Search results for "47"
showing 10 items of 1382 documents
Más allá de los oficios financieros y de justicia: patrimonialización y venalidad en la inquisición portuguesa (1536-1821)
2021
Villanos y hombres buenos. La élite campesina en el mundo rural hispano durante la época moderna
2021
Los grupos intermedios y el proceso de privatización: la difusión de los objetos indicativos de lectura y escritura en Lisboa al final del Antiguo Ré…
2021
Enrique II de Navarra en busca de bienes y rentas de Germana de Foix : relaciones diplomáticas y procesos judiciales sentenciados en Valencia (1531-1…
2021
The GTP- and Phospholipid-Binding Protein TTD14 Regulates Trafficking of the TRPL Ion Channel in Drosophila Photoreceptor Cells
2015
Recycling of signaling proteins is a common phenomenon in diverse signaling pathways. In photoreceptors of Drosophila, light absorption by rhodopsin triggers a phospholipase Cβ-mediated opening of the ion channels transient receptor potential (TRP) and TRP-like (TRPL) and generates the visual response. The signaling proteins are located in a plasma membrane compartment called rhabdomere. The major rhodopsin (Rh1) and TRP are predominantly localized in the rhabdomere in light and darkness. In contrast, TRPL translocates between the rhabdomeral plasma membrane in the dark and a storage compartment in the cell body in the light, from where it can be recycled to the plasma membrane upon subsequ…
Engineering a Circular Riboregulator in Escherichia coli
2020
RNAs of different shapes and sizes, natural or synthetic, can regulate gene expression in prokaryotes and eukaryotes. Circular RNAs have recently appeared to be more widespread than previously thought, but their role in prokaryotes remains elusive. Here, by inserting a riboregulatory sequence within a group I permuted intron-exon ribozyme, we created a small noncoding RNA that self-splices to produce a circular riboregulator in Escherichia coli . We showed that the resulting riboregulator can trans -activate gene expression by interacting with a cis -repressed messenger RNA. We characterized the system with a fluorescent reporter and with an antibiotic resistance marker, and we modeled thi…
Representation of solutions and large-time behavior for fully nonlocal diffusion equations
2017
Abstract We study the Cauchy problem for a nonlocal heat equation, which is of fractional order both in space and time. We prove four main theorems: (i) a representation formula for classical solutions, (ii) a quantitative decay rate at which the solution tends to the fundamental solution, (iii) optimal L 2 -decay of mild solutions in all dimensions, (iv) L 2 -decay of weak solutions via energy methods. The first result relies on a delicate analysis of the definition of classical solutions. After proving the representation formula we carefully analyze the integral representation to obtain the quantitative decay rates of (ii). Next we use Fourier analysis techniques to obtain the optimal dec…
Lattice operations on Rickart *-rings
2014
Various authors have investigated properties of the star order (introduced by M.P. Drazin in 1978) on algebras of matrices and of bounded linear operators on a Hilbert space. Rickart involution rings (*-rings) are a certain algebraic analogue of von Neumann algebras, which cover these particular algebras. In 1983, M.F. Janowitz proved, in particular, that, in a star-ordered Rickart *-ring, every pair of elements bounded from above has a meet and also a join. However, the latter conclusion seems to be based on some wrong assumption. We show that the conclusion is nevertheless correct, and provide equational descriptions of joins and meets for this case. We also present various general proper…
Democracia, república y federación en época isabelina. Una aproximación al proyecto federal de Roque Barcia Martí = Democracy, Republic and Federatio…
2016
Este artículo propone una aproximación al proyecto federal defendido por Roque Barcia Martí a mediados del siglo XIX, prestando especial atención a los principios teóricos y los argumentos –inspirados por una fuerte religiosidad– que sustentan su propuesta. Más allá de la estricta cuestión territorial o de las plasmaciones jurídico-políticas concretas, la federación aparece como una solución global a las tensiones de la modernidad que el Estado liberal no sabía solucionar. En este planteamiento, el campo político se configura como un espacio de humanización que reclama, como punto de partida, la necesaria reformulación política del Estado para transformar la sociedad y, potencialmente, la h…
Expression of a Truncated Yeast Ccc1 Vacuolar Transporter Increases the Accumulation of Endogenous Iron
2021
Iron is an essential micronutrient for all eukaryotic organisms because it participates as a redox cofactor in multiple metabolic processes. Iron bioavailability is highly restricted due to the low solubility of its oxidized form, frequently leading to iron deficiency anemia. The baker’s yeast Saccharomyces cerevisiae is used as a model organism for iron homeostasis studies, but also as a food supplement and fermentative microorganism in the food industry. Yeast cells use the vacuolar Ccc1 transporter to detoxify and store excess iron in the vacuoles. Here, we modulate CCC1 expression and properties to increase iron extraction from the environment. We show that constitutive expression of fu…