Search results for "4a"
showing 10 items of 178 documents
Cryptotanshinone deregulates unfolded protein response and eukaryotic initiation factor signaling in acute lymphoblastic leukemia cells.
2015
Abstract Background: Unfolded protein responses (UPR) determine cell fate and are recognized as anticancer targets. In a previous research, we reported that cryptotanshinone (CPT) exerted cytotoxic effects toward acute lymphoblastic leukemia cells through mitochondria-mediated apoptosis. Purpose: In the present study, we further investigated the role of UPR in CPT-induced cytotoxicity on acute lymphoblastic leukemia cells by applying tools of pharmacogenomics and bioinformatics. Methods: Gene expression profiling was performed by mRNA microarray hybridization. Potential transcription factor binding motifs were identified in the promoter regions of the deregulated genes by Cistrome software.…
CCDC 235065: Experimental Crystal Structure Determination
2005
Related Article: G.Stajer, F.Miklos, I.Kanizsai, F.Csende, R.Sillanpaa, P.Sohar|2004|Eur.J.Org.Chem.|2004|3701|doi:10.1002/ejoc.200400247
Some Applications of the Poincaré-Bendixson Theorem
2021
We consider a C 1 vector field X defined on an open subset U of the plane, with compact closure. If X has no singular points and if U is simply connected, a weak version of the Poincaré-Bendixson Theorem says that the limit sets of X in U are empty but that one can defined non empty extended limit sets contained into the boundary of U. We give an elementary proof of this result, independent of the classical Poincaré-Bendixson Theorem. A trapping triangle T based at p, for a C 1 vector field X defined on an open subset U of the plane, is a topological triangle with a corner at a point p located on the boundary ∂U and a good control of the tranversality of X along the sides. The principal app…
Integrability of orthogonal projections, and applications to Furstenberg sets
2022
Let $\mathcal{G}(d,n)$ be the Grassmannian manifold of $n$-dimensional subspaces of $\mathbb{R}^{d}$, and let $\pi_{V} \colon \mathbb{R}^{d} \to V$ be the orthogonal projection. We prove that if $\mu$ is a compactly supported Radon measure on $\mathbb{R}^{d}$ satisfying the $s$-dimensional Frostman condition $\mu(B(x,r)) \leq Cr^{s}$ for all $x \in \mathbb{R}^{d}$ and $r > 0$, then $$\int_{\mathcal{G}(d,n)} \|\pi_{V}\mu\|_{L^{p}(V)}^{p} \, d\gamma_{d,n}(V) \tfrac{1}{2}$ and $t \geq 1 + \epsilon$ for a small absolute constant $\epsilon > 0$. We also prove a higher dimensional analogue of this estimate for codimension-1 Furstenberg sets in $\mathbb{R}^{d}$. As another corollary of our method,…
Infinitely many solutions for a class of differential inclusions involving the $p$-biharmonic
2013
The existence of inffinitely many solutions for diffierential inclusions depending on two positive parameters and involving the p- biharmonic operator is established via variational methods.
CCDC 1409160: Experimental Crystal Structure Determination
2016
Related Article: Tsegaye Deyou, Ivan Gumula, Fangfang Pang, Amra Gruhonjic, Michael Mumo, John Holleran, Sandra Duffy, Paul A. Fitzpatrick, Matthias Heydenreich, Göran Landberg, Solomon Derese, Vicky Avery, Kari Rissanen, Máté Erdélyi, Abiy Yenesew|2015|J.Nat.Prod.|78|2932|doi:10.1021/acs.jnatprod.5b00581
Multiple facets of inverse continuity
2021
International audience; Inversion of various inclusions that characterize continuity in topological spaces results in numerous variants of quotient and perfect maps. In the framework of convergences, the said inclusions are no longer equivalent, and each of them characterizes continuity in a different concretely reflective subcategory of convergences. On the other hand, it turns out that the mentioned variants of quotient and perfect maps are quotient and perfect maps with respect to these subcategories. This perspective enables use of convergence-theoretic tools in quests related to quotient and perfect maps, considerably simplifying the traditional approach. Similar techniques would be un…
Group topologies coarser than the Isbell topology
2011
Abstract The Isbell, compact-open and point-open topologies on the set C ( X , R ) of continuous real-valued maps can be represented as the dual topologies with respect to some collections α ( X ) of compact families of open subsets of a topological space X . Those α ( X ) for which addition is jointly continuous at the zero function in C α ( X , R ) are characterized, and sufficient conditions for translations to be continuous are found. As a result, collections α ( X ) for which C α ( X , R ) is a topological vector space are defined canonically. The Isbell topology coincides with this vector space topology if and only if X is infraconsonant. Examples based on measure theoretic methods, t…
Variations of selective separability II: Discrete sets and the influence of convergence and maximality
2012
A space $X$ is called selectively separable(R-separable) if for every sequence of dense subspaces $(D_n : n\in\omega)$ one can pick finite (respectively, one-point) subsets $F_n\subset D_n$ such that $\bigcup_{n\in\omega}F_n$ is dense in $X$. These properties are much stronger than separability, but are equivalent to it in the presence of certain convergence properties. For example, we show that every Hausdorff separable radial space is R-separable and note that neither separable sequential nor separable Whyburn spaces have to be selectively separable. A space is called \emph{d-separable} if it has a dense $\sigma$-discrete subspace. We call a space $X$ D-separable if for every sequence of …
CCDC 749971: Experimental Crystal Structure Determination
2010
Related Article: Y.Rousselin, N.Sok, F.Boschetti, R.Guilard, F.Denat|2010|Eur.J.Org.Chem.|2010|1688|doi:10.1002/ejoc.200901183