6533b85efe1ef96bd12bfc51
RESEARCH PRODUCT
Clinical evaluation of melanomas and common nevi by spectral imaging
Lauma ValeineJanis KapostinshAlexey LihachevIlze DiebeleIlona KuzminaAlexander DerjaboJānis Spigulissubject
Pathologymedicine.medical_specialtyocis:(110.4234) Multispectral and hyperspectral imagingintegumentary systembusiness.industryocis:(170.4580) Optical diagnostics for medicineMelanomaMultispectral imageImage processingOptical densitymedicine.diseaseAtomic and Molecular Physics and OpticsSpectral imagingOptics in Cancer ResearchPigmented NevusMedicinesense organsRadiologybusinessClinical evaluationBiotechnologydescription
A clinical trial on multi-spectral imaging of malignant and non-malignant skin pathologies comprising 17 melanomas and 65 pigmented common nevi was performed. Optical density data of skin pathologies were obtained in the spectral range 450-950 nm using the multispectral camera Nuance EX. An image parameter and maps capable of distinguishing melanoma from pigmented nevi were proposed. The diagnostic criterion is based on skin optical density differences at three fixed wavelengths: 540nm, 650nm and 950nm. The sensitivity and specificity of this method were estimated to be 94% and 89%, respectively. The proposed methodology and potential clinical applications are discussed.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2012-02-01 | Biomedical Optics Express |