Search results for "45"
showing 10 items of 1896 documents
Wideband THz time domain spectroscopy based on optical rectification and electro-optic sampling
2013
We present an analytical model describing the full electromagnetic propagation in a THz time-domain spectroscopy (THz-TDS) system, from the THz pulses via Optical Rectification to the detection via Electro Optic-Sampling. While several investigations deal singularly with the many elements that constitute a THz-TDS, in our work we pay particular attention to the modelling of the time-frequency behaviour of all the stages which compose the experimental set-up. Therefore, our model considers the following main aspects: (i) pump beam focusing into the generation crystal; (ii) phase-matching inside both the generation and detection crystals; (iii) chromatic dispersion and absorption inside the c…
Induction of Human P-Glycoprotein in Caco-2 cells: Development of a Highly Sensitive Assay System for P-Glycoprotein-Mediated Drug Transport
2006
The aim of this work is to develop a highly sensitive assay system for P-gp-mediated transport by using two methods, induction of P-gp and short-term culture of Caco-2 cells. To induce P-gp in Caco-2 cells, cells were cultured in vinblastine-containing medium. The mRNA level of P-gp was approximately 7-fold higher in Caco-2 cells cultured with vinblastine (P-gp-induced Caco-2 cells) than in control cells. Western blot analysis showed a significant increase in P-gp expression. After cell differentiation, the mRNA level of P-gp was downregulated, however, P-gp-induced Caco-2 cells still possessed a 5.6-fold higher mRNA level of P-gp compared to control cells. Polarized transport of substrate …
Perron's method for the porous medium equation
2016
O. Perron introduced his celebrated method for the Dirichlet problem for harmonic functions in 1923. The method produces two solution candidates for given boundary values, an upper solution and a lower solution. A central issue is then to determine when the two solutions are actually the same function. The classical result in this direction is Wiener’s resolutivity theorem: the upper and lower solutions coincide for all continuous boundary values. We discuss the resolutivity theorem and the related notions for the porous medium equation ut −∆u = 0
Finite 2-groups with odd number of conjugacy classes
2016
In this paper we consider finite 2-groups with odd number of real conjugacy classes. On one hand we show that if $k$ is an odd natural number less than 24, then there are only finitely many finite 2-groups with exactly $k$ real conjugacy classes. On the other hand we construct infinitely many finite 2-groups with exactly 25 real conjugacy classes. Both resuls are proven using pro-$p$ techniques and, in particular, we use the Kneser classification of semi-simple $p$-adic algebraic groups.
$(BV,L^p)$-decomposition, $p=1,2$, of Functions in Metric Random Walk Spaces
2019
In this paper we study the $(BV,L^p)$-decomposition, $p=1,2$, of functions in metric random walk spaces, a general workspace that includes weighted graphs and nonlocal models used in image processing. We obtain the Euler-Lagrange equations of the corresponding variational problems and their gradient flows. In the case $p=1$ we also study the associated geometric problem and the thresholding parameters.
A Structural Theorem for Metric Space Valued Mappings of Φ-bounded Variation
2009
In this paper we introduce the notion of $\Phi$-bounded variation for metric space valued mappings defined on a subset of the real line. Such a notion generalizes the one for real functions introduced by M. Schramm, and many previous generalized variations. We prove a structural theorem for mappings of $\Phi$-bounded variation. As an application we show that each mapping of $\Phi$-bounded variation defined on a subset of $\mathbb{R}$ possesses a $\Phi$-variation preserving extension to the whole real line.
Pain assessment in Down Syndrome patients: a narrative review of the literature
2018
OBIETTIVO. Questo articolo fornisce una descrizione sintetica degli strumenti di valutazione del dolore acuto e cronico nei soggetti con sindrome di Down, indipendentemente dalla loro età e grado di deterioramento cognitivo. METODI. È stata realizzata una revisione narrativa della letteratura, ricercando tutti gli strumenti di valutazione del dolore nella popolazione con sindrome di Down, utilizzando database diversi, quali PubMed, CINAHL, Scopus, Web of Science (ISI) e Cochrane, senza limiti di tempo e pubblicati fino al mese di Ottobre 2017. Sono stati inclusi tutti gli strumenti validati applicabili ai soggetti con di sindrome di Down pubblicati sia in lingua inglese che italiana. Studi …
Emergence of Aspergillus fumigatus azole resistance in azole-naïve patients with chronic obstructive pulmonary disease and their homes.
2017
Azole-resistant Aspergillus fumigatus (ARAF) has been reported in patients with chronic obstructive pulmonary disease (COPD) but has not been specifically assessed so far. Here, we evaluated ARAF prevalence in azole-naïve COPD patients and their homes, and assessed whether CYP51A mutations were similar in clinical and environmental reservoirs. Sixty respiratory samples from 41 COPD patients with acute exacerbation and environmental samples from 36 of these patient's homes were prospectively collected. A. fumigatus was detected in respiratory samples from 11 of 41 patients (27%) and in 15 of 36 domiciles (42%). Cyp51A sequencing and selection on itraconazole medium of clinical (n = 68) and e…
Lipid-lowering drug use in Italian primary care: effects of reimbursement criteria revision
2008
OBJECTIVE: To assess whether the prescribing pattern of lipid-lowering drugs (LLD) changed after reimbursement criteria revision in a general practice in southern Italy. METHODS: From the Caserta-1 Local Health Service database, 93 general practitioners (GPs) who had consistently sent data about their patients during the years 2003-2005 were recruited. Prevalence of use and incidence of new treatments were calculated for each year, stratified by three drug cohorts: statins, omega-3 fatty acids, and fibrates. Subanalyses by gender, age, and indication of use were performed. RESULTS: Overall, 1-year prevalence of LLD use increased from 2003 to 2004. After reimbursement criteria revision (Nove…
The Influence of Single-Dose and Short-Term Administration of Quercetin on the Pharmacokinetics of Midazolam in Humans.
2015
Quercetin is a plant flavonol that is available from both daily diet and nutraceuticals. To investigate the effect of acute and short-term intake of high-dose quercetin on CYP3A-mediated metabolism, 10 healthy volunteers received 7.5 mg oral midazolam without, with a single dose of 1500 mg quercetin and after 1-week supplementation with 1500 mg quercetin daily. A substudy was performed in three subjects to explore the impact of repeated quercetin intake on intravenously administered midazolam. Coadministration with a single dose of quercetin did not significantly alter the pharmacokinetics of midazolam and its 1'-hydroxymetabolite, but following short-term quercetin intake, there was a tren…