Search results for "52"

ALS-RELATED FUS PROTEIN IS MISLOCALIZED TO CYTOPLASM AND RECRUITED INTO STRESS GRANULES IN FIBROBLASTS OF ASYMPTOMATIC FUS P525L MUTATION CARRIERS

Symptoms onset in Amyotrophic Lateral Sclerosis (ALS) occur when over 70% of motor neurons is already lost, suggesting a relatively long pre-symptomatic phase. The description of several genes linked to ALS (e.g., SOD1, FUS, TARDP, C9orf72) has now allowed identification of pre-symptomatic carriers. These pre-symptomatic (or even preclinical) carriers can be followed up with the aim to identify the very early clinical disease-related changes or a valuable biomarker. These efforts seem at present the best approach for the implementation of an early symptomatic therapy or for the disease prevention. In this work, we studied the expression of FUS protein in cultured skin fibroblasts from pre-s…

Genetic Factors as Promising Biomarkers of Sporadic Ascending Aortic Aneurysm

2014

Thoracic aorta shows various changes with advancing age and a progressive deterioration in structure and function. As a result, vascular remodeling (VR) and medial degeneration (MD) occur. VR and MD are typical entities of sporadic thoracic aortic aneurysm (TAA), actually considered a common and serious health risk and a pathology by unclear mechanisms. Increased activity of the coagulation system, inflammation, activation of extracellular matrix remodeling and endothelial dysfunction pathways have been recently evidenced to have a key role in its onset. Thus, polymorphisms of the coagulation system [fibrinogen (rs1800790); Factor II ( rs1799963); Factor V (rs6025); Factor VII (rs121964926)…

Are they different? affect, feeling, emotion, sentiment, and opinion detection in text

2014

A major limitation in the automatic detection of affect, feelings, emotions, sentiments, and opinions in text is the lack of proper differentiation between these subjective terms and understanding of how they relate to one another. This lack of differentiation not only leads to inconsistency in terminology usage but also makes the subtleties and nuances expressed by the five terms difficult to understand, resulting in subpar detection of the terms in text. In light of such limitation, this paper clarifies the differences between these five subjective terms and reveals significant concepts to the computational linguistics community for their effective detection and processing in text.

Social support in the workplace for physicians in specialization training

2018

ABSTRACT When becoming a specialist, learning-through-service plays a significant role. The workplace affords good opportunities for learning, but the service-learning period may also impose stress on phycisians in specialization training. In medical work, social support has proved to be a very important factor in managing stress. Social support may afford advantages also for learning and professional identity building. However, little was known about how social support is perceived by doctors in specialization training. This study aimed to understand the perceptions of physicians in specialization training regarding social support communication in their workplace during their learning-thro…

Cultural Politics of Love and Provision among Poor Youth in Urban Tanzania

2015

This article examines how urban youth in the poorest neighbourhoods of Dar es Salaam negotiate the terms of transactional intimacy, that is, heterosexual relations in which men are expected to provide for women materially. Using the concept of ‘affect’, I argue that this negotiation involves different levels of male providership, as well as moral values attached to notions of ‘true love’ and the Swahili concept of tamaa. Poor men and women view their agency differently within transactional intimacy, with women describing themselves as exploited by men who do not fulfil their end of the transactional bargain, and poor men portraying themselves as deeply disempowered in comparison to wealthie…

Three Halves of a Whole : Redefining East and West in UNESCO’s East-West Major Project 1957-1966

2017


 
 
 In 1946 Julian Huxley, UNESCO’s rst Director-General, suggested that two opposing philosophies of life were confronting each other from the East and the West, setting the focus on the cultural aspect of this polarisation and de ning the possibility of an East- West conflict as the main threat to world peace. A decade later, in 1957, UNESCO launched The Major Project on the Mutual Appreciation of Eastern and Western Cultural Values to promote its ideas of intercultural understanding as a means to maintaining peace. The core concepts of the Project, East and West, were not strictly defined. Here East and West, as concepts, fit Reinhart Koselleck’s definition of Grundbegri…

Dynamic Sustainability. Sustainability Window Analysis of Chinese Poverty-Environment Nexus Development

2015

Sustainability Window is a new analysis tool for assessing the sustainability of development simultaneously in all of its three dimensions (environmental, economic, and social). The analysis method provides information of the maximum and minimum economic development that is required to maintain the direction of social and environmental development towards more sustainable targets. With the Sustainability Window method it is possible to easily analyze the sustainability using different indicators and different time periods making comparative analyses easy. The new method makes it also possible to analyze the dynamics of the sustainability and the changes over time in the width of the window.…

Exercising exclusions: Space, visibility, and monitoring of the exercising fat female body

2019

The author’s aim is to inspect the position of the fat (female) body in the field of exercise. Specifically, the author is interested in fat women’s experiences of their treatment while exercising in public, and argues that, in particular, public spaces for exercise, such as gyms and swimming pools, are currently discursively and concretely constructed as “exclusive” spaces for the normative bodied. Bodies that are deemed non-normative, such as fat bodies, are often made either invisible or intolerable in the discourse of physical activity and exercise. Consequently, public spaces for exercise such as gyms or swimming pools are seen as out of bounds for non-normative bodies and this is refl…

Memorializing mass deaths at the border: two cases from Canberra (Australia) and Lampedusa (Italy)

2017

In this paper, we compare two seemingly very similar instances in which individuals and organizations within the borders of the global North have memorialized the deaths of irregular migrants at sea: the SIEV X memorial in Australia’s national capital Canberra, and the Giardino della memoria (Garden of Remembrance) on the Italian island of Lampedusa. Unlike ephemeral manifestations of grief, potentially these memorials have effects that reach well beyond their creation. We relate the differences between the memorials to the contexts within which they were created: an immediate local response involving people directly affected by the disaster’s aftermath, on the one hand, and a delayed natio…

De-demonising Japan? Transitioning from war to peace through Japan’s cinematic post-war cultural diplomacy in UNESCO’sOrientproject 1957–1959

2017

AbstractIn 1959, UNESCO published a film catalogue titled Orient. A Survey of Films Produced in Countries of Arab and Asian Culture to familiarise Western audiences with Eastern cultures. Out of the 139 feature films included in the catalogue, 37 were Japanese. Through a discussion of the descriptions of the films provided in the catalogue, this article analyses Japan’s post-war cultural diplomacy in the context of the Orient project. The aim is to discuss the question of what purpose the Japanese films chosen for the Orient catalogue served in terms of cultural diplomacy. The analysis suggests the Japanese representatives aimed to position the nation in the international arena outside the …