Search results for "41"
showing 10 items of 3365 documents
“ One Ring to Bind Them All ”—Part I: The Efficiency of the Macrocyclic Scaffold for G-Quadruplex DNA Recognition
2010
International audience; Macrocyclic scaffolds are particularly attractive for designing selective G-quadruplex ligands essentially because, on one hand, they show a poor affinity for the "standard" B-DNA conformation and, on the other hand, they fit nicely with the external G-quartets of quadruplexes. Stimulated by the pioneering studies on the cationic porphyrin TMPyP4 and the natural product telomestatin, follow-up studies have developed, rapidly leading to a large diversity of macrocyclic structures with remarkable-quadruplex binding properties and biological activities. In this review we summarize the current state of the art in detailing the three main categories of quadruplex-binding …
Solution-Based Processing for Scaffold Fabrication in Tissue Engineering Applications: A Brief Review
2021
The fabrication of 3D scaffolds is under wide investigation in tissue engineering (TE) because of its incessant development of new advanced technologies and the improvement of traditional processes. Currently, scientific and clinical research focuses on scaffold characterization to restore the function of missing or damaged tissues. A key for suitable scaffold production is the guarantee of an interconnected porous structure that allows the cells to grow as in native tissue. The fabrication techniques should meet the appropriate requirements, including feasible reproducibility and time- and cost-effective assets. This is necessary for easy processability, which is associated with the large …
Robust Estimation for Discrete Markov System with Time-Varying Delay and Missing Measurements
2013
This paper addresses theℋ∞filtering problem for time-delayed Markov jump systems (MJSs) with intermittent measurements. Within network environment, missing measurements are taken into account, since the communication channel is supposed to be imperfect. A Bernoulli process is utilized to describe the phenomenon of the missing measurements. The original system is transformed into an input-output form consisting of two interconnected subsystems. Based on scaled small gain (SSG) theorem and proposed Lyapunov-Krasovskii functional (LKF), the scaled small gains of the subsystems are analyzed, respectively. New conditions for the existence of theℋ∞filters are established, and the correspondingℋ∞f…
“Anti-Bayesian” flat and hierarchical clustering using symmetric quantiloids
2017
A myriad of works has been published for achieving data clustering based on the Bayesian paradigm, where the clustering sometimes resorts to Naive-Bayes decisions. Within the domain of clustering, the Bayesian principle corresponds to assigning the unlabelled samples to the cluster whose mean (or centroid) is the closest. Recently, Oommen and his co-authors have proposed a novel, counter-intuitive and pioneering PR scheme that is radically opposed to the Bayesian principle. The rational for this paradigm, referred to as the “Anti-Bayesian” (AB) paradigm, involves classification based on the non-central quantiles of the distributions. The first-reported work to achieve clustering using the A…
Developing a Tool Point Control Scheme for a Hydraulic Crane Using Interactive Real-time Dynamic Simulation
2010
This paper describes the implementation of an interactive real-time dynamic simulation model of a hydraulic crane. The user input to the model is given continuously via joystick and output is presented continuously in a 3D animation. Using this simulation model, a tool point control scheme is developed for the specific crane, considering the saturation phenomena of the system and practical implementation. This paper describes the implementation of an interactive real-time dynamic simulation model of a hydraulic crane. The user input to the model is given continuously via joystick and output is presented continuously in a 3D animation. Using this simulation model, a tool point control scheme…
Pētera šmita vēstule latviešu un lietuviešu folkloristam, etnogrāfam Eduardam Volteram
1912
Vēstulē P. Šmits runā par latviešu mitoloģiju, tautas dziesmām, piemin A. Bīlenšteina darbu par latviešu koka celtnēm, lietuviešu valodnieku K. Būgu, kā arī interesi par citu tautu folkloru, priecātos par E. Voltera viedokli par saviem rakstiem, lūdz atsūtīt veco katoļu Katehismu.
Effects of school climate and teacher self-efficacy on job satisfaction of mostly STEM teachers: a structural multigroup invariance approach
2020
Abstract Background Identification and retention of effective teachers in STEM education play cardinal roles in teacher recruitment exercises worldwide. Studies on factors that characterize effective teachers have therefore gained popularity in recent times. Teacher self-efficacy, job satisfaction and school climate are among other factors that have attracted global attention. Thus, proper understanding of the relations between these factors is equally important. The purpose of this study is to validate and cross-validate a model of direct/indirect effects of school climate and teacher self-efficacy on job satisfaction. Results The data used for the current study are extracted from a public…
Stereoselective synthesis and transformation of pinane-based 2-amino-1,3-diols
2021
A library of pinane-based 2-amino-1,3-diols was synthesised in a stereoselective manner. Isopinocarveol prepared from (−)-α-pinene was converted into condensed oxazolidin-2-one in two steps by carbamate formation followed by a stereoselective aminohydroxylation process. The relative stereochemistry of the pinane-fused oxazolidin-2-one was determined by 2D NMR and X-ray spectroscopic techniques. The regioisomeric spiro-oxazolidin-2-one was prepared in a similar way starting from the commercially available (1R)-(−)-myrtenol (10). The reduction or alkaline hydrolysis of the oxazolidines, followed by reductive alkylation resulted in primary and secondary 2-amino-1,3-diols, which underwent a reg…
DNA traces the origin of honey by identifying plants, bacteria and fungi
2021
The regional origin of a food product commonly affects its value. To this, DNA-based identification of tissue remains could offer fine resolution. For honey, this would allow the usage of not only pollen but all plant tissue, and also that of microbes in the product, for discerning the origin. Here we examined how plant, bacterial and fungal taxa identified by DNA metabarcoding and metagenomics differentiate between honey samples from three neighbouring countries. To establish how the taxonomic contents of honey reflect the country of origin, we used joint species distribution modelling. At the lowest taxonomic level by metabarcoding, with operational taxonomic units, the country of origin …
Indefinite integrals from Wronskians and related linear second-order differential equations
2021
Many indefinite integrals are derived for Bessel functions and associated Legendre functions from particular transformations of their differential equations which are closely linked to Wronskians. A large portion of the results for Bessel functions is known, but all the results for associated Legendre functions appear to be new. The method can be applied to many other special functions. All results have been checked by differentiation using Mathematica.