Exploring Bioequivalence of Dexketoprofen Trometamol Drug Products with the Gastrointestinal Simulator (GIS) and Precipitation Pathways Analyses

6533b7d0fe1ef96bd125a40d

RESEARCH PRODUCT

Exploring Bioequivalence of Dexketoprofen Trometamol Drug Products with the Gastrointestinal Simulator (GIS) and Precipitation Pathways Analyses

Gregory E. Amidon Alfredo García-arieta Naír Rodríguez-hornedo Marival Bermejo Alejandro Ruiz-picazo Yasuhiro Tsume Yasuhiro Tsume Jozef Al-gousous Jozef Al-gousous Deanna M. Mudie Bart Hens Bart Hens Gordon L. Amidon Isabel González-álvarez Gislaine Kuminek

subject

liquid–liquid phase separation SALT DISPROPORTIONATION gastrointestinal absorption Sodium lcsh:RS1-441 Pharmaceutical Science Excipient chemistry.chemical_element Salt (chemistry)Hydrochloric acid SOLUBILITY Calcium Bioequivalence Article lcsh:Pharmacy and materia medica chemistry.chemical_compound FLUIDS EMA oral absorption ABSORPTION medicine Pharmacology & Pharmacy SUPERSATURATED SOLUTIONS dexketoprofen Simulation chemistry.chemical_classification Science & Technology Chemistry liquid-liquid phase separation Phosphate Dexketoprofen SIMILARITIES gastrointestinal simulator in vitro dissolution IN-VITRO DISSOLUTION Life Sciences & Biomedicine VIVO DISSOLUTION METHODOLOGY microscopy imaging medicine.drug

description

The present work aimed to explain the differences in oral performance in fasted humans who were categorized into groups based on the three different drug product formulations of dexketoprofen trometamol (DKT) salt&mdash

year	journal	country	edition	language
2019-03-01	Pharmaceutics

https://doi.org/10.3390/pharmaceutics11030122

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