Search results for "41"
showing 10 items of 3365 documents
One‐Pot Synthesis of Superparamagnetic CoO‐MCM‐41 Nanocomposites with Uniform and Highly Dispersed Magnetic Nanoclusters
2004
Superparamagnetic CoO-MCM-41 mesoporous nanocomposites, with variable cobalt amounts, in the form of well-dispersed CoO-like clusters, were prepared in a large compositional range by a one-step reproducible procedure employing co-hydrolysis and co-condensation of the inorganic precursors in a water/triethanolamine medium. (© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2004)
Opioid switching from and to tapentadol extended release in cancer patients: conversion ratio with other opioids
2013
Objectives: The aim of this exploratory study was to assess the conversion ratios between tapentadol and other opioids in patients requiring an opioid switching. Methods: A prospective study was carried out in a convenience sample of consecutive patients admitted to an acute palliative care unit and a home care unit for a period of 1 year. Patients who were switched from/to tapentadol were selected. The initial ratio between tapentadol and other opioids, expressed as oral morphine equivalents was 1:3.3. The subsequent doses were flexible and were changed to fit the patients’ needs. Pain intensity and distress score were recorded until opioid doses were stable. In all, 37 patients were exami…
Naringenin Nano-Delivery Systems and Their Therapeutic Applications
2021
Naringenin (NRG) is a polyphenolic phytochemical belonging to the class of flavanones and is widely distributed in citrus fruits and some other fruits such as bergamot, tomatoes, cocoa, and cherries. NRG presents several interesting pharmacological properties, such as anti-cancer, anti-oxidant, and anti-inflammatory activities. However, the therapeutic potential of NRG is hampered due to its hydrophobic nature, which leads to poor bioavailability. Here, we review a wide range of nanocarriers that have been used as delivery systems for NRG, including polymeric nanoparticles, micelles, liposomes, solid lipid nanoparticles (SLNs), nanostructured lipid carriers (NLCs), nanosuspensions, and nano…
Managing a boreal forest landscape for providing timber, storing and sequestering carbon
2015
Human well-being highly depends on ecosystem services and this dependence is expected to increase in the future with increasing population and economic growth. Studies that investigate trade-offs between ecosystem services are urgently needed for informing policy-makers. We examine the trade-offs between a provisioning (revenues from timber selling) and regulating (carbon storage and sequestration) ecosystem services among seven alternative forest management regimes in a large boreal forest production landscape. First, we estimate the potential of the landscape to produce harvest revenues and store/sequester carbon across a 50-year time period. Then, we identify conflicts between harvest re…
Eresus kollari (Araneae: Eresidae) calls for heathland management
2011
Northwest Europe’s largest heather-dominated sandy habitats are located in the nature reserve Lu¨neburgerHeide, Germany. Yet, even these appear to be losing their ability to support some of their stenotopic species such as theladybird spider, Eresus kollari Rossi 1846, and are thus becoming increasingly important for the preservation of thesespecies. The habitat requirements of this endangered spider species were investigated in order to obtain data that will helpstabilize the last remnants of the species’ population in northwest Germany. Several heathland habitats were surveyed bypitfall trapping during the mate-search period of the males. Two statistical methods were applied: logistic reg…
Protective effect of antioxidants contained in milk-based fruit beverages against sterol oxidation products
2017
Abstract Sterol oxidation products (SOPs) have shown cytotoxic effect in human intestinal cells; however, their effect within a food matrix has not been assayed yet. This study evaluated the possible cytotoxic effect of SOPs within bioaccessible fractions (BFs) of two milk-based fruit beverages with (BFA)/without (BFB) plant sterols in differentiated Caco-2 cells and if the BFs counteracted the cytotoxic effect induced by COPs mixture (30 and 60 μM). BFs did not evoke cytotoxic effect in any of the tests carried out and they protected against the loss of intestinal cohesion, mitochondrial depolarization and necrosis induced by COPs mixture. Moreover, BFB sample protected from cell cycle arr…
Zvaigžņotā Debess: 2016, Vasara (232)
2016
Contents: “ZVAIGŽŅOTĀ DEBESS” FORTY YEARS AGO: A.Balklavs. New Studies and Conclusions on Nucleus of the Galaxy (abridged) ; U.Dzērvītis. Discussion on Planetary System of Barnard’s Star Continues (abridged) ; M.Eliāss. Meeting of Solar Radio Radiation Section (abridged) ; DEVELOPMENTS in SCIENCE: O.Dumbrājs. Neutrino Oscillations: from the Outset to the Nobel Prize ; R.Misa. Conversation with Andris Ambainis on Quantum Computing Science ; DISCOVERIES: F.Gahbauer. First Direct Detection of Gravitational Waves ; I.Pundure. ATLASGAL Survey of Milky Way Completed ; SPACE RESEARCH and EXPLORATION: J.Jaunbergs. The Story of Pluto’s Satellites ; K.Schwartz. Conducting Ice and Magnetic Field of Ur…
Characterization of Nd-MCM41 obtained by impregnation
2008
Abstract Silica mesoporous molecular sieves (MCM-41), prepared by using micelles as template, were functionalized by means of incipient wetness method. Evidence for the neodymium presence in the silica matrix was obtained by means of EDX. SEM micrographs showed that impregnation does not change significantly MCM-41 morphology. The maintenance of the hexagonal structure was confirmed by XRD pattern analysis. However, the observed loss of long-range ordering, the cell parameter increase and the surface area decrease, observed by gas adsorption technique, were attributed to the introduction of neodymium oxide inside the MCM-41 mesochannels. By FT-IR and Raman spectra it was found that the main…
A Genome-Wide Screen for Interactions Reveals a New Locus on 4p15 Modifying the Effect of Waist-to-Hip Ratio on Total Cholesterol
2011
Recent genome-wide association (GWA) studies described 95 loci controlling serum lipid levels. These common variants explain ∼25% of the heritability of the phenotypes. To date, no unbiased screen for gene–environment interactions for circulating lipids has been reported. We screened for variants that modify the relationship between known epidemiological risk factors and circulating lipid levels in a meta-analysis of genome-wide association (GWA) data from 18 population-based cohorts with European ancestry (maximum N = 32,225). We collected 8 further cohorts (N = 17,102) for replication, and rs6448771 on 4p15 demonstrated genome-wide significant interaction with waist-to-hip-ratio (WHR) on …
Genetic architecture of circulating lipid levels
2011
Serum concentrations of low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), triglycerides (TGs) and total cholesterol (TC) are important heritable risk factors for cardiovascular disease. Although genome-wide association studies (GWASs) of circulating lipid levels have identified numerous loci, a substantial portion of the heritability of these traits remains unexplained. Evidence of unexplained genetic variance can be detected by combining multiple independent markers into additive genetic risk scores. Such polygenic scores, constructed using results from the ENGAGE Consortium GWAS on serum lipids, were applied to predict lipid levels in an independen…