Search results for "40"
showing 10 items of 17345 documents
Cell-Free Fetal DNA and Non-Invasive Prenatal Diagnosis of Chromosomopathies and Pediatric Monogenic Diseases: A Critical Appraisal and Medicolegal R…
2022
Cell-free fetal DNA (cffDNA) analysis is a non-invasive prenatal diagnostic test with a fundamental role for the screening of chromosomic or monogenic pathologies of the fetus. Its administration is performed by fetal DNA detection in the mother’s blood from the fourth week of gestation. Given the great interest regarding its validation as a diagnostic tool, the authors have set out to undertake a critical appraisal based on a wide-ranging narrative review of 45 total studies centered around such techniques. Both chromosomopathies and monogenic diseases were taken into account and systematically discussed and elucidated. Not surprisingly, cell-free fetal DNA analysis for screening purposes …
Fastlegers informasjonsbehov ved medisinsk avstandsoppfølging : En kvalitativ studie
2019
Masteroppgave helse- og sosialinformatikk HSI500 - Universitetet i Agder 2019 Bakgrunn:For å møte den fremtidige økningen i forekomsten av ikke-smittsomme kroniske sykdommerhar Norge prøvd utmedisinsk avstandsoppfølging siden2016. Resultatene så langt viser en økt trygghet, samt følelse av oppfølging og kontroll over egen helse hos pasientene. Det understrekes at det å involvere fastleger i tjenestene har vært utfordrende(Helsedirektoratet, 2018a). Videreutprøvingble startet opp i 2018 og er planlagt å fortsette til og med2021. Hensikt:Formålet med denne masteroppgaven er å bidra med kunnskap om hvordan IKT best mulig kan understøtte fastlegenes tiltenkte rolle som koordinator i medisinsk a…
Melting point, molecular symmetry and aggregation of tetrachlorobenzene isomers: the role of halogen bonding
2018
Tetrachlorobenzenes represent one of the best known, but not yet fully understood, group of isomers of the structure–melting point relationship. The differences in melting temperatures of these structurally related compounds were rationalized in terms of the hierarchy and nature of formed noncovalent interactions, and the molecular aggregation that is influenced by molecular symmetry. The highest melting point is associated with the highly symmetric 1,2,4,5-tetrachlorobenzene isomer. The structures of less symmetrical 1,2,3,4-tetrachlorobenzene and 1,2,3,5-tetrachlorobenzene, determined at 270 and 90 K, show a distinct pattern of halogen bonds, characterized by the different numbers and typ…
Pienryhmäohjaajien vertaisryhmä andragogisessa koulutuksessa
2014
Erilaisten yhteistyön muotojen, vuorovaikutuksen ja jakamisen merkitystä korostetaan tutkimuksissa, mutta opettajien ja ohjaajien kollegiaalisen tuen muotoja ei juurikaan edistetä rakenteellisin tai organisatorisin keinoin. Vertaistuki vahvistaa ohjaajien työssä kehittymistä ja jaksamista sekä koulutuksen kehittämistä.
Desempleo y crisis Económica. Los casos de España e Italia
2018
En este artículo se analiza la diferente reacción que los mercados laborales italiano y español han tenido ante la crisis económica: la tasa de paro italiana entre 2006 y 2012, ha crecido relativamente poco (pasando del 7,6 al 10,9%) mientras que la es-pañola se ha casi triplicado, pasando del 9 al 24,4%. Para ello se han analizado datos relativos a: el mercado del trabajo, la situación socioeconómica y la legislación exis-tente. Tras el estudio realizado, tres parecen ser las discrepancias más relevantes: 1) las diferencias en las tasas de actividad femenina entre ambos países; 2) la menor apertura del mercado laboral italiano en los últimos 20 años; y, 3) la diferente legis-lación sobre d…
Hyperstoichiometric interaction between silver and mercury at the nanoscale.
2012
Breaking through the stoichiometry barrier: As the diameter of silver particles is decreased below a critical size of 32?nm, the molar ratio of aqueous HgII to Ag0 drastically increases beyond the conventional Hg/Ag ratio of 0.5:1, leading to hyperstoichiometry with a maximum ratio of 1.125:1 (see figure). Therein, around 99?% of the initial silver is retained to rapidly form a solid amalgam with reduced mercury.
CD40 activity on mesenchymal cells negatively regulates OX40L to maintain bone marrow immune homeostasis under stress conditions
2021
BackgroundWithin the bone marrow (BM), mature T cells are maintained under homeostatic conditions to facilitate proper hematopoietic development. This homeostasis depends upon a peculiar elevated frequency of regulatory T cells (Tregs) and immune regulatory activities from BM-mesenchymal stem cells (BM-MSCs). In response to BM transplantation (BMT), the conditioning regimen exposes the BM to a dramatic induction of inflammatory cytokines and causes an unbalanced T-effector (Teff) and Treg ratio. This imbalance negatively impacts hematopoiesis, particularly in regard to B-cell lymphopoiesis that requires an intact cross-talk between BM-MSCs and Tregs. The mechanisms underlying the ability of…
The E3 Ubiquitin Ligase MID1 Catalyzes Ubiquitination and Cleavage of Fu
2014
Sonic Hedgehog (SHH)-GLI signalling plays an important role during embryogenesis and in tumorigenesis. The survival and growth of several types of cancer depend on autonomously activated SHH-GLI signalling. A protein complex containing the ubiquitin-ligase MID1 and protein phosphatase 2A (PP2A) regulates the nuclear localization and transcriptional activity of GLI3, a transcriptional effector molecule of SHH, in cancer cell lines with autonomously activated SHH signalling. However, the exact molecular mechanisms that mediate the interaction between MID1 and GLI3 remained unknown. Here, we show that MID1 catalyses the ubiquitination and proteasomal cleavage of the GLI3-regulator Fu. Our data…
Exploring students’ metacognition in relation to an integral-area evaluation task
2021
Several studies have been conducted to explore students’ understanding of the integral-area relationships, however, only a few focused on students’ metacognition in relation to this topic. In this study, students’ metacognitive knowledge, skills, and experiences in relation to an integral-area evaluation task are explored using semi-structured interviews and think-aloud protocol. The results show that several students developed monitoring strategies in relation to integral-area relationships; however, they do not use these strategies when solving integral-area tasks. The findings suggest that teachers and lecturers could use monitoring strategies more often when solving mathematical questio…
Longitudinal metagenomics
2018
Culture-independent approaches are revolutionizing biology. Whether in a clinical or in an environmental sample, metagenomics can reveal which microorganisms exist and what they actually do. Metagenomic studies have unveiled more microbial diversity in a few years than traditional microbiology in centuries. From the top branches down to the roots, its discoveries are reshaping the tree of life dramatically. Metagenomics is a powerful tool for the study of microbial communities, but it requires equally powerful methods of analysis. Current challenges in the analysis of metagenomic data include the accurate comparison of samples, the estimation of the uncertainty in the results, and the effec…