6533b823fe1ef96bd127ec77
RESEARCH PRODUCT
Transcriptomic Changes Following Partial Depletion of CENP-E in Normal Human Fibroblasts
Serena BivonaDanilo CilluffoClaudia CoronnelloAldo Di LeonardoSalvatore FeoRoberta Flavia ChiavettaFlavia ContinoViviana Barrasubject
CENP‐EKinetochoreKinetochore assemblyAneuploidyQH426-470Biologymedicine.diseasecancer progressionArticleSpindle apparatusCell biologySpindle checkpointSettore BIO/18 - Geneticaexpression profilingcentromereCentromereGeneticsmedicineSister chromatidsCENP-EaneuploidyTranscriptomeMitosisGenetics (clinical)description
The centromere is a fundamental chromosome structure in which the macro-molecular kinetochore assembles and is bound by spindle microtubules, allowing the segregation of sister chromatids during mitosis. Any alterations in kinetochore assembly or functioning or kinetochore–microtubule attachments jeopardize chromosome stability, leading to aneuploidy, a common feature of cancer cells. The spindle assembly checkpoint (SAC) supervises this process, ensuring a faithful segregation of chromosomes. CENP-E is both a protein of the kinetochore and a crucial component of the SAC required for kinetochore–microtubule capture and stable attachment, as well as congression of chromosomes to the metaphase plate. As the function of CENP-E is restricted to mitosis, its haploinsufficiency has been used to study the induced cell aneuploidy
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2021-08-26 | Genes |