Search results for "4-D"

showing 10 items of 955 documents

CCDC 1998476: Experimental Crystal Structure Determination

2021

Related Article: Lars J. Wesenberg, Erika Diehl, Till J. B. Zähringer, Carolin Dörr, Dieter Schollmeyer, Akihiro Shimizu, Jun‐ichi Yoshida, Ute A. Hellmich, Siegfried R. Waldvogel|2020|Chem.-Eur.J.|26|17574|doi:10.1002/chem.202003852

5-bromo-2-methoxy-N-(6-methoxy-22-dimethyl-3-oxo-34-dihydro-2H-14-benzoxazin-7-yl)benzene-1-sulfonamideSpace GroupCrystallographyCrystal SystemCrystal StructureCell ParametersExperimental 3D Coordinates
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CCDC 978372: Experimental Crystal Structure Determination

2014

Related Article: E. Bulatov, T. Chulkova, M. Haukka|2014|Acta Crystallogr.,Sect.E:Struct.Rep.Online|70|o162|doi:10.1107/S1600536814001032

5-imino-34-diphenyl-15-dihydro-2H-pyrrol-2-oneSpace GroupCrystallographyCrystal SystemCrystal StructureCell ParametersExperimental 3D Coordinates
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CCDC 1950443: Experimental Crystal Structure Determination

2021

Related Article: Liu-Pan Yang, Li Zhang, Mao Quan, Jas S. Ward, Yan-Long Ma, Hang Zhou, Kari Rissanen, Wei Jiang|2020|Nat.Commun.|11|2740|doi:10.1038/s41467-020-16534-9

613192632394552-octabutoxy-3162942-tetraazanonacyclo[46.4.0.0510.0914.01823.02227.03136.03540.04449]dopentaconta-1(52)57911131820222426313335373944464850-icosaene-2172843-tetrone 14-dinitrobenzeneSpace GroupCrystallographyCrystal SystemCrystal StructureCell ParametersExperimental 3D Coordinates
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CCDC 1993374: Experimental Crystal Structure Determination

2020

Related Article: Felix Brosge, Johannes Florian Kochs, Mariela Bregu, Khai-Nghi Truong, Kari Rissanen, Carsten Bolm|2020|Org.Lett.|22|6667|doi:10.1021/acs.orglett.0c02504

6-methyl-N-[methyl(oxo)phenylsulfanylidene]-24-dioxo-34-dihydro-2H-13-oxazine-5-carboxamideSpace GroupCrystallographyCrystal SystemCrystal StructureCell ParametersExperimental 3D Coordinates
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CCDC 844439: Experimental Crystal Structure Determination

2013

Related Article: A.Fernandez-Mato,M.D.Garcia,C.Peinador,J.M.Quintela,M.Sanchez-Andujar,B.Pato-Doldan,M.A.Senaris-Rodriguez,D.Tordera,H.J.Bolink|2013|Cryst.Growth Des.|13|460|doi:10.1021/cg301656x

7-(34-Dimethoxyphenyl)-2-ethoxy-4-phenyl-18-naphthyridine-3-carbonitrileSpace GroupCrystallographyCrystal SystemCrystal StructureCell ParametersExperimental 3D Coordinates
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Ar amīniem modificētu 1,4-dihidropiridīna atvasinājumu sintēze un īpašību pētījumi

2016

Sintezēts nekomerciāli pieejamais didodecil 2,6-bis(brometil)-4-fenil-1,4-dihidropiridīna-3,5-dikarboksilāts. Tam veikta broma aizvietošana 2,6-vietās ar dažādiem amīniem, iegūstot desmit jaunus oriģinālus savienojumus. Dots jaunsintezēto savienojumu fiziko-ķīmisko īpašību raksturojums, noteikta sintezēto savienojumu reducējošās kapacitātes aktivitāte, izmantojot fosformolibdēna kompleksa metodi, veikta antiradikālās aktivitātes noteikšana ar 1,1-difenil-2-pikrilhidrazil brīvo radikāļu metodi. Noskaidrots, ka no visiem jaunsintezētajiem savienojumiem, visaktīvākais ir didodecil 2,6-bis[(5-fluoro-2,6-diokso-3-tetrahidrofurān-2-il-pirimidīn-1-il)metil]-4-fenil-1,4-dihidropiridīna-3,5-dikarbok…

ANTIRADIKĀLĀ AKTIVITĀTE14-DIHIDROPIRIDĪNIFarmācijaAMĪNIREDUCĒJOŠĀ KAPACITĀTE
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Binding mode analysis of ABCA7 for the prediction of novel Alzheimer's disease therapeutics

2021

Graphical abstract

ATP Adenosine-triphosphateNBD nucleotide binding domainGSH reduced glutathionePolypharmacologyAlzheimer’s disease (AD)ATP-binding cassette transporterHTS high-throughput screeningBiochemistryABCA7Structural BiologyPLIF protein ligand interactionMSD membrane spanning domainPDB protein data bankTM transmembrane helixABC ATP-binding cassetteMultitarget modulation (PANABC)RMSD root mean square distanceABC transporter (ABCA1 ABCA4 ABCA7)Computer Science ApplicationsMOE Molecular Operating EnvironmentPharmacophoreSNP single-nucleotide polymorphismBiotechnologyResearch ArticleBBB blood-brain barrierBiophysicsDrug designComputational biologyBiologyAD Alzheimer’s diseasePET positron emission tomographyIC intracellular helixAPP amyloid precursor proteincryo-EM cryogenic-electron microscopyGeneticsHomology modelingBinding siteRational drug design and developmentComputingMethodologies_COMPUTERGRAPHICSNBD-cholesterol 7-nitro-2-13-benzoxadiazol-4-yl-cholesterolTransporterPSO particle swarm optimizationPET tracer (PETABC)ECD extracellular domainR-domain/region regulatory domain/regionABCA1biology.proteinEH extracellular helixTP248.13-248.65BODIPY-cholesterol 44-difluoro-4-bora-3a4a-diaza-s-indacene-cholesterolComputational and Structural Biotechnology Journal
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1,4-Dihidropiridīnu atvasinājumu nanodaļiņu toksiskuma novērtējums mikroorganismos

2017

1,4 Dihidropiridīnu (1,4 DHP) atvasinājumi ir plaša organisko vielu grupa, kurā arvien tiek sintezēti jauni savienojumi ar plašām pielietojuma iespējām. Jauno savienojumu toksicitātes raksturojums ir nepieciešams, lai paredzētu to pielietojuma iespējas un novērtētu to iedarbību uz vidi un dzīvajiem organismiem. Darbā pielāgota universāla un efektīva atšķaidījumu metode, lai noteiktu deviņu katjono amfifilo 1,4 DHP atvasinājumu toksicitātes robežkoncentrācijas sešām baktērijām un vienam raugam. Papildus noteikta 1,4 DHP atvasinājumu ietekme uz iekššūnas ATP daudzumu, skābekļa patēriņa ātrumu un etīdija bromīda transportu šūnās. Noskaidrojot toksicitātes robežkoncentrācijas un gūstot ieskatu …

ATPnanodaļiņasetīdija bromīda transportstoksicitātes novērtējumsBioloģija14-dihidropiridīna atvasinājumi
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Influence of St John's wort on catecholamine turnover and cardiovascular regulation in humans

2004

BACKGROUND: St John's wort (Hypericum perforatum) is a popular over-the-counter antidepressant. Its antidepressive effect has been attributed in part to inhibition of monoamine transporters and monoamine oxidase, on the basis of in vitro studies. METHODS: In a double-blind, randomized, placebo-controlled, crossover study, 16 healthy subjects (11 men and 5 women; mean age, 31 +/- 5 years) ingested either St John's wort (300 mg three times daily) or placebo for 7 days. Imipramine treatment (50 mg three times daily) in 7 subjects served as a positive control. After treatment, physiologic and biochemical tests included cardiovascular reflex testing, graded head-up tilt testing, and plasma catec…

AdultMaleNitroprussideImipraminemedicine.medical_specialtyPosturePharmacologyAutonomic Nervous SystemPlaceboMethoxyhydroxyphenylglycolNorepinephrine uptakeCardiovascular Physiological PhenomenaNorepinephrineCatecholaminesDouble-Blind MethodInternal medicineHeart rateSupine PositionmedicineHumansNitric Oxide DonorsPharmacology (medical)PeryleneAnthracenesPharmacologyCross-Over StudiesAdrenergic Uptake Inhibitorsbusiness.industryHemodynamicsHypericum perforatumEndocrinologyBlood pressureMonoamine neurotransmitterCatecholamine34-Dihydroxyphenylacetic AcidAntidepressantFemalebusinessHypericummedicine.drugClinical Pharmacology & Therapeutics
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Five years experience on 3,4-diaminopyridine phosphate in Lambert-Eaton syndrome: Case reports

2017

Abstract Rationale: To report our experience on 7 patients (4 males and 3 females), affected by nonparaneoplastic Lambert–Eaton myasthenic syndrome, treated with 3,4-diaminopyridine phosphate (3,4-DAPP) either alone or in combination with other immunosuppressants or steroids. Patient concerns: Patients have been evaluated at specific timepoints (ie, baseline and last 5 year follow-up), with neurological examination, autoantibodies against presynaptic voltage-gated Cav2.1 (P/Q type) calcium ion channel (VGCC) dosage, neurophysiological evaluation focusing on the increased amplitude of the compound muscle action potential (cMAP) after maximum voluntary effort, quantitative myasthenia gravis (…

AdultMalemedicine.medical_specialtyAzathioprineNeurological examination030204 cardiovascular system & hematologySeverity of Illness Index5300nonparaneoplastic-Lambert–Eaton myasthenic syndrome03 medical and health sciences0302 clinical medicinePrednisoneInternal medicineSeverity of illnessActivities of Daily LivingAzathioprinemedicineHumansMuscle StrengthClinical Case Report4-AminopyridineAdverse effect34-diaminopyridine phosphate; nonparaneoplastic-Lambert-Eaton myasthenic syndrome; 4-Aminopyridine; Activities of Daily Living; Adult; Azathioprine; Drug Therapy Combination; Female; Humans; Immunosuppressive Agents; Lambert-Eaton Myasthenic Syndrome; Male; Middle Aged; Muscle Strength; Prednisone; Severity of Illness Index; Treatment Outcome; Medicine (all)medicine.diagnostic_testbusiness.industry34-diaminopyridine phosphateGeneral MedicineMiddle Agedmedicine.diseaseMyasthenia gravisLambert-Eaton Myasthenic SyndromeTreatment OutcomeConcomitantPrednisoneDrug Therapy CombinationFemaleAmifampridinebusinessLambert-Eaton myasthenic syndrome030217 neurology & neurosurgeryImmunosuppressive Agentsmedicine.drugResearch Article
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