Search results for "41"

Accelerometer-Based Sedentary Time, Physical Activity, and Serum Metabolome in Young Men

2022

Physical activity (PA) has been shown to associate with many health benefits but studies with metabolome-wide associations with PA are still lacking. Metabolome studies may deepen the mechanistic understanding of PA on the metabolic pathways related to health outcomes. The aim of the present study was to study the association of accelerometer based sedentary time (SB) and PA with metabolome measures. SB and PA were measured by a hip-worn accelerometer in 314 young adult men (age: mean 28, standard deviation 7 years). Metabolome was analyzed from fasting serum samples consisting of 66 metabolome measures (nuclear magnetic resonance-based metabolomics). The associations were analyzed using a …

Raising Awareness on the Clinical and Social Relevance of Adequate Chronic Pain Care.

2022

Appropriate pain care should be regarded as a right and effectively guaranteed to people with chronic pain (CP). Law 38, enacted in Italy in 2010, establishes the citizen’s right not to suffer. Twelve years later, such right appears still disregarded in Italy and the current access to adequate pain care reveals significant shortcomings. In addition, a mismatch between CP-associated burden and the available healthcare resources in the framework of our national health system has been observed. This article gathers the perspectives of a Board of Italian anesthesiologists on the state of the art of CP management in Italy and aims at strengthening the scientific rationale and clinical relevance …

Ylikuormitusta, lähijohtajan tuen puutetta vai vääränlaisia tehtäviä : miksi yhä useammat vanhustyöntekijät harkitsevat työnsä lopettamista?

2021

Yhä useampi suomalainen vanhustyöntekijä harkitsee nykyisen työnsä lopettamis-ta. Artikkelin mukaan työntekijöiden psykofyysinen kuormitus on selvästi keskeisin lopettamisaikeita ennustava tekijä. Lisäksi lopettamisaikeita ennustavat epäkohdat työn sisällössä ja lähijohtamisessa. Nuoret, yrityksissä työskentelevät, osa-aikatyötä tekevät ja yli kahden vuoden hoitotyön koulutuksen saaneet vanhustyöntekijät har-kitsivat työnsä lopettamista muita vastaajia tavallisemmin. Increasing numbers of employees working in the care of older people in Finland are seriously considering leaving their jobs. This article examines factors that predict care workers’ leaving intentions. The data consist of NORDC…

Activity-based Management in France: A focus on the information systems department of a bank

2011

International audience; The aim of the paper is to describe the Activity-based Costing and Management methods applied in France. For that purpose, we use a literature review and a case study. In a first time, we analyse the origins of the methods and their diffusion. Then we present the French situation. Finally, we propose a case study that takes place in a French bank. Our paper shows that the ABC and ABM methods are as developed in France as in the Anglo-Saxon countries and that the methods are strategically oriented.

Active caspase-3 detection to evaluate apoptosis induced by Verbena officinalis essential oil and citral in chronic lymphocytic leukaemia cells

2011

Verbena officinalis L., Verbenaceae, commonly known as vervain, is a plant widely used in medicine. Despite of its widespread use in different traditional practices, the mechanisms of pharmacological actions of the plant and its volatile oil are still unclear. We evaluated the pro-apoptotic activity of V. officinalis essential oil and of its main component, citral, on lymphocytes collected from ten patients with chronic lymphocytic leukaemia (CLL), a disease in which a faulty apoptotic mechanism is still retained one of the primary pathogenic events, by adding to treated mononuclear cells, annexin-V, propidium iodide, and CD19. Apoptosis was also evaluated using anti-active-caspase-3 monocl…

Acomiadament per causes econòmiques: causes i control judicial després de la reforma de 2012

2017

Design, Synthesis and Biological Evaluation of Novel Pyrazolo[1,2,4]triazolopyrimidine Derivatives as Potential Anticancer Agents

2021

Three novel pyrazolo-[4,3-e][1,2,4]triazolopyrimidine derivatives (1, 2, and 3) were designed, synthesized, and evaluated for their in vitro biological activity. All three compounds exhibited different levels of cytotoxicity against cervical and breast cancer cell lines. However, compound 1 showed the best antiproliferative activity against all tested tumor cell lines, including HCC1937 and HeLa cells, which express high levels of wild-type epidermal growth factor receptor (EGFR). Western blot analyses demonstrated that compound 1 inhibited the activation of EGFR, protein kinase B (Akt), and extracellular signal-regulated kinase (Erk)1/2 in breast and cervical cancer cells at concentrations…

Electrosynthesis and electrochemistry

2015

Since the pioneering work of Kolbe, electrochemistry and electrosynthetic methods have been a part of the repertoire of the organic synthesis toolbox [1–2]. In general, only electrons are employed as reagents or the reagents are electrochemically regenerated. Consequently, waste can be avoided, and limited resources can be used in a careful and economic manner. Because alternative reaction pathways are employed by electrosynthetic methods, scarce and toxic elements can be replaced or are not required at all [3]. Moreover, in the foreseeable future regenerative sources of electricity, for example, photovoltaics and wind power, will provide a surplus of electricity as the current unsteady sup…

Use of Specific Chemical Reagents for Detection of Modified Nucleotides in RNA

2011

International audience; Naturally occurring cellular RNAs contain an impressive number of chemically distinct modified residues which appear posttranscriptionally, as a result of specific action of the corresponding RNA modification enzymes. Over 100 different chemical modifications have been identified and characterized up to now. Identification of the chemical nature and exact position of these modifications is typically based on 2D-TLC analysis of nucleotide digests, on HPLC coupled with mass spectrometry, or on the use of primer extension by reverse transcriptase. However, many modified nucleotides are silent in reverse transcription, since the presence of additional chemical groups fre…

SF002-96-1, a new drimane sesquiterpene lactone from an Aspergillus species, inhibits survivin expression

2013

Survivin, a member of the IAP (inhibitor of apoptosis) gene family, is overexpressed in virtually all human cancers and is functionally involved in the inhibition of apoptosis, regulation of cell proliferation, metastasis and resistance to therapy. Because of its upregulation in malignancy, survivin has currently attracting considerable interest as a new target for anticancer therapy. In a screening of approximately 200 strains of imperfect fungi for the production of inhibitors of survivin promoter activity, a new drimane sesquiterpene lactone, SF002-96-1, was isolated from fermentations of an Aspergillus species. The compound inhibited survivin promoter activity in transiently transfected…