Search results for "47"
showing 10 items of 1382 documents
Lepori, Maria: Bande, fazioni, trame. La nobiltà rurale tra violenza e giustizia nella Sardegna del Settecento
2021
Dominus qui incepit ipse perficiat: exhortaciones de fray Josep Mercader a las monjas dominicas del monasterio de Montesión en Barcelona (1740-1745)
2016
Resumen: De entre la galeria de personajes interesantes que nos ofrece el convento dominicano de Santa Catalina virgen y martir de Barcelona en el siglo XVIII destaca fray Josep Mercader (profesion 1720-1779). Un apartado importante aunque «intimo» de su obra lo constituyen las once breves exhortaciones que entre los anos 1740-1745 dirigio a las monjas dominicas del monasterio barcelones de Montesion con ocasion de las ceremonias de recepcion y profesion. En estos 20 folios podemos encontrar el discurso que un dominico cualificado dirigio a las monjas de clausura de su orden en dos momentos tan significativos de su trayectoria religiosa. Palabras clave: Josep Mercader, Dominicos (frailes y …
A gene transfer agent and a dynamic repertoire of secretion systems hold the keys to the explosive radiation of the emerging pathogen Bartonella
2013
Gene transfer agents (GTAs) randomly transfer short fragments of a bacterial genome. A novel putative GTA was recently discovered in the mouse-infecting bacterium Bartonella grahamii. Although GTAs are widespread in phylogenetically diverse bacteria, their role in evolution is largely unknown. Here, we present a comparative analysis of 16 Bartonella genomes ranging from 1.4 to 2.6 Mb in size, including six novel genomes from Bartonella isolated from a cow, two moose, two dogs, and a kangaroo. A phylogenetic tree inferred from 428 orthologous core genes indicates that the deadly human pathogen B. bacilliformis is related to the ruminant-adapted clade, rather than being the earliest diverging…
Final Results of a Phase I/II Trial of the Combination Bendamustine and Rituximab With Temsirolimus (BeRT) in Relapsed Mantle Cell Lymphoma and Folli…
2020
Abstract. In this phase I/II study, we explored the combination of Temsirolimus with Bendamustine and Rituximab (BeRT) in patients with relapsed or refractory (r/r) follicular lymphoma (FL) or mantle cell lymphoma (MCL). Patients with 1 to 3 previous therapies received Bendamustine (90 mg/m2, day 1 + 2) and Rituximab (375 mg/m2, day 1) with Temsirolimus in doses from 25 to 75 mg in phase I and 50 mg Temsirolimus in phase II, added on day 1, 8, 15 of a 28 days cycle. The primary endpoint of the phase II was ORR at the end of treatment. Overall, 39 (29 MCL, 10 FL) patients were included. Median age was 71 years and median pretreatment number was 2. Grade 3/4 non-hematologic adverse events wer…
Antonio Ballester Vilaseca, escultor. : Etapa valenciana: 1910-1940
2013
Uniqueness of diffusion on domains with rough boundaries
2016
Let $\Omega$ be a domain in $\mathbf R^d$ and $h(\varphi)=\sum^d_{k,l=1}(\partial_k\varphi, c_{kl}\partial_l\varphi)$ a quadratic form on $L_2(\Omega)$ with domain $C_c^\infty(\Omega)$ where the $c_{kl}$ are real symmetric $L_\infty(\Omega)$-functions with $C(x)=(c_{kl}(x))>0$ for almost all $x\in \Omega$. Further assume there are $a, \delta>0$ such that $a^{-1}d_\Gamma^{\delta}\,I\le C\le a\,d_\Gamma^{\delta}\,I$ for $d_\Gamma\le 1$ where $d_\Gamma$ is the Euclidean distance to the boundary $\Gamma$ of $\Omega$. We assume that $\Gamma$ is Ahlfors $s$-regular and if $s$, the Hausdorff dimension of $\Gamma$, is larger or equal to $d-1$ we also assume a mild uniformity property for $\Omega$ i…
An initial comparative map of copy number variations in the goat (Capra hircus) genome
2010
Abstract Background The goat (Capra hircus) represents one of the most important farm animal species. It is reared in all continents with an estimated world population of about 800 million of animals. Despite its importance, studies on the goat genome are still in their infancy compared to those in other farm animal species. Comparative mapping between cattle and goat showed only a few rearrangements in agreement with the similarity of chromosome banding. We carried out a cross species cattle-goat array comparative genome hybridization (aCGH) experiment in order to identify copy number variations (CNVs) in the goat genome analysing animals of different breeds (Saanen, Camosciata delle Alpi,…
7C: Computational Chromosome Conformation Capture by Correlation of ChIP-seq at CTCF motifs.
2019
Abstract Background Knowledge of the three-dimensional structure of the genome is necessary to understand how gene expression is regulated. Recent experimental techniques such as Hi-C or ChIA-PET measure long-range chromatin interactions genome-wide but are experimentally elaborate, have limited resolution and such data is only available for a limited number of cell types and tissues. Results While ChIP-seq was not designed to detect chromatin interactions, the formaldehyde treatment in the ChIP-seq protocol cross-links proteins with each other and with DNA. Consequently, also regions that are not directly bound by the targeted TF but interact with the binding site via chromatin looping are…
Transcriptomic Changes Following Partial Depletion of CENP-E in Normal Human Fibroblasts
2021
The centromere is a fundamental chromosome structure in which the macro-molecular kinetochore assembles and is bound by spindle microtubules, allowing the segregation of sister chromatids during mitosis. Any alterations in kinetochore assembly or functioning or kinetochore–microtubule attachments jeopardize chromosome stability, leading to aneuploidy, a common feature of cancer cells. The spindle assembly checkpoint (SAC) supervises this process, ensuring a faithful segregation of chromosomes. CENP-E is both a protein of the kinetochore and a crucial component of the SAC required for kinetochore–microtubule capture and stable attachment, as well as congression of chromosomes to the metaphas…
"Table 12" of "Measurement of the inclusive jet cross-section in p anti-p collisions at s**(1/2) =1.96-TeV"
1970
Correction factors for hadronization, underlying event and total non-perturbative effects for the absolute value of the jet rapidity in the range 0.4 to 0.8.