Search results for "436"
showing 7 items of 117 documents
In vivo metabolism of LDL subfractions in patients with heterozygous FH on statin therapy
2004
LDL can be subfractionated into buoyant (1.020-1.029 g/ml(-1)), intermediate (1.030-1.040 g/ml(-1)), and dense (1.041-1.066 g/ml(-1)) LDLs. We studied the rebound of these LDL-subfractions after LDL apheresis in seven patients with heterozygous familial hypercholesterolemia (FH) regularly treated by apheresis (58 +/- 9 years, LDL-cholesterol = 342 +/- 87 mg/dl(-1), triglycerides = 109 +/- 39 mg/dl(-1)) and high-dose statins. Apolipoprotein B (apoB) concentrations were measured in LDL subfractions immediately after and on days 1, 2, 3, 5, and 7 after apheresis. Compartmental models were developed to test three hypotheses: 1) that dense LDLs are derived from the delipidation of buoyant and in…
Statins stimulate the production of a soluble form of the receptor for advanced glycation end products
2013
The beneficial effects of statin therapy in the reduction of cardiovascular pathogenesis, atherosclerosis, and diabetic complications are well known. The receptor for advanced glycation end products (RAGE) plays an important role in the progression of these diseases. In contrast, soluble forms of RAGE act as decoys for RAGE ligands and may prevent the development of RAGE-mediated disorders. Soluble forms of RAGE are either produced by alternative splicing [endogenous secretory RAGE (esRAGE)] or by proteolytic shedding mediated by metalloproteinases [shed RAGE (sRAGE)]. Therefore we analyzed whether statins influence the production of soluble RAGE. Lovastatin treatment of either mouse alveol…
In Silico Analysis of Microarray-Based Gene Expression Profiles Predicts Tumor Cell Response to Withanolides
2012
Withania somnifera (L.) Dunal (Indian ginseng, winter cherry, Solanaceae) is widely used in traditional medicine. Roots are either chewed or used to prepare beverages (aqueous decocts). The major secondary metabolites of Withania somnifera are the withanolides, which are C-28-steroidal lactone triterpenoids. Withania somnifera extracts exert chemopreventive and anticancer activities in vitro and in vivo. The aims of the present in silico study were, firstly, to investigate whether tumor cells develop cross-resistance between standard anticancer drugs and withanolides and, secondly, to elucidate the molecular determinants of sensitivity and resistance of tumor cells towards withanolides. Usi…
Plasma PAF-acetylhydrolase in patients with coronary artery disease: results of a cross-sectional analysis.
2003
Inflammation underlies both onset and perpetuation of atherosclerosis. Plasma lipoproteins transport the platelet-activating factor-acetylhydrolase (PAF-AH) with potentially anti-inflammatory activities. Our aim was to determine whether PAF-AH activity was associated with inflammatory markers and with coronary artery disease (CAD). PAF-AH activity and a panel of inflammatory mediators were measured in plasma of 496 patients with CAD and in 477 controls; 276 patients presented with stable angina pectoris and 220 with acute coronary syndrome (ACS). Individuals within the highest quartile of PAF-AH activity had an 1.8-fold increase in CAD risk [95% confidence interval (CI), 1.01 to 3.2; P = 0.…
Sobre la identidad y procedencia del poeta Filóxeno y la autoría del ditirambo ???????
2019
El presente estudio pretende resolver la controversia en torno a la identidad y procedencia del poeta Filóxeno, célebre ditirambógrafo del siglo V-IV a.C. Para ello, hemos recopilado todos los testimonios que citan a personajes con el nombre de Filóxeno desde la primera mención de Aristófanes. La investigación ha revelado que existen varios individuos con el mismo nombre y rasgos comunes. No obstante, el examen de estos testimonios revela la existencia de un único autor de ditirambos: Filóxeno de Citera. Además, creemos que este poeta fue el autor del ditirambo ???????, que algunos editores atribuyeron falsamente a Filóxeno de Léucade. Posteriormente, reflexionamos sobre la identidad de Fil…
Aristóteles entre doxografía y biografía: sobre Diógenes Laercio V 31
2019
Se pretende llamar la atención sobre un par de frases que aparecen justo hacia la mitad de la controvertida doxografía de Aristóteles que se puede leer en las Vidas y doctrinas de los filósofos más ilustres de Diógenes Laercio V 31, y que desde luego no corresponden a ningún sistema doxográfico conocido. Como sucede no pocas veces en la obra laerciana, la misma apreciación sobre si el filósofo debe o no enamorarse y contraer matrimonio se repite idéntica en otras doxografías completamente distintas: la cirenaica (DL II 91), la estoica (DL VII 129) y la epicúrea (DL X 118). Cabe plantearse, pues, el origen de este interés, en varias doxografías, por la vida sentimental, podríamos decir, de l…
A Novel Pathophysiological Mechanism Contributing to Trigeminal Neuralgia
2016
Trigeminal neuralgia (TN) is a form of neuropathic pain that affects the fifth cranial nerve, the most widely distributed nerve in the head. Although TN has been associated with a variety of pathological conditions, neurovascular compression on the trigeminal nerve, as it exits the brain stem, is the most frequent reported cause. This compression provides a progressive demyelination of the nerve and a subsequent aberrant neural transmission. Although several studies have clarified some physiopathological mechanisms underlying TN, the molecular basis remains vague. Very recently the substitution of methionine 136 by valine (MET126Val) in sodium channel Nav1.6 in a case study of typical TN ha…