Search results for "42"

Personal Social Networks of Community-Dwelling Oldest Old During the Covid-19 Pandemic—A Qualitative Study

2021

The COVID-19 pandemic and its related restrictions have affected the everyday life of older people. Advanced age is a significant predisposing factor for a more severe COVID-19 infection, increasing the risk for hospitalization and mortality. Even though restrictions have been, thus, well-grounded, they may also have had detrimental effects on the social well-being of older people. Personal networks and social activity are known protective factors against the premature decline in health and functioning, and it is widely acknowledged that social isolation increases feelings of loneliness, poor quality of life, and even the risk for diseases and disabilities among older adults. This qualitati…

Activation of NF-kappaB and IL-8 by yersinia enterocolitica invasin protein is conferred by engagement of rac1 and MAP kinase cascades.

2003

International audience; Yersinia enterocolitica triggers activation of the nuclear factor (NF)-kappaB and production of the proinflammatory chemokine interleukin (IL)-8 in intestinal epithelial cells. This activation is due to adhesion of the bacteria via their outer membrane protein invasin to the host cells. Using Clostridium difficile toxins that specifically inactivate small GTPases, and transfection of inhibitory proteins of the Rho-GTPases, we demonstrate that Rac1, but not Cdc42 or Rho, is required for activation of NF-kappaB by invasin. Invasin activated the mitogen activated protein kinases (MAPK) p38 and c-Jun N-terminal protein kinase (JNK) but not extracellular signal regulated …

Rho GTPases in human breast tumours: expression and mutation analyses and correlation with clinical parameters

2002

In the present study, we addressed the question of a putative relevance of Rho proteins in tumour progression by analysing their expression on protein and mRNA level in breast tumours. We show that the level of RhoA, RhoB, Rac1 and Cdc42 protein is largely enhanced in all tumour samples analysed (n=15) as compared to normal tissues originating from the same individual. The same is true for 32P-ADP-ribosylation of Rho proteins which is catalysed by Clostridium botulinum exoenzyme C3. Also the amount of Rho-GDI and ERK2 as well as the level of overall 32P-GTP binding acvitity was tumour-specific elevated, yet to a lower extent than Rho proteins. Although the amount of Rho proteins was enhance…

Molecular Mechanisms of the Blockage of Glioblastoma Motility

2021

Glioblastoma (GBM) is the most common and lethal brain tumor. GBM has a remarkable degree of motility and is able to infiltrate the healthy brain. In order to perform a rationale-based drug-repositioning study, we have used known inhibitors of two small Rho GTPases, Rac1 and Cdc42, which are upregulated in GBM and are involved in the signaling processes underlying the orchestration of the cytoskeleton and cellular motility. The selected inhibitors (R-ketorolac and ML141 for Cdc42 and R-ketorolac and EHT 1864 for Rac1) have been successfully employed to reduce the infiltration propensity of GBM in live cell imaging studies. Complementarily, all-atom simulations have elucidated the molecular …

Encuentro de saberes: Huellas de memoria pluriversa y descolonización de la Universidad contemporánea

2018

This paper studies the Encounter of Knowledge as a project that, by welcoming mestres and mestras of ancestral knowledge into universities, contributes to decolonize higher education, broadening its field of memory. Based on a systematization exercise, we established a theoretical dialogue with Bajtin and Bejamin. Based on the participation of four mestres -Lucely Pío, raicera del Cerrado, Mãe Lu and Tata Mutá Imé, religious leaders of Candomblé and the political leader and shaman Álvaro Tukano of the Tukano nation- we show how the project promotes in the contemporary Brazilian university a space of mnemic pluriversity, capable of activating diverse narrative planes (biographical, political…

Current Social and Rangeland Access Trends among Pastoralists in the Western Algerian Steppe

2021

International audience; In the western Algerian steppe, the public authorities have carried out actions aimed at rural development (agricultural development programs) and combating desertification (grazing reserves) to counter the significant and rapid loss of vegetation cover of pastures by overgrazing, and the consequent impacts on local livelihoods. In the Rogassa area, these actions have impacted land tenure and the ancestral and collective way of land use and access. These changes have caused transformations in lifestyle and pasture management. This research aims to characterize how such changes are affecting local pastoralists and what their perceptions are about them. A selective sam…

Harry Francis Mallgrave. L'empatia degli spazi. Architettura e neuroscienze

2015

Le informazioni che possiamo acquisire sul molteplice aspetto della realtà passano attraverso la percezione sensoriale che il nostro corpo ha dell’esterno. La relazione fra il corpo e l’architettura è proprio il tema centrale intorno al quale si snoda il libro di Harry Francis Mallgrave che, in quanto pioniere degli studi sull'applicazione delle neuroscienze alla teoria architettonica, svela attraverso "L’empatia degli spazi" la potenza e la forza del corpo nel costruire le forme della realtà. Information we can acquire on the multiple aspect of reality passes through sensory perception that our body has of the outside. The relationship between body and architecture is the central topic of …

Enterobacter cloacae administration induces hepatic damage and subcutaneous fat accumulation in high-fat diet fed mice.

2018

Accumulating evidence indicates that gut microbiota plays a significant role in obesity, insulin resistance and associated liver disorders. Family Enterobacteriaceae and especially Enterobacter cloacae strain B29 have been previously linked to obesity and hepatic damage. The underlying mechanisms, however, remain unclear. Therefore, we comprehensively examined the effects of E. cloacae subsp. cloacae (ATCC® 13047™) administration on host metabolism of mice fed with high-fat diet (HFD). C57BL/6N mice were randomly divided into HFD control, chow control, and E. cloacae treatment groups. The E. cloacae treatment group received live bacterial cells in PBS intragastrically twice a week, every ot…

Contributo alla conoscenza della reazione di Roemer e Schilipkoeter

1974

Measurement of Physical Fitness and 24/7 Physical Activity, Standing, Sedentary Behavior, and Time in Bed in Working-Age Finns : Study Protocol for F…

2022

Background: Population studies gathering measured data on fitness and physical behavior, covering physical activity, standing, sedentary behavior, and time in bed, are scarce. This article describes the protocol of the FINFIT 2021 study that measures fitness and physical behavior in a population-based sample of adults and analyzes their associations and dose–response relationships with several health indicators. Methods: The study comprises a stratified random sample of 20–69-year-old men and women (n = 16,500) from seven city-centered regions in Finland. Physical behavior is measured 24/7 by tri-axial accelerometry and analyzed with validated MAD-APE algorithms. Health and fitness examinat…