Search results for "45"

HMB-45 Immunostaining and Ultrastructure of Melanocytic Hyperplasia in Pigmented Basal Cell Carcinomas

1999

The pigmented variant of basal cell carcinoma (PBCC) may be clinically misinterpreted as malignant melanoma. Histologically this variant is characterized by the presence of functional melanocytes distributed among epithelial tumor cells, particularly in superficial areas. Our finding of a case of PBCC with numerous atypical HMB-45-positive melanocytes prompted us to analyze the morphologic and immunohistochemical features of 20 consecutive cases of PBCC. Four additional cases with numerous large HMB-45-positive melanocytes, also present in the most invasive tumor nests, were found. Ultrastructural examination was performed in two selected cases. Large melanocytes with immature (stages I an…

Dermatopatología de la oclusión intraluminal vascular: parte II (coagulopatías, émbolos y miscelánea)

2021

Resumen: La patología vascular oclusiva es causante de diversas y variadas manifestaciones clínicas, algunas de ellas con catastróficas consecuencias para el paciente. Dado que las causas de tal oclusión son muy variadas, hemos abordado en un artículo previo reciente en esta misma revista las causas trombóticas. En el presente artículo recopilamos diversas causas adicionales de oclusión intravascular. Abstract: Vascular occlusion has multiple, diverse clinical manifestations, some of which can have grave consequences for patients. It also has a wide variety of causes, including thrombi, which we recently addressed in part I of this review. In this second part, we look at additional causes o…

Clinical evaluation of melanomas and common nevi by spectral imaging

2012

A clinical trial on multi-spectral imaging of malignant and non-malignant skin pathologies comprising 17 melanomas and 65 pigmented common nevi was performed. Optical density data of skin pathologies were obtained in the spectral range 450-950 nm using the multispectral camera Nuance EX. An image parameter and maps capable of distinguishing melanoma from pigmented nevi were proposed. The diagnostic criterion is based on skin optical density differences at three fixed wavelengths: 540nm, 650nm and 950nm. The sensitivity and specificity of this method were estimated to be 94% and 89%, respectively. The proposed methodology and potential clinical applications are discussed.

M. A. CORONEL RAMOS, Juan Luis Vives. El humanista y su entorno, Institució Alfons el Magnànim, Valencia, 2017. [ISBN 978-84-7822-702-0]

2019

Esteban Estríngana, Alicia (ed.): Decidir la lealtad. Leales y desleales en contexto (siglos XVI-xVII)

2019

Association between playing tactics and creating scoring opportunities in elite football. A case study in Spanish Football National Team

2015

The aim of this study was to examine the association between playing tactics, situational variables and creating scoring opportunities according to the type of start-up possession in a case-study. All team possessions (n=857) developed by the Spanish Football national team during the World Cup 2010 were analysed and grouped into “strategic set-plays” (n=90), “recoveries” (n=451) and “restarts” (n=316). Fourteen categorical variables which describe offensive playing tactics, opponent situation as well as situational variables and their associations with creating scoring opportunities were examined using chi-square analysis and bivariate logistic regressions. Chi-square analysis showed that “…

Les cartes-marc de la Història de Valter e Griselda de Bernat Metge i les del Griseldis de Petrarca

2013

Resum: L’any 1388, Bernat Metge tradueix al catala el text llati en que Petrarca havia traslladat la darrera historia del Decamero de Boccaccio, la Historia de Valter e Griselda que el poeta d’Arezzo titula De insigni obedientia et fide uxoria . Embolcallant la seva versio de la historia, Petrarca remet sengles cartes al seu amic i autor del relat. En aquestes cartes li exposa els motius que l’han portat a traduir el text i fa consideracions sobre la conducta de Griselda. Metge tambe envolta la seva traduccio arromancada amb dues cartes i la dedica a madona Isabel de Guimera. Aquest treball es un estudi sobre l’enorme difusio que ha tingut el relat boccaccia en la historia de la literatura …

Cytochrome P450 reaction phenotyping and inhibition and induction studies of pinostrobin in human liver microsomes and hepatocytes

2017

Pinostrobin (PI, 5-hydroxy-7-methoxyflavanone) is a natural flavonoid known for its rich pharmacological activities. The objective of this study was to identify the human liver cytochrome P450 (CYP450) isoenzymes involved in the metabolism of PI. A single hydoxylated metabolite was obtained from PI after an incubation with pooled human liver microsomes (HLMs). The relative contributions of different CYP450s were evaluated using CYP450-selective inhibitors in HLMs and recombinant human CYP450 enzymes, and the results revealed the major involvement of CYP1A2, CYP2C9 and CYP2E1 in PI metabolism. We also evaluated the ability of PI to inhibit and induce human cytochrome P450 enzymes in vitro. H…

An update on metabolism studies using human hepatocytes in primary culture

2008

Background: Cultured human hepatocytes are the closest in vitro model to human liver and constitute a very predictive model for drug metabolism in vivo. The variability observed in human hepatocytes reflects the existing phenotypic heterogeneity of cytochrome P450 expression in human liver. Objectives: As drug metabolism is the major source of pharmacokinetic variability in human beings, the main areas of current drug metabolism research in human hepatocytes are reviewed. Methods: To speed up the selection of drug candidates, the evaluation of metabolic stability, metabolite profiling and identification, and drug–drug interaction potential are key issues in drug development. Results/conclus…

Genetics of the variable expression of CYP3A in humans.

2004

CYP3A isozymes participate in the metabolism of 45-60% of currently used drugs and of a variety of other compounds such as steroid hormones, toxins, and carcinogens. The CYP3A expression status is a major determinant of drug efficacy and safety, and it may also affect an individual's predisposition to certain cancers. The inter- and intraindividual expression of CYP3A is variable because of a complex interplay between genetic and environmental factors. Markers predictive of the individual CYP3A activity could improve therapies with CYP3A substrates by personalised dose adjustments, but their development has been slower than for other drug-metabolizing enzymes. Here we summarize the recent p…