Search results for "405"
showing 8 items of 3208 documents
In situ formation of pyronin dyes for fluorescence protease sensing
2017
International audience; We report a reaction-based strategy for the fluorogenic detection of protease activity. Based on the "covalent-assembly" probe design principle recently put forward by the Yang group for detection of Sarin related threats (J. Am. Chem. Soc., 2014, 136, 6594-6597), we have designed two unusual nonfluorescent caged precursors (mixed bis-aryl ethers) which are readily converted into a fluorescent unsymmetrical pyronin dye through a domino cyclisation-aromatisation reaction triggered by penicillin G acylase (PGA) or leucine aminopeptidase (LAP). Fluorescence-based in vitro assays and HPLCfluorescence/- MS analyses support the claimed activation mechanism whose the furthe…
Carbonylmolybdenum complexes with di(imino)pyridine and related ligands: Reduction of a di(imino)pyridine to an aminoiminopyridine system under mild …
2006
Abstract The reactions of [Mo(CO) 6 ] towards a 2,6-di(imino)pyridine L 1 and related ligands were studied. The reaction with L 1 afforded two new complexes, [Mo(CO) 4 L 1 ] ( 1 ) and [Mo(CO) 4 L 2 ] ( 2 ), where L 2 is the 2-amino-6-iminopyridine ligand arising from the hydrogenation of one imine function of L 1 ; similar reaction with a 2-acetyl-6-iminopyridine ligand L 3 afforded [Mo(CO) 4 L 3 ] ( 3 ). Compounds 1 , 2 and 3 have been fully characterised by IR, 1 H NMR and X-ray crystallography; they present a metal ion in a pseudo-octahedral environment, the three organic ligands acting with bidentate N 2 coordination modes. One of the imine functions in 1 , the amine function in 2 , and…
Palladium(II)-Mediated Addition of Benzenediamines to Isocyanides: Generation of Three Types of Diaminocarbene Ligands Depending on the Isomeric Stru…
2016
Coupling of the palladium-bis(isocyanide) complexes cis-[PdCl2(CNR)2] (R = 2,6-Me2C6H3 1, 2-Cl-6-MeC6H3 2) with benzene-1,3-diamine (BDA1) leads to the diaminocarbene species cis-[PdCl2(CNR){C(NHR)═NH(1,3-C6H4NH2)}] (5 and 6, respectively). In this reaction, BDA1 behaves as a monofunctional nucleophile that adds to one of the RNC ligands by one amino group. By contrast, the reaction of 1 and 2 with benzene-1,4-diamine (BDA2) involves both amino functionalities of the diamine and leads to the binuclear species [cis-PdCl2(CNR){μ-C(NHR)═NH(1,4-C6H4)NH═C(NHR)}-(cis)-PdCl2(CNR)] (6 and 7) featuring two 1,4-bifunctional diaminocarbene ligands. The reaction of cis-[PdCl2(CNR)2] (R = cyclohexyl 3) …
Theoretical design of magnetic wires from acene and nanocorone derivatives
2016
Theoretical calculations on a series of molecular models based on amino derivatives of linear and cycled acenes acting as organic linkers between two copper(ii) ions have shown a wire-like magnetic behaviour, so that the intermetallic magnetic communication does not vanish when the linker becomes larger due to its polyradical nature. Hence, these models can be considered as molecular magnetic wires, which can be used as active components for molecular spintronics, where the information transport is based on spin carriers instead of the more conventional charge transport. The nature of the spin ground state along these two series of models is governed by the topology of the organic linker, i…
The Fluoro-Pauson-Khand Reaction in the Synthesis of Enantioenriched Nitrogenated Bicycles Bearing a Quaternary C-F Stereogenic Center
2019
The authors are grateful to the Spanish MICINN and the AEI (CTQ2017-84249-P) for financial support, the SCSIE (Universitat de Valencia) for access to instrumental facilities, and M. ̀ R. Pedrosa (Universidad de Burgos) for providing us with MoO2Cl2. The technical and human support provided by SGIker (UPV/EHU, MINECO, GV/DJ, ERDF, and ESF) is also gratefully acknowledged. P.B. thanks the Spanish Ministry of Economy for a Ramon y Cajal contract (RyC-2016-20951). ́ The authors are also grateful to Jose Cabeza for assistance in the synthesis of certain starting materials.
N-Alkyl Ammonium Resorcinarene Chloride Receptors for Guest Binding in Aqueous Environment
2016
Host systems with guest binding ability in water and/or biological fluids are a current challenge in supramolecular host–guest chemistry. Here we present the first syntheses of water-soluble N-ethanol ammonium resorcinarene chlorides (NARCls) with terminal hydroxyl groups at the upper rim. The NARCls possess deep cavities and are shown to bind a variety of guest molecules such as linear and cyclic alkanes, linear halogenated alkanes, and aromatic fluorophores (naphthalene, p-(phenylazo)phenol) in water through hydrophobic interactions, as well as 1,4-dioxane (a water soluble guest) via hydrogen bonds. The receptors are monomeric in aqueous media and form 1:1 host–guest complexes with bindin…
Thermal expansion and magnetic properties of benzoquinone-bridged dinuclear rare-earth complexes.
2017
The synthesis and structural characterization of two benzoquinone-bridged dinuclear rare-earth complexes [BQ(MCl2·THF3)2] (BQ = 2,5-bisoxide-1,4-benzoquinone; M = Y (1), Dy (2)) are described. Of these reported metal complexes, the dysprosium analogue 2 is the first discrete bridged dinuclear lanthanide complex in which both metal centres reside in pentagonal bipyramidal environments. Interestingly, both complexes undergo significant thermal expansion upon heating from 120 K to 293 K as illustrated by single-crystal X-ray and powder diffraction experiments. AC magnetic susceptibility measurements reveal that 2 does not show the slow relation of magnetization in zero dc field. The absent of …
Aprenentatge i ensenyament de la Geografia i la Història
2015
El document forma part dels materials docents programats mitjançant l'ajut del Servei de Política Lingüística de la Universitat de València Material per al Màster de Professorat en Eduació Secundària de Geografia i Història