Search results for "48"
showing 10 items of 1388 documents
Spectroscopy of 253No and its daughters
2011
Abstract New high-statistics data have been obtained on the decay properties of 253 No and its daughters using the reaction 207 Pb( 48 Ca, 2n) 253 No. This was made possible thanks to an improved transmission of fusion–evaporation residues through the VASSILISSA recoil separator and an increased efficiency of the GABRIELA detector setup. The decay schemes of 253 No and 249 Fm have been revisited. The known level scheme of 249 Fm has been confirmed, including a new level at 669 keV excitation energy. The observation of L X-rays in coincidence with the α decay of 249 Fm gives additional support to the ground-state configuration of 1 / 2 + [ 631 ] instead of 5 / 2 + [ 622 ] for 245 Cf. In both…
Measurement of Kμ30 form factors
2007
Abstract This Letter reports on a new high precision measurement of the form factors of the K L → π ± μ ∓ ν μ decay. The data sample of about 2.3 × 10 6 events was recorded in 1999 by the NA48 experiment at CERN. Studying the Dalitz plot density we measured a linear, λ + ′ = ( 20.5 ± 2.2 stat ± 2.4 syst ) × 10 −3 , and a quadratic, λ + ″ = ( 2.6 ± 0.9 stat ± 1.0 syst ) × 10 −3 term in the power expansion of the vector form factor. No evidence was found for a second order term for the scalar form factor; the linear slope was determined to be λ 0 = ( 9.5 ± 1.1 stat ± 0.8 syst ) × 10 −3 . Using a linear fit our results were: λ + = ( 26.7 ± 0.6 stat ± 0.8 syst ) × 10 −3 and λ 0 = ( 11.7 ± 0.7 s…
Kotoutumiskoulutuksen opetussuunnitelman perusteet kuvaa tavoitettaan osallisuutta epämääräisesti ja kapeasti
2023
Kotoutumiskoulutuksen uudessa perusteasiakirjassa korostuu osallisuuden käsite. Se jää kuitenkin määrittelemättä: osallisuuteen viitataan sekä kapearajaisesti työmarkkinaosallisuutena että epäsuorasti niin, että käsitteen varsinainen merkitys jää avoimeksi. Tutkimuskirjallisuudessa osallisuus edellyttää laaja-alaista sosiaalis-yhteiskunnallista kuulumista ja yhdenvertaisuutta. nonPeerReviewed
Characterization of softwood and hardwood lignoboost kraft lignins with emphasis on their antioxidant activity
2014
Fractionation of softwood and hardwood LignoBoost kraft lignins, using sequential extraction with organic solvents of increasing hydrogen-bonding ability (dichloromethane, n-propanol, and methanol), was carried out. Using SEC, analytical pyrolysis, FTIR and UV/VIS spectroscopy, and chemical analytical methods, four fractions were obtained and characterized in terms of their yield, composition, functionality, lignin structural features, and antioxidant properties. In tests with free radicals (ABTS●+, DPPH●, O2●-) and the ORAC (oxygen radical absorbance capacity) assay, the high radical scavenging capacity of the lignin’s soluble fractions was demonstrated. The antioxidant activity of the fra…
Gatekeeper of pluripotency: A common Oct4 transcriptional network operates in mouse eggs and embryonic stem cells
2011
Abstract Background Oct4 is a key factor of an expanded transcriptional network (Oct4-TN) that governs pluripotency and self-renewal in embryonic stem cells (ESCs) and in the inner cell mass from which ESCs are derived. A pending question is whether the establishment of the Oct4-TN initiates during oogenesis or after fertilisation. To this regard, recent evidence has shown that Oct4 controls a poorly known Oct4-TN central to the acquisition of the mouse egg developmental competence. The aim of this study was to investigate the identity and extension of this maternal Oct4-TN, as much as whether its presence is circumscribed to the egg or maintained beyond fertilisation. Results By comparing …
Efficacy of combined treatment with pasireotide, pegvisomant and cabergoline in an acromegalic patient resistant to other treatments: a case report
2018
Abstract Background The approach to acromegalic patients with persistent acromegaly after surgery and inadequate response to first-generation somatostatin receptor ligands (SRLs) should be strictly tailored. Current options include new pituitary surgery and/or radiosurgery, or alternative medical treatment with SRLs high dose regimens, pegvisomant (PEG) as monotherapy, or combined therapy with the addition of PEG or cabergoline to SRLs. A new pharmacological approach includes pasireotide, a second-generation SRL approved for patients who do not adequately respond to surgery and/or for whom surgery is not an option. No reports on efficacy and safety of combined therapy with pasireotide and p…
Efficacy and safety of regorafenib for advanced gastrointestinal stromal tumours after failure of imatinib and sunitinib (GRID): an international, mu…
2013
Contains fulltext : 118365.pdf (Publisher’s version ) (Closed access) BACKGROUND: Until now, only imatinib and sunitinib have proven clinical benefit in patients with gastrointestinal stromal tumours (GIST), but almost all metastatic GIST eventually develop resistance to these agents, resulting in fatal disease progression. We aimed to assess efficacy and safety of regorafenib in patients with metastatic or unresectable GIST progressing after failure of at least imatinib and sunitinib. METHODS: We did this phase 3 trial at 57 hospitals in 17 countries. Patients with histologically confirmed, metastatic or unresectable GIST, with failure of at least previous imatinib and sunitinib were rando…
The New TNM Staging System for Thyroid Cancer and the Risk of Disease Downstaging
2018
In October 2016 the American Joint Committee on Cancer (AJCC) published the 8th edition of the AJCC/TNM cancer staging system and it has been introduced in clinical practice since 1st January 2018. The effect of most of the changes in the new edition was the downstaging of a significant number of patients into lower stages, reflecting their low risk of thyroid cancer-related death. One of the most relevant modification refers to the role of the microscopic extra-thyroidal tumor invasion, which is no longer considered as criterion for the classification of T3 tumors. With the present study we want to assess the impact of the changes of the new staging system and therefore we analyzed or casi…
Evaluation of CYP17A1 and CYP1B1 polymorphisms in male breast cancer risk
2019
Breast cancer in men is a rare and still poorly characterized disease. Inherited mutations in BRCA1, BRCA2 and PALB2 genes, as well as common polymorphisms, play a role in male breast cancer genetic predisposition. Male breast cancer is considered a hormone-dependent tumor specifically related to hyperestrogenism. Polymorphisms in genes involved in estrogen biosynthesis and metabolism pathways, such as CYP17A1 and CYP1B1, have been associated with breast cancer risk. Here, we aimed to investigate the role of CYP17A1 and CYP1B1 polymorphisms in male breast cancer risk. A series of 597 male breast cancer cases and 1022 male controls, recruited within the Italian Multicenter Study on male brea…
Identification and expression of the 11β‐steroid hydroxylase from Cochliobolus lunatus in Corynebacterium glutamicum
2019
Hydroxylation of steroids has acquired special relevance for the pharmaceutical industries. Particularly, the 11β-hydroxylation of steroids is a reaction of biotechnological importance currently carried out at industrial scale by the fungus Cochliobolus lunatus. In this work, we have identified the genes encoding the cytochrome CYP103168 and the reductase CPR64795 of C. lunatus responsible for the 11β-hydroxylase activity in this fungus, which is the key step for the preparative synthesis of cortisol in industry. A recombinant Corynebacterium glutamicum strain harbouring a plasmid expressing both genes forming a synthetic bacterial operon was able to 11β-hydroxylate several steroids as subs…