Search results for "44"

Glíptica en grafía árabe del Museo Arqueológico Nacional

2018

El trabajo presenta las doce piedras con inscripción en alfabeto árabe que se guardan en la sección de glíptica del MAN, casi todas las cuales permanecían inéditas. Incluye la descripción y medidas de cada una, lectura y traducción de su texto, y paralelos en otros centros. Comenta los estilos caligráficos y demás aspectos que las insertan en el contexto de los sellos o de las manifestaciones de piedad popular a que corresponden, según los casos. Recoge información para determinar cómo y cuándo llegaron al Museo y su posible procedencia. La conclusión es que no tienen origen andalusí, sino que se trajeron de Oriente (India, Irán o Turquía) o del Norte de África (Túnez) durante el siglo xix.…

In Vitro Evaluation of Enteric-Coated HPMC Capsules—Effect of Formulation Factors on Product Performance

2020

A comparative study on different enteric-coated hard capsules was performed. The influence of different formulation factors like choice of enteric polymer, triethyl citrate (TEC) concentration (plasticizer), talc concentrations (anti-tacking agent), and different coating process parameters on the sealing performance of the capsule and the disintegration time were investigated. Furthermore, the influence of different disintegration test methods (with disc vs. without disc and 50 mM U.S. Pharmacopoeia (USP) buffer pH 6.8 vs. biopredictive 15 mM phosphate buffer pH 6.5) was evaluated. All formulations showed sufficient but not equivalent acid resistance when tested. Polymer type was the main f…

ANALISI DESCRITTIVA DELLE PATOLOGIE ASBESTO-CORRELATE DELLA PROVINCIA DI PALERMO NEL PERIODO 2005-2009

2010

ACCERTAMENTI SANITARI PER LA VERIFICA DELL’ASSUNZIONE DI SOSTANZE STUPEFACENTI E/O PSICOTROPE IN AMBITO LAVORATIVO

2012

The Influence of the COVID‑19 Pandemic Emergency on Alcohol Use: A Focus on a Cohort of Sicilian Workers

2023

The period between the beginning and the end of the COVID-19 pandemic emergency generated a general state of stress, affecting both the mental state and physical well-being of the general population. Stress is the body’s reaction to events or stimuli perceived as potentially harmful or distressing. Particularly when prolonged over time, it can promote the consumption of different psychotropic substances such as alcohol, and thus the genesis of various pathologies. Therefore, our research aimed to evaluate the differences in alcohol consumption in a cohort of 640 video workers who carried out activities in smart working, subjects particularly exposed to stressful situations due to the string…

Cubic Microcontainers Improve In Situ Colonic Mucoadhesion and Absorption of Amoxicillin in Rats

2020

An increased interest in colonic drug delivery has led to a higher focus on the design of delivery devices targeting this part of the gastrointestinal tract. Microcontainers have previously facilitated an increase in oral bioavailability of drugs. The surface texture and shape of microcontainers have proven to influence the mucoadhesion ex vivo. In the present work, these findings were further investigated using an in situ closed-loop perfusion technique in the rat colon, which allowed for simultaneous evaluation of mucoadhesion of the microcontainers as well as drug absorption. Cylindrical, triangular and cubic microcontainers, with the same exterior surface area, were evaluated based on i…

Development and Characterization of an Amorphous Solid Dispersion of Furosemide in the Form of a Sublingual Bioadhesive Film to Enhance Bioavailabili…

2017

Administered by an oral route, Furosemide (FUR), a diuretic used in several edematous states and hypertension, presents bioavailability problems, reported as a consequence of an erratic gastrointestinal absorption due to various existing polymorphic forms and low and pH-dependent solubility. A mucoadhesive sublingual fast-dissolving FUR based film has been developed and evaluated in order to optimize the bioavailability of FUR by increasing solubility and guaranteeing a good dissolution reproducibility. The Differential Scanning Calorimetry (DSC) analyses confirmed that the film prepared using the solvent casting method entrapped FUR in the amorphous state. As a solid dispersion, FUR increa…

Optimized In Silico Modeling of Drug Absorption after Gastric Bypass: The Case of Metformin

2021

Bariatric surgery is an effective treatment for severe obesity and related comorbidities, such as type II diabetes. Gastric bypass surgery shortens the length of the intestine, possibly leading to altered drug absorption. Metformin, a first-line treatment for type II diabetes, has permeability-dependent drug absorption, which may be sensitive to intestinal anatomic changes during bypass surgery, including Roux-en-Y gastric bypass (RYGB). Previous computer simulation data indicate increased metformin absorption after RYGB. In this study, we experimentally determined the region-dependent permeability of metformin, using the rat single-pass intestinal perfusion method (SPIP), which we then imp…

Basalt Fibre Composite with Carbon Nanomodified Epoxy Matrix under Hydrothermal Ageing

2021

This work aimed to investigate the effect of hybrid carbon nanofillers (e.g., carbon nanotubes/carbon nanofibers in the ratio 1:1 by mass) over the electrical and flexural properties for an epoxy matrix and corresponding basalt fibre reinforcing composite (BFRC) subjected to full-year seasonal water absorption. Hydrothermal ageing was performed by full immersion of the tested materials into distilled water according to the following model conditions (seasons). The mechanical properties were measured in three-point bending mode before environmental ageing and after each season. Upon environmental ageing, the relative change of flexural strength and elastic modulus of the epoxy and NC was wit…

Hydrothermal Aging of an Epoxy Resin Filled with Carbon Nanofillers

2020

The effects of temperature and moisture on flexural and thermomechanical properties of neat and filled epoxy with both multiwall carbon nanotubes (CNT), carbon nanofibers (CNF), and their hybrid components were investigated. Two regimes of environmental aging were applied: Water absorption at 70 &deg