0000000000141073
AUTHOR
Ilze Diebele
Melanoma-nevus differentiation by multispectral imaging
A clinical trial on multi-spectral imaging of malignant and non-malignant skin pathologies comprising 22 melanomas and 59 pigmented nevi was performed in Latvian Oncology Center. Analysis of data obtained in the spectral range 450–950 nm using multispectral camera have led to a novel image processing algorithm capable to distinguish melanoma from pigmented nevi and different areas of activity of melanoma. The proposed methodology and potential clinical applications are discussed.
Towards noncontact skin melanoma selection by multispectral imaging analysis
A clinical trial comprising 334 pigmented and vascular lesions has been performed in three Riga clinics by means of multispectral imaging analysis. The imaging system Nuance 2.4 (CRi) and self-developed software for mapping of the main skin chromophores were used. Spe- cific features were observed and analyzed for malignant skin melanomas: notably higher absorbance (especially as the difference of optical density relative to the healthy skin), uneven chromophore distribution over the lesion area, and the possibility to select the "melanoma areas" in the correla- tion graphs of chromophores. The obtained results indicate clinical potential of this technology for noncontact selec- tion of mel…
Multi-spectral imaging analysis of pigmented and vascular skin lesions: results of a clinical trial
A clinical trial comprising 266 pigmented lesions and 49 vascular lesions has been performed in three Riga clinics by means of multi-spectral imaging analysis. The imaging system Nuance 2.4 (CRI) and self-developed software for mapping of the main skin chromophores were used. The obtained results confirm clinical potential of this technology for non-contact quantitative assessment of skin pathologies.
Contact and contactless diffuse reflectance spectroscopy: potential for recovery monitoring of vascular lesions after intense pulsed light treatment.
Optical fiber contact probe diffuse reflectance spectroscopy and remote multispectral imaging methods in the spectral range of 400 to 1100 nm were used for skin vascular malformation assessment and recovery tracing after treatment by intense pulsed light. The results confirmed that oxy-hemoglobin relative changes and the optical density difference between lesion and healthy skin in the spectral region 500 to 600 nm may be successfully used for objective appraisal of the therapy effect. Color redness parameter a* = 2 is suggested as a diagnostic border to distinguish healthy skin and vascular lesions, and as the indicator of phototreatment efficiency. Valuable diagnostic information on large…
Analysis of skin basalioma and melanoma by multispectral imaging
A clinical trial involving multi-spectral imaging of histologically confirmed 8 basaliomas and 30 melanomas was performed. Parametric maps of the melanin index, erythema index and melanoma-nevus differentiation parameter have been constructed and mutually compared. Specific features of basalioma and melanoma images were analyzed and discussed.
Clinical evaluation of melanomas and common nevi by spectral imaging
A clinical trial on multi-spectral imaging of malignant and non-malignant skin pathologies comprising 17 melanomas and 65 pigmented common nevi was performed. Optical density data of skin pathologies were obtained in the spectral range 450-950 nm using the multispectral camera Nuance EX. An image parameter and maps capable of distinguishing melanoma from pigmented nevi were proposed. The diagnostic criterion is based on skin optical density differences at three fixed wavelengths: 540nm, 650nm and 950nm. The sensitivity and specificity of this method were estimated to be 94% and 89%, respectively. The proposed methodology and potential clinical applications are discussed.
Multispectral imaging of pigmented and vascular cutaneous malformations: the influence of laser treatment
The paper investigates influence and efficacy of laser therapy on pigmented and vascular cutaneous malformations by multispectral imaging technique. Parameter mapping of skin pigmented and vascular lesions and monitoring of the laser therapy efficacy are performed by multispectral imaging in wavelength range 450-700nm by scanning step - 10nm. Parameter maps of the oxyhemoglobin deoxyhemoglobin and melanin derived from the images are presented. Possibility of laser therapy efficacy monitoring by comparison of the parameter maps before and after laser treatment has been demonstrated. As both cutaneous pigmented and vascular malformations are commonly found lesions, the parameter mapping would…