Search results for "41"
showing 10 items of 3365 documents
Structure of self-rated health among the oldest old: Analyses in the total population and those living with dementia
2020
No previous study has explored the structure of self-rated health (SRH), a measure holding strong predictive value for future health events, in the oldest old or in individuals with dementia. The aim was to construct a structural equation model of SRH for oldest old in general and for oldest old with dementia, and to explore direct and indirect associations between health-related factors and SRH. Cross-sectional data from the Vitality 90+, a population-based study in the city of Tampere, Finland, was used. Data were gathered by a mailed questionnaire in 2014. Altogether 1299 nonagenarians, of which 408 had self-reported dementia or cognitive decline, were included. Structural equation model…
Physical activity and exercise in mild cognitive impairment and dementia::an umbrella review of intervention and observational studies
2020
Objectives:\ud \ud The aim of this umbrella review was to determine the effect of physical activity/exercise on improving cognitive and noncognitive outcomes in people with MCI (mild cognitive impairment) and dementia.\ud \ud Design:\ud \ud Umbrella review of systematic reviews (SR), with or without meta-analyses (MAs), of randomized controlled trials (RCTs) and observational studies.\ud \ud Settings and Participants:\ud \ud People with MCI or dementia, confirmed through validated assessment measures. Any form of physical activity/exercise was included. As controls, we included participants not following any prespecified physical activity/exercise intervention or following the same standard…
Metformin Use and Cognitive Function in Older Adults With Type 2 Diabetes Following a Mediterranean Diet Intervention
2021
Background and Purpose: Both adherence to the Mediterranean diet (MedDiet) and the use of metformin could benefit the cognitive performance of individuals with type 2 diabetes, but evidence is still controversial. We examined the association between metformin use and cognition in older adults with type 2 diabetes following a MedDiet intervention. Methods: Prospective cohort study framed in the PREDIMED-Plus-Cognition sub-study. The PREDIMED-Plus clinical trial aims to compare the cardiovascular effect of two MedDiet interventions, with and without energy restriction, in individuals with overweight/obesity and metabolic syndrome. The present sub-study included 487 cognitively normal subjects…
Automatisation des tableaux de bord et cohérence du contrôle de gestion : à propos de deux cas
2007
Cet article presente les resultats d’une enquete exploratoire dont l’objet est l’etude des rapports entre l’automatisation des tableaux de bord et la coherence du controle de gestion. A partir de deux cas juges exemplaires, celui d’une entreprise industrielle et celui d’une banque, nous etudions cette relation sous l’angle du partage des representations et de la coherence des comportements. Il en ressort que l’augmentation de la formalisation ne cree pas davantage de rigidite mais produit au contraire plus de dynamique ou de continuite et de permanence. Cependant, les resultats montrent aussi la limite d’une gestion automatique de la coherence dans la mesure ou les informations necessaires …
Justifier les dépenses vestimentaires dans la recette générale de toutes les finances du duc de Bourgogne Philippe le Bon
2014
La série comptable de la recette générale de toutes les finances sous le duc de Bourgogne Philippe le Bon, remarquablement bien conservée, permet une approche fine et précise de la conjoncture vestimentaire de l’hôtel ducal, mais aussi, dans une large mesure, de l’évolution de la comptabilité. Les outils de contrôle importants, à tous les niveaux, mais aussi les changements de personnel et les réformes régulières témoignent des difficultés de l’autorité ducale à maîtriser ses finances. Le compte, outil de travail personnel, évolue en fonction de la personnalité du receveur et des contraintes auxquelles il est soumis. Ces contraintes se renforcent à l’orée des années 1440, dans un contexte g…
Representações sociais, sens pratique, poder simbólico e o processo de construção do ser docente
2019
A partir de las elaboraciones teóricas de los fundadores del campo de investigación de las representaciones sociales, se pretende avanzar en la construcción de un diálogo entre esta teoría y la praxis social de Pierre Bourdieu, centrándose en la relación entre las representaciones sociales, la praxis sensorial (como manifestación del hábito) y el poder simbólico, dimensión ausente en el modelo moscoviciano. La base empírica a partir de la cual se desarrollan las reflexiones presentes en este artículo se apoya en investigaciones realizadas sobre el proceso de construcción del ser docente, en la realidad de algunas ciudades del nordeste brasileño. En este sentido, se destaca lo que se cree qu…
Partial thioamide scan on the lipopeptaibiotic trichogin GA IV. Effects on folding and bioactivity
2012
Backbone modification is a common chemical tool to control the conformation of linear peptides and to explore potentially useful effects on their biochemical and biophysical properties. The thioamide, ψ[CS-NH], group is a nearly isosteric structural mimic of the amide (peptide) functionality. In this paper, we describe the solution synthesis, chemical characterization, preferred conformation, and membrane and biological activities of three, carefully selected, peptide analogues of the lipopeptaibiotic [Leu11-OMe] trichogin GA IV. In each analogue, a single thioamide replacement was incorporated. Sequence positions near the N-terminus, at the center, and near the C-terminus were investigated…
Safety of Dietary Guanidinoacetic Acid: A Villain of a Good Guy?
2021
Guanidinoacetic acid (GAA) is a natural amino acid derivative that is well-recognized for its central role in the biosynthesis of creatine, an essential compound involved in cellular energy metabolism. GAA (also known as glycocyamine or betacyamine) has been investigated as an energy-boosting dietary supplement in humans for more than 70 years. GAA is suggested to effectively increase low levels of tissue creatine and improve clinical features of cardiometabolic and neurological diseases, with GAA often outcompeting traditional bioenergetics agents in maintaining ATP status during stress. This perhaps happens due to a favorable delivery of GAA through specific membrane transporters (such as…
Naja, normal und normal. Zur Syntax, Semantik und Pragmatik der x-und-x-Konstruktion im Deutschen
2012
This article deals with the syntax, semantics and pragmatics of the x und x (‘x and x’) construction in German, cf. A: Schade, dass die [Schabracken] so teuer sind! B: Naja, teuer und teuer, wenn die Qualitat stimmt, dann finde ich den Preis okay. (A: ‘What a pity that the horsetrappers are so expensive!’ B: ‘Well, expensive and expensive, if the quality is good, the price is fine with me.’). The specific discourse function of this construction is to negotiate the situational meaning of a previously used lexical item. Typologically, it has been claimed that the pattern is language-specific for Scandinavian. The paper challenges this assumption, providing empirical evidence from a questionna…
Understanding Consumers’ Online Shopping Behavior during the Covid-19 Pandemic – Empirical Research
2020
The COVID-19 pandemic has impacted our daily behavior, from interactions with friends, colleagues, and family, to safety measures and working. Additionally, this pandemic has dramatically changed consumers’ shopping behavior. The purpose of this research paper is to examine the impact of Covid-19 pandemic on consumer behavior. Thus, this paper proposes a new model that incorporates three variables: attitude for online shopping during the COVID-19 pandemic, budget considerations during the COVID-19 pandemic, and future behavioral intention after the COVID-19 pandemic. This study’s main research approach is a quantitative survey and examination using a sample of Romanian consumers. Additional…