Search results for "38"

Increased percentages of calprotectin and TNF-Α double-positive monocytes in the acute phase of Kawasaki disease

2011

Background The acute phase of KD is characterized by a deficiency of suppressor T cells, marked activation of the immune system and increased secretion of cytokines by immune effector cells. Moreover, it has been shown that myeloid-related protein (MRP-8 and MRP-14) and S100proteins, the major calcium-binding proteins secreted by activated neutrophils and monocytes, contribute to cause inflammation in acute lesions of KD, and indeed one of the more common hematological alteration in KD is the increase of peripheral blood monocytes. Calprotectin, one of the major calcium-binding proteins, can lead to direct and indirect effects that result not only in inflammation but also in modification of…

A physical activity program dedicated to adolescents

2014

Adolescence is a life stage in which the development of individuality and self-identity occurs. The recent study of the SIP evaluated the life style in adolescents, highlighting the low participation to continuative sports programs and the high incidence to sports drop out, interesting more than 30% of adolescents. These problems are partially linked to low compliance of adolescents to coaches training, partially to the request of a sport close to adolescents requirements. However sports participation is beneficial for physical and psychological development of adolescents. Sports programs promote responsible social behaviours and greater academic success, confidence in personal physical abi…

Systemic lupus erythematosus and bullous pemphigoid with dramatic response to dapsone

2017

Patient: Female, 11 Final Diagnosis: Bullous pemphigoid in systemic lupus erythematosus Symptoms: Bullous lupus • photosensitive rash • synovitis Medication:— Clinical Procedure: Pharmacological treatment Specialty: Rheumatology Objective: Unusual clinical course Background: Bullous pemphigoid is an autoimmune blistering disease, with relapses, isolated or associated with other autoimmune diseases such as systemic lupus erythematosus (SLE). Joint manifestations rapidly respond to small or moderate doses of corticosteroids, whereas skin manifestations usually respond to antimalarial drugs. Case Report: We describe the clinical case of an 11-year-old girl with SLE. She showed bullous skin les…

Gozos al glorioso San Pedro Armengol martyr catalàn, del Real, y Militar Orden de nuestra Señora de la Merced, Redempcion de Cautivos

1750

El full orlat Grav. xil. enmarcat del sant, flanquejat per gerros amb flors Text del goig a tres col. separades per filets

Gozos al glorioso San Pedro Armengol martyr catalàn, del Real, y Militar Orden de nuestra Señora de la Merced, Redempcion de Cautivos.

El full orlat Grav. xil. enmarcat del sant, flanquejat per gerros amb flors Text del goig a tres col. separades per filets

Shikonin reduces oedema induced by phorbol ester by interfering with IκBα degradation thus inhibiting translocation of NF-κB to the nucleus

2010

Background and purpose In the present paper we studied the effect of shikonin on ear oedema induced by 12-O-tetradecanoylphorbol-13-acetate (TPA), and determined the mechanisms through which shikonin might exert its topical anti-inflammatory action. Experimental approach Acute ear oedema was induced in mice by topical application of TPA. The in vitro assays used macrophages RAW 264.7 cells stimulated with lipopolysaccharide. Cyclooxygenase-2, inducible nitric oxide synthase, protein kinase Calpha, extracellular signal-regulated protein kinase (ERK), phosphorylated ERK (pERK), c-Jun N-terminal kinase (JNK), pJNK, p38, p-p38, p65, p-p65, inhibitor protein of nuclear factor-kappaB (NF-kappaB) …

The carbon monoxide-releasing molecule CORM-2 inhibits the inflammatory response induced by cytokines in Caco-2 cells

2007

Background and purpose: Recent evidence indicates that carbon monoxide-releasing molecules (CO-RMs) exhibit potential anti-inflammatory properties. In the present study, we have investigated whether tricarbonyl dichloro ruthenium(II) dimer (CORM-2) can control the inflammatory response induced by cytokines in a human colonic epithelial cell line, Caco-2. Experimental approach: Caco-2 cells were preincubated with CORM-2 for 30 minutes and then stimulated with interleukin (IL)-1β, tumor necrosis factor-α and interferon-γ for different times. Gene expression was analyzed by real-time PCR. Protein expression was investigated by Western blot and ELISA. Transcription factor activation was determi…

Number and functionality of beta-adrenergic receptors in the mouse lymphocytic P388 leukemia as a doxorubicin-sensitive and -resistant variant.

1992

Symmetry Breaking and Establishment of Dorsal/Ventral Polarity in the Early Sea Urchin Embryo

2015

The mechanisms imposing the Dorsal/Ventral (DV) polarity of the early sea urchin embryo consist of a combination of inherited maternal information and inductive interactions among blastomeres. Old and recent studies suggest that a key molecular landmark of DV polarization is the expression of nodal on the future ventral side, in apparent contrast with other metazoan embryos, where nodal is expressed dorsally. A subtle maternally-inherited redox anisotropy, plus some maternal factors such as SoxB1, Univin, and p38-MAPK have been identified as inputs driving the spatially asymmetric transcription of nodal. However, all the mentioned factors are broadly distributed in the embryo as early as no…

Observation of the Decay X(3872)→π0χc1(1P)

2019

Using a total of 9.0 fb(-1) of e(+)e(-) collision data with center-of-mass energies between 4.15 and 4.30 GeV collected by the BESIII detector, we search for the processes e(+)e(-) gamma X(3872) with X(3872) -> pi(0)chi(cJ) for J = 0, 1, 2. We report the first observation of X(3872) -> pi(0)chi(c1), a new decay mode of the X(3872), with a statistical significance of more than 5 sigma for all systematic fit variations. Normalizing to the previously established process e(+)e(-) -> gamma X(3872) with X(3872) -> pi(+) pi(-) J/psi, we find B(X(3872) -> pi(0)chi(c1))/B(X(3872) -> pi+ pi(-) J/psi) = 0.88(-0.27)(+0.33) +/- 0.10, where the first error is statistical and the second is systematic. We …