Search results for "35"
showing 10 items of 2413 documents
On-chip frequency combs and telecommunications signal processing meet quantum optics
2018
Entangled optical quantum states are essential towards solving questions in fundamental physics and are at the heart of applications in quantum information science. For advancing the research and development of quantum technologies, practical access to the generation and manipulation of photon states carrying significant quantum resources is required. Recently, integrated photonics has become a leading platform for the compact and cost-efficient generation and processing of optical quantum states. Despite significant advances, most on-chip nonclassical light sources are still limited to basic bi-photon systems formed by two-dimensional states (i.e., qubits). An interesting approach bearing …
A quasiconformal composition problem for the Q-spaces
2017
Given a quasiconformal mapping $f:\mathbb R^n\to\mathbb R^n$ with $n\ge2$, we show that (un-)boundedness of the composition operator ${\bf C}_f$ on the spaces $Q_{\alpha}(\mathbb R^n)$ depends on the index $\alpha$ and the degeneracy set of the Jacobian $J_f$. We establish sharp results in terms of the index $\alpha$ and the local/global self-similar Minkowski dimension of the degeneracy set of $J_f$. This gives a solution to [Problem 8.4, 3] and also reveals a completely new phenomenon, which is totally different from the known results for Sobolev, BMO, Triebel-Lizorkin and Besov spaces. Consequently, Tukia-V\"ais\"al\"a's quasiconformal extension $f:\mathbb R^n\to\mathbb R^n$ of an arbitr…
The impact of study design and diagnostic approach in a large multi-centre ADHD study. Part 1: ADHD symptom patterns
2011
Contains fulltext : 96439.pdf (Publisher’s version ) (Open Access) BACKGROUND: The International Multi-centre ADHD Genetics (IMAGE) project with 11 participating centres from 7 European countries and Israel has collected a large behavioural and genetic database for present and future research. Behavioural data were collected from 1068 probands with the combined type of attention deficit/hyperactivity disorder (ADHD-CT) and 1446 'unselected' siblings. The aim was to analyse the IMAGE sample with respect to demographic features (gender, age, family status, and recruiting centres) and psychopathological characteristics (diagnostic subtype, symptom frequencies, age at symptom detection, and com…
Open innovation: A real option to restore value to the biopharmaceutical R&D
2014
The pharmaceutical landscape has changed, and new business models, based on alliances, are increasingly being adopted in this industry. Biotechnology advances have pushed this development, and pooling complementary resources coming from incumbents and newcomers is a key skill to succeed: these are the premises for a quick spread of the open innovation (OI) paradigm in this industry. R&D portfolio selection needs R&D project evaluation, and Real Options Analysis (ROA) is acknowledged as a powerful tool to evaluate uncertain projects that have an intrinsic flexibility. The present research aims to foster the use of ROA in the OI field in order to encourage firms to undertake this innovation mode…
A real options based model to select a balanced R&D portfolio
2011
The R&D process in the pharmaceutical industry has a long and dynamic life then it is an ideal field of application for ROA. Actually, ROA implementation, as widely demonstrated in literature, is narrowed to very limited cases because its perceived complexity. This research wants to suggest a simplified method, respect the ones available in literature, that could foster the use of ROA: we built up an integer linear programming model, based on a model available in literature, useful for selecting a balanced R&D portfolio from a set of candidate drugs. The model has been tested through a case study.
An affordable way to implement real options to select optimal R&D portfolio
2011
Real option Analysis (ROA) is acknowledged as a powerful tool to evaluate uncertain projects whose uncertainty depends heavily on alternatives available along the project life. The R&D process in the pharmaceutical industry has a long and dynamic life then it is an ideal field of application for ROA. Actually, ROA implementation, as widely demonstrated in literature, is narrowed to very limited cases because its perceived complexity. This research wants to suggest a simplified method, respect the ones available in literature, that could foster the use of ROA: we built up an integer linear programming model, based on a model available in literature, useful for selecting the optimal R&D produ…
A real options based support system to open innovation
2012
Pharmaceutical R&D process (PR&DP) has been deeply investigated by different streams of literature; the interest is due to the strategic implication of the related decisions undertaken. The PR&DP has been revolutionised by the biotech advent and as a consequence R&D managers cannot avoid to consider Open Innovation paradigm during this decision process. Starting from a Real Option optimization model available in literature, the paper aims at proposing a decision support system (DSS) able to suggest the candidate products to be included in the best R&D portfolio varying input parameters (resilient products), to provide a products Pareto analysis that aims at individuating the products for wh…
Role of collaborative supply chain of innovation in firm’s performance
2014
This work depicts the Supply Chain of Innovation (SCoI) including only those kinds of relationships related to the purchase and selling of R&D commodities. The theoretical framework represents the propensity of a firm in improving its innovation performance thanks to its collaboration experience and positioning in SCoI. We validate our theoretical framework on a sample of 208 biotechnology companies involved in 814 SCoI agreements. Our results show the positive direct impact of SCoI collaboration experience on innovation performance and a mediating role of positioning in SCoI on the abovementioned link.
From Buildings' End of Life to Aggregate Recycling under a Circular Economic Perspective: A Comparative Life Cycle Assessment Case Study
2021
The demolition of buildings, apart from being energy intensive and disruptive, inevitably produces construction and demolition waste (C&Dw). Unfortunately, even today, the majority of this waste ends up underexploited and not considered as valuable resources to be re-circulated into a closed/open loop process under the umbrella of circular economy (CE). Considering the amount of virgin aggregates needed in civil engineering applications, C&Dw can act as sustainable catalyst towards the preservation of natural resources and the shift towards a CE. This study completes current research by presenting a life cycle inventory compilation and life cycle assessment case study of two buildin…