Search results for "44"

Multicompartmental Lipopolyplex as Vehicle for Antigens and Genes Delivery in Vaccine Formulations

2021

Vector design and its characterization is an area of great interest in current vaccine research. In this article, we have formulated and characterized a multicompartmental lipopolyplex, which associates multiple liposomes and polyplexes in the same complex. These particles allow the simultaneous delivery of lipid or water-soluble antigens associated with genes to the same cell, in much higher amounts than conventional lipopolyplexes. The vector characterization and optimization were carried out using liposomes with entrapped carboxyfluorescein and adapted electrophoretic assays. Two types of lipopolyplexes (containing hydrophilic or lipophilic antigens) were employed to evaluate their inter…

Magnolol and Honokiol: Two Natural Compounds with Similar Chemical Structure but Different Physicochemical and Stability Properties

2021

Magnolia spp. extracts are known for their use in traditional Korean, Chinese, and Japanese medicine in the treatment of gastrointestinal disorders, anxiety, and allergies. Among their main components with pharmacological activity, the most relevant are magnolol and honokiol, which also show antitumoral activity. The objectives of this work were to study some physicochemical properties of both substances and their stability under different conditions of temperature, pH, and oxidation. Additionally, liposomes of honokiol (the least stable compound) were formulated and characterized. Both compounds showed pH-dependent solubility, with different solubility–pH profiles. Magnolol showed a lower …

Composition influence on pulmonary delivery of rifampicin liposomes.

2012

The effects of lipid concentration and composition on the physicochemical properties, aerosol performance and in vitro toxicity activity of several rifampicin-loaded liposomes were investigated. To this purpose, six liposome formulations containing different amounts of soy phosphatidylcholine and hydrogenated soy phosphatidylcholine, with and without cholesterol and oleic acid, were prepared and fully characterized. Uni- or oligo-lamellar, small (~100 nm), negatively charged (~60 mV) vesicles were obtained. Lipid composition affected aerosol delivery features of liposomal rifampicin; in particular, the highest phospholipid concentration led to a better packing of the vesic…

Exploring Bioequivalence of Dexketoprofen Trometamol Drug Products with the Gastrointestinal Simulator (GIS) and Precipitation Pathways Analyses

2019

The present work aimed to explain the differences in oral performance in fasted humans who were categorized into groups based on the three different drug product formulations of dexketoprofen trometamol (DKT) salt&mdash

On Apache Log4j2 Exploitation in Aeronautical, Maritime, and Aerospace Communication

2022

Apache Log4j2 is a prevalent logging library for Java-based applications. In December 2021, several critical and high-impact software vulnerabilities, including CVE-2021-44228, were publicly disclosed, enabling remote code execution (RCE) and denial of service (DoS) attacks. To date, these vulnerabilities are considered critical and the consequences of their disclosure far-reaching. The vulnerabilities potentially affect a wide range of internet of things (IoT) devices, embedded devices, critical infrastructure (CI), and cyber-physical systems (CPSs). In this paper, we study the effects and feasibility of exploiting these vulnerabilities in mission-critical aviation and maritime environment…

Emblemi del Novecento. Cruciverba, linguaggio, luoghi comuni: faccette di storia culturale del Moderno

2009

Taivaan tsaaritar? Valamon luostarin pääkirkon ikonostaasin Jumalanäidin ikoni

2016

Artikkelissani keskityn analysoimaan aikaisemmin Laatokalla mutta nykyisin Uudessa Valamossa Heinävedellä olevaa Jumalanäiti valtaistuimella -ikonia historiallisessa kontekstissa, jonka pääpaino on 1890–1920-luvuilla, jolloin se samoin kuin muut uuden pääkirkon (valmistui vuonna 1896) ikonostaasiin maalatut kuvat olivat uusia. Ikonien ja maallisen vallan problematiikka tiivistyy kysymykseksi, voidaanko kookkaan, vasta maalatuista ikoneista koostuvaan kuvaseinään sisältyneen teoksen tulkita ilmentäneen Romanovien hallitusta syntyaikanaan vuosisadan taitteessa ja alussa, tai sen jälkeen, kun keisarivalta päättyi ja Jumalanäiti valtaistuimella jäi Suomen tasavaltaan kuuluneeseen Karjalan osaan…

Monitieteistä tutkimusta mestari Franckesta

2018

Arvio teoksesta Ulrike Nürnberger, Elina Räsänen & Uwe Albrecht (toim.), Meister Francke Revisited: Auf den Spuren eines Hamburger Malers (Petersberg: Michael Imhof Verlag, 2017).

Microencapsulation of Enteric Bacteriophages in a pH-Responsive Solid Oral Dosage Formulation Using a Scalable Membrane Emulsification Process

2019

A scalable low-shear membrane emulsification process was used to produce microencapsulated Escherichia coli-phages in a solid oral dosage form. Uniform pH-responsive composite microparticles (mean size ~100 &micro

Collective Locomotion of Human Cells, Wound Healing and Their Control by Extracts and Isolated Compounds from Marine Invertebrates

2020

The collective migration of cells is a complex integrated process that represents a common theme joining morphogenesis, tissue regeneration, and tumor biology. It is known that a remarkable amount of secondary metabolites produced by aquatic invertebrates displays active pharmacological properties against a variety of diseases. The aim of this review is to pick up selected studies that report the extraction and identification of crude extracts or isolated compounds that exert a modulatory effect on collective cell locomotion and/or skin tissue reconstitution and recapitulate the molecular, biochemical, and/or physiological aspects, where available, which are associated to the substances und…