Search results for "38"
showing 10 items of 1730 documents
Hematopoietic stem cell quiescence and function are controlled by the CYLD–TRAF2–p38MAPK pathway
2015
Tesio at al. identify a novel pathway controlled by the tumor suppressor and deubiquitinase cylindromatosis (CYLD), which is involved in the regulation of hematopoietic stem cell quiescence and repopulation potential.
Traps o non Traps? Questo è il dilemma! Dati real life di una casistica con mutazione R92Q
2021
La Cova de Dalt del Tossal de la Font (Vilafamés, Castellón): conclusiones preliminares de las intervenciones arqueológicas (1982-1987 / 2004-2012)
2013
Resumen Las excavaciones llevadas a cabo en el yacimiento de la Cova de Dalt del Tossal de la Font en la década de 1980 pusieron al descubierto un importante relleno kárstico del Pleistoceno Superior. Entre el registro recuperado destacan, además de diversas especies de herbívoros y carnívoros, así como de un reducido conjunto litotécnico, tres fósiles humanos adscritos en términos generales al grupo de los neandertales. Entre 2004 y 2012, en el marco de un convenio entre la Universitat Jaume I de Castelló (UJI), el Servei d¿Investigacions Arqueològiques i Prehistòriques (SIAP) de la Diputació de Castelló y el Institut Català de Paleoecologia Humana i Evolució Social (IPHES), se ha desarrol…
The high-performance technology CRISPR/Cas9 improves knowledge and management of acute myeloid leukemia
2021
Knowledge on acute myeloid leukemia pathogenesis and treatment has progressed recently, but not enough to provide ideal management. Improving the prognosis of acute myeloid leukemia patients depends on advances in molecular biology for the detection of new therapeutic targets and the production of effective drugs. The CRISPR/Cas9 technology allows gene insertions and deletions and it is the first step in investigating the function of their encoded proteins. Thus, new experimental models have been developed and progress has been made in understanding protein metabolism, antitumor activity, leukemic cell maintenance, differentiation, growth, apoptosis, and self-renewal, the combined pathogene…
(Supplementary Table 1) 230Th/U results for stalagmite Cuba Grande (CG) from Pinar del Rio
2010
We present 22 U-series ages for a stalagmite from north-western Cuba based on multi-collector inductively coupled plasma mass spectrometry (MC-ICPMS) and thermal ionisation mass spectrometry (TIMS). Our results reveal that the stalagmite continuously grew within the last ~1400a. Low uranium content of the sample and thus, extremely low 230Th concentrations limit the precision and accuracy of 230Th/U-dating by TIMS. Samples measured by MC-ICPMS show a high variability of 232Th content along the growth axis with some sections significantly affected by initial 230Th from a detrital phase. An a-priori bulk earth ratio for (238U/232Th) cannot be used to accurately account for this initial 230Th.…
Thyroid dysfunction in pediatric patients with mild-moderate chronic renal insufficiency
2010
Enzymatically hydrolyzed low-density lipoprotein modulates inflammatory responses in endothelial cells
2009
SummaryThere is evidence that low-density lipoprotein (LDL) is modified by hydrolytic enzymes,and that the product (E-LDL) induces selective production of interleukin 8 (IL-8) in endothelial cells. Since nuclear factor-kappaB (NF-κB) is a major regulator of IL-8 transcription, we studied its activation in endothelial cells treated with E-LDL. Unexpectedly,the modified lipoprotein not only failed to activate NF-κB, but completely blocked its activation by tumour necrosis factor-alpha (TNF-α) in EA.hy926-cells, as assessed by electrophoretic mobility shift assays and immunofluorescence. Inhibition occurred upstream of NF-κB translocation, as inhibitor of NF-κB- (IκB)-phosphorylation was suppr…
Persistent episomal transgene expression in liver following delivery of a scaffold/matrix attachment region containing non-viral vector
2008
An ideal gene therapy vector should enable persistent transgene expression without limitations of safety and reproducibility. Here we report the development of a non-viral episomal plasmid DNA (pDNA) vector that appears to fulfil these criteria. This pDNA vector combines a scaffold/matrix attachment region (S/MAR) with a human liver-specific promoter (alpha1-antitrypsin (AAT)) in such a way that long-term expression is enabled in murine liver following hydrodynamic injection. Long-term expression is demonstrated by monitoring the longitudinal luciferase expression profile for up to 6 months by means of in situ bioluminescent imaging. All relevant control pDNA constructs expressing luciferas…
First measurement of the forward-backward charge asymmetry in top quark pair production
2008
We present the first measurement of the integrated forward-backward charge asymmetry in top-antitop quark pair (ttbar) production in proton-antiproton collisions in the lepton plus jets final state. Using a b-jet tagging algorithm and kinematic reconstruction assuming ttbar+X production and decay, a sample of 0.9fb-1 of data, collected by the D0 experiment at the Fermilab Tevatron Collider, is used to measure the asymmetry for different jet multiplicities. The result is also used to set upper limits on ttbar+X production via a Z' resonance.
Carta de Don Gregorio Mayàns i Siscàr escrita al Doctor Don Vicente Calatayud, Presbítero de la Congregación del Oratorio de San Felipe Neri de Valen…
1760
Grav. xil. a la port. amb la legenda "Omnia et in omnibus" Caplletra grav. Sign.: [ ]2, A-F4, G1. - Reclams