Search results for "45"
showing 10 items of 1896 documents
El obispo Vicente Roca de la Serna y su sepulcro en san Juan de la Ribera, obra del maestro marmolista Juan Bautista Semería
2016
Incorporaciones de obras de arte a las colecciones de la Real Academia de Bellas Artes de San Carlos, 2015-2016
2016
El arte de la platería en la Concatedral de San Nicolás de Alicante
2020
The Co-cathedral of San Nicolás de Alicante still preserves an important treasure of pieces of silverware, ranging from the 17th to the 20th centuries, although the greatest development was known during the 18th century, with sumptuous commissions to the most prominent silversmiths both locally as at regional and national level. In this way, it can be said that the Alicante trousseau is a good example of a temple that, once built, focuses its efforts on the collection of silverware objects that enhance the cult and its ceremonies.
Las huellas de la interdisciplinariedad en la trayectoria de Enric Mestre. ?Intercambios e investigaciones cruzadas entre las esculturas cerámicas y …
2020
La destacada actividad artística de Enric Mestre (Alboraya / Valencia, 1936) solo pude abordarse, en su compleja diversidad y riqueza, si se mantiene, como eje metodológico básico de su estudio crítico, el abierto enfoque de su sistemática interdisciplinariedad. Los diálogos e intercambios entre la escultura cerámica, la arquitectura, la pintura, el dibujo y los murales conforman precisamente el ámbito plural de su constante quehacer artístico. Especialmente la investigación se centra en las esculturas cerámicas y en las pinturas geométricas, que constituyen los dos dilatados campos de su creación plástica, cultivados asiduamente, a lo largo del último medio siglo
VV. AA. (Obra coordinada por Tito Llopis / VTiM) L' escultor Josep Ginés i Marín (1768-1823). A propòsit de "La matança dels innocents" : Catálogo de…
2020
Generation of oxysterols formed by free radicals and enzymes by electrochemical oxidation
2016
International audience; It is commonly accepted that cholesterol oxide derivatives, also named oxysterols, are 27 carbon-atom molecules deriving either from enzymatic and non-enzymatic oxidation of cholesterol. Most of these compounds can be synthesized by more or less difficult and time consuming chemical reactions, and some of them have been discovered before the identification of the enzymes [mainly cytochrome P450 enzymes (CYP enzymes)] involved in their biosynthesis. A wide range of biological activities depends on oxysterols. Some oxysterols are also involved in the synthesis of cholesterol metabolites which have various properties. The paper by Weber et al. in this issue of European …
Anti-Listeria activity of lactic acid bacteria in two traditional Sicilian cheeses
2017
<em>Listeria monocytogenes</em> is a pathogen frequently found in dairy products, and its growth is difficult to control. Bacteriocinlike inhibitory substances (BLIS), produced by lactic acid bacteria (LAB), having proven <em>in vitro</em> anti-<em>Listeria</em> activity, could provide an innovative approach to control <em>L. monocytogenes</em>; however, this application needs to be evaluated <em>in vivo</em>. In this study, twenty LAB strains isolated from different Sicilian dairy environments were tested for control of growth of <em>L. monocytogenes</em> in three different experimental trials. First, raw and UHT milk …
Nutritional strategies in an elite wheelchair marathoner at 3900 m altitude: a case report.
2019
Abstract Background Altitude training is a common practice among middle-distance and marathon runners. During acclimatization, sympathetic drive may increase resting metabolic rate (RMR), therefore implementation of targeted nutritional interventions based on training demands and environmental conditions becomes paramount. This single case study represents the first nutritional intervention performed under hypobaric hypoxic conditions (3900 m) in Paralympic sport. These results may elucidate the unique nutritional requirements of upper body endurance athletes training at altitude. Case presentation This case study examined the effects of a nutritional intervention on the body mass of a 36-y…
Cholesterol Hydroxylating Cytochrome P450 46A1: From Mechanisms of Action to Clinical Applications
2021
Cholesterol, an essential component of the brain, and its local metabolism are involved in many neurodegenerative diseases. The blood-brain barrier is impermeable to cholesterol; hence, cholesterol homeostasis in the central nervous system represents a balance betweenin situbiosynthesis and elimination. Cytochrome P450 46A1 (CYP46A1), a central nervous system-specific enzyme, converts cholesterol to 24-hydroxycholesterol, which can freely cross the blood-brain barrier and be degraded in the liver. By the dual action of initiating cholesterol efflux and activating the cholesterol synthesis pathway, CYP46A1 is the key enzyme that ensures brain cholesterol turnover. In humans and mouse models,…
Vascular biotransformation of organic nitrates is independent of cytochrome P450 monooxygenases
2020
Background and Purpose Organic nitrates such as nitroglycerin (NTG) or pentaerythritol tetranitrate (PETN) have been used for over a century in the treatment of angina or ischaemic heart disease. These compounds are prodrugs which release their nitrovasodilators upon enzymic bioactivation by aldehyde dehydrogenase (ALDH2) or cytochromes P450 (CYP). Whereas ALDH2 is known to directly activate organic nitrates in vessels, the contribution of vascular CYPs is unknown and was studied here. Experimental Approach As all CYPs depend on cytochrome P450 reductase (POR) as electron donor, we generated a smooth muscle cell-specific, inducible knockout mouse of POR (smcPOR−/−) to investigate the contri…