Search results for "53"
showing 10 items of 2908 documents
Generating p53-specific cytotoxic T lymphocytes by recombinant adenoviral vector-based vaccination in mice, but not man.
2002
Mutations and aberrant expression of the p53 tumor suppressor protein are the most frequent molecular alterations in human malignancy. Peptides derived from the wild-type (wt) p53 protein and presented by major histocompatibility complex (MHC) molecules for T lymphocyte recognition are believed to serve as universal tumor-associated antigens for cancer immunotherapy. We studied the immunogeneicity of a recombinant replication-defective adenoviral vector encoding human full-length wt p53 (rAd/hup53) in human leukocyte antigen (HLA)-A2K(b)-transgenic (Tg) mice and man. The generation of p53 epitope-specific cytotoxic T lymphocytes (CTLs) in p53-proficient and p53-deficient A2K(b)-Tg mice was …
Les vicissituds de la traducció al castellà d’elements heroics i medievals del Canigó, de Jacint Verdaguer. El cas de «La Maladeta»
2014
Resum: En aquest article s’estudien les dificultats de traduir «La Maladeta», un passatge de Canigó, de Jacint Verdaguer. Creiem que aquest fragment és prou representatiu de la temàtica del poema èpic verdaguerià, ja que ha estat un dels més traduïts a totes les llengües i, a més, conté elements heroics i medievals del poema. És per això que hem cregut oportú de fer l’anlàlisi de la traducció dels fragments, per poder treure’n unes conclusions que ens serveixin per avaluar la qualitat de cada versió.Paraules clau: Verdaguer, Canigó, medieval, traducció. Abstract: In this article we study the translation’s difficulties of «La Maladeta», an extract of Canigó by Jacint Verdaguer. We think that…
Josefa Verride y Martina de los Ángeles. El difícil camino hacia la santidad.
2016
Resumen: A través de la información que nos proporcionan las vidas de Josefa Verride, tercera de la orden dominica en Huesca y Martina de los Ángeles, religiosa de la misma orden, fundadora del convento de san Pedro de Benabarre, pretendo aportar nuevas ideas acerca del proceso de adquisición de la fama de santidad de algunas mujeres en la Edad Moderna española. Las órdenes religiosas debieron idear estrategias que ayudasen a legitimar y consolidar la fama de santidad de estas mujeres. Una de estas estrategias fue la vinculación de las religiosas con otras mujeres con fama de santidad, creando genealogías femeninas que les permitiesen perpetuar su memoria y prestigio a lo largo del tiempo. …
Autobiografía y memoria en el diario de viajes del VI Conde de Fernán Núñez = Autobiography and Memory in the Travel Diary of the VI Count of Fernán …
2016
ResumenEl viaje fue una constante en la vida de don Carlos José Gutiérrez de los Ríos, VI conde de Fernán Núñez (1742-1795). A través de ellos pudo cumplir con su servicio al rey y con sus responsabilidades como cabeza del linaje. Asimismo pudo completar su formación y satisfacer anhelos más personales. De todos sus viajes, los realizados dentro y fuera de España, guardó memoria escrita en un diario de viajes, un documento que, en formato manuscrito, se conservó en su archivo familiar. En un periodo cronológico en el que el viaje y su relato adquirieron especial protagonismo, este trabajo analiza el papel que el viaje jugó en la vida y memoria del VI conde de Fernán Núñez y su impronta dent…
On one-dimensionality of metric measure spaces
2019
In this paper, we prove that a metric measure space which has at least one open set isometric to an interval, and for which the (possibly non-unique) optimal transport map exists from any absolutely continuous measure to an arbitrary measure, is a one-dimensional manifold (possibly with boundary). As an immediate corollary we obtain that if a metric measure space is a very strict $CD(K,N)$ -space or an essentially non-branching $MCP(K,N)$-space with some open set isometric to an interval, then it is a one-dimensional manifold. We also obtain the same conclusion for a metric measure space which has a point in which the Gromov-Hausdorff tangent is unique and isometric to the real line, and fo…
A p53-Dependent Tumor Suppressor Network Is Induced by Selective miR-125a-5p Inhibition in Multiple Myeloma Cells
2014
The analysis of deregulated microRNAs (miRNAs) is emerging as a novel approach to disclose the regulation of tumor suppressor or tumor promoting pathways in tumor cells. Targeting aberrantly expressed miRNAs is therefore a promising strategy for cancer treatment. By miRNA profiling of primary plasma cells from multiple myeloma (MM) patients, we previously reported increased miR-125a-5p levels associated to specific molecular subgroups. On these premises, we aimed at investigating the biological effects triggered by miR-125a-5p modulation in MM cells. Expression of p53 pathway-related genes was down-regulated in MM cells transfected with miR-125a-5p mimics. Luciferase reporter assays confirm…
Formation of microbial organic carbonates during the Late Jurassic from the Northern Tethys (Amu Darya Basin, Uzbekistan): implications for Jurassic …
2020
23 pages; International audience; The Late Jurassic was a period of major global carbon cycle perturbations with episodes of anoxia leading to regional accumulation of organic matter in sediments worldwide. The Tubiegatan section (SW Gissar Mountains, Uzbekistan) located in the Northern Tethys, shows atypical organic-rich limestone and marl deposits (up to 6% of total organic carbon) marked by pronounced negative excursions of δ13Ccarb (amplitude of ca. 12‰) and δ13Corg (amplitude of ca. 4‰) recorded during the Middle Oxfordian (Transversarium Zone). A transdisciplinary approach including sedimentology, palynofacies characterization, mineralogy, organic and inorganic geochemistry was carrie…
Curs d'Econometria: part teòrica
2015
El document conté les transparències usades per il·lustrar i complementar les classes teòriques de l'assignatura Econometria, codi 35.820, que s'imparteix en el Grau d'Administració i Direcció d'Empreses de la Universitat de València. És un curs d'introducció a l'Econometria amb sis unitats temàtiques: 1) Models economètrics i dades econòmiques 2) El model de regressió 3) Propietats i hipòtesis en el model de regressió 4) Contrastament de hipòtesis en el model de regressió múltiple 5) Anàlisi de regressió múltiple amb informació qualitativa 6) Incompliment de les hipòtesis bàsiques
CNO and pep solar neutrino measurements and perspectives in Borexino
2015
International audience; The detection of neutrinos emitted in the CNO reactions in the Sun is one of the ambitious goals of Borexino Phase-II. A measurement of CNO neutrinos would be a milestone in astrophysics, and would allow to solve serious issues in current solar models. A precise measurement of the rate of neutrinos from the pep reaction would allow to investigate neutrino oscillations in the MSW transition region. The pep and CNO solar neutrino physics, the measurement in Borexino Phase-I and the perspectives for the new phase are reviewed in this proceeding.
Measurement of Solar pp-neutrino flux with Borexino: results and implications
2015
International audience; Measurement of the Solar pp-neutrino flux completed the measurement of Solar neutrino fluxes from the pp-chain of reactions in Borexino experiment. The result is in agreement with the prediction of the Standard Solar Model and the MSW/LMA oscillation scenario. A comparison of the total neutrino flux from the Sun with Solar luminosity in photons provides a test of the stability of the Sun on the 10(5) years time scale, and sets a strong limit on the power production by the unknown energy sources in the Sun.