.