Search results for "41"

Secular trends in moderate-to-vigorous physical activity in 32 countries from 2002 to 2010: a cross-national perspective

2015

Background: Sufficient levels of moderate to vigorous physical activity (MVPA) give substantial health benefits to adolescents. This article examines trends in physical activity (PA) from 2002 to 2010 across 32 countries from Europe and North America. Methods: Representative samples included 479 674 pupils (49% boys) aged 11 years ( n = 156 383), 13 years ( n = 163 729) and 15 years ( n = 159 562). The trends in meeting the recommendations for PA (at least 60 min daily) were evaluated using logistic regression. Results: There was a slight overall increase between 2002 and 2010 (17.0% and 18.6%, respectively). MVPA increased significantly ( P ≤ 0.05) among boys in 16 countries. Conversely, n…

Reliability and validity of the COPE Index among caregivers of disabled people.

2017

Aim To study the reliability and validity of the Carers of Older People in Europe (COPE) Index among caregivers of disabled people of different ages. Methods A cross-sectional design of Finnish caregivers (n = 1117). Exploratory factor analysis (EFA) was performed separately on samples of three different age groups, and the internal consistencies of the subscales were investigated. Results Three factors were identified; Cronbach's alpha was 0.83–0.86 for negative impact and 0.77–0.78 for quality of support, indicating good internal consistency. The third factor, positive value, was less consistent across the age groups (α < 0.66). Conclusions The COPE Index is a valid and reliable screening…

Reliability and validity of the Finnish version of the Visual Analogue Scale Foot and Ankle (VAS-FA).

2018

Background: There have previously been no validated foot and ankle-specific patient-reported outcome measures in Finnish. Methods: The Visual Analogue Scale Foot and Ankle (VAS-FA) was translated and adapted into Finnish. Thereafter, 165 patients who had undergone foot and ankle surgery completed a questionnaire set on two separate occasions. Analyses included testing of floor-ceiling effect, internal consistency, reproducibility, and validity. Results: Minor linguistic differences emerged during the translation. Some structural adjustments were made. The mean (SD) total VAS-FA score was 74 (23). In the three subscales, maximum scores were noted in 2-5% of the responses, and internal consis…

Variability in protein binding of teicoplanin and achievement of therapeutic drug monitoring targets in critically ill patients: Lessons from the DAL…

2014

The aims of this study were to describe the variability in protein binding of teicoplanin in critically ill patients as well as the number of patients achieving therapeutic target concentrations. This report is part of the multinational pharmacokinetic DALI Study. Patients were sampled on a single day, with blood samples taken both at the midpoint and the end of the dosing interval. Total and unbound teicoplanin concentrations were assayed using validated chromatographic methods. The lower therapeutic range of teicoplanin was defined as total trough concentrations from 10 to 20 mg/L and the higher range as 10-30 mg/L. Thirteen critically ill patients were available for analysis. The followi…

Hilliness and the Development of Walking Difficulties Among Community-Dwelling Older People

2018

Objective: The objective of this study is to study the associations of objectively defined hilliness with the prevalence and incidence of walking difficulties among community-dwelling older adults, and to explore whether behavioral, health, or socioeconomic factors would fully or partially explain these associations. Method: Baseline interviews ( n = 848, 75-90 years) on difficulties in walking 500 m, frequency of moving through the neighborhood, and perceived hilliness as a barrier to outdoor mobility were conducted. Two-year follow-up interviews ( n = 551) on difficulties in walking 500 m were conducted among participants without baseline walking difficulties. Hilliness objectively defin…

Influence of Inter- and Intra-Batch Variability on the Sample Size Required for Demonstration of Equivalent Microstructure of Semisolid Dosage Forms

2020

Inter- and intra-batch variability of the quality attributes contribute to the uncertainty for demonstrating equivalent microstructure of post-approval changes and generic/hybrids of semisolid topical products. Selecting a representative sample size to describe accurately the in vitro properties of semisolids and to reach enough statistical power to demonstrate similarity between two semisolid topical products is currently challenging. The objective of this work is to establish the number of batches and units per batch to be compared based on different inter-batch and intra-batch variability to demonstrate equivalence in the physical characteristics of the products that ensure a similar mic…

Emprendimiento en personas con discapacidad. Un diagnóstico a través de la técnica de grupo nominal

2018

The aim of this work is to identify the dimensions and aspects that foster and / or restrict the entrepreneurial action of disabled people from a qualitative methodological perspective. The analysis was carried out by means of the nominal group technique. As a result of the analysis, this work proposes, through the work done with disabled people, a set of interventions that will reduce barriers and foster the entrepreneurship of such vulnerable group

Supuestos metodológicos y epistemológicos del análisis de género en cinco estudios de casos latinoamericanos

2019

Equilibrium mergers in a composite good industry with efficiencies

2014

This paper studies equilibrium merging behavior in composite good industries. Component producers face the option to either merge with a similar component producer (horizontal merger) or a complementary one (complementary merger) of a composite good. Focusing only on strategic reasons, complementary mergers arise at equilibrium only when composite goods are very differentiated while horizontal mergers otherwise. Next, when efficiencies are considered, the level of marginal cost saving required for a horizontal merger in a composite industry to result in a non- increase in the upward price pressure index (UPPI) is greater as compared with the one in a regular industry. This result can be use…

A stalactite record of four relative sea-level highstands during the Middle Pleistocene Transition

2017

International audience; Ice-sheet and sea-level fluctuations during the Early and Middle Pleistocene are as yet poorly understood. A stalactite from a karst cave in North West Sicily (Italy) provides the first evidence of four marine inundations that correspond to relative sea-level highstands at the time of the Middle Pleistocene Transition. The speleothem is located ∼97 m above mean sea level as result of Quaternary uplift. Its section reveals three marine hiatuses and a coral overgrowth that fixes the age of final marine ingression at 1.124 ± 0.2, thus making this speleothem the oldest stalactite with marine hiatuses ever studied to date. Scleractinian coral species witness light-limited…