Search results for "53"
showing 10 items of 2908 documents
Optimization of the JUNO liquid scintillator composition using a Daya Bay antineutrino detector
2021
To maximize the light yield of the liquid scintillator (LS) for the Jiangmen Underground Neutrino Observatory (JUNO), a 20 t LS sample was produced in a pilot plant at Daya Bay. The optical properties of the new LS in various compositions were studied by replacing the gadolinium-loaded LS in one antineutrino detector. The concentrations of the fluor, PPO, and the wavelength shifter, bis-MSB, were increased in 12 steps from 0.5 g/L and <0.01 mg/L to 4 g/L and 13 mg/L, respectively. The numbers of total detected photoelectrons suggest that, with the optically purified solvent, the bis-MSB concentration does not need to be more than 4 mg/L. To bridge the one order of magnitude in the detect…
Limiting Carleman weights and conformally transversally anisotropic manifolds
2020
We analyze the structure of the set of limiting Carleman weights in all conformally flat manifolds, 3 3 -manifolds, and 4 4 -manifolds. In particular we give a new proof of the classification of Euclidean limiting Carleman weights, and show that there are only three basic such weights up to the action of the conformal group. In dimension three we show that if the manifold is not conformally flat, there could be one or two limiting Carleman weights. We also characterize the metrics that have more than one limiting Carleman weight. In dimension four we obtain a complete spectrum of examples according to the structure of the Weyl tensor. In particular, we construct unimodular Lie groups whose …
Volume preserving mean curvature flows near strictly stable sets in flat torus
2021
In this paper we establish a new stability result for the smooth volume preserving mean curvature flow in flat torus $\mathbb T^n$ in low dimensions $n=3,4$. The result says roughly that if the initial set is near to a strictly stable set in $\mathbb T^n$ in $H^3$-sense, then the corresponding flow has infinite lifetime and converges exponentially fast to a translate of the strictly stable (critical) set in $W^{2,5}$-sense.
Nonlinear Liouville Problems in a Quarter Plane
2016
We answer affirmatively the open problem proposed by Cabr\'e and Tan in their paper "Positive solutions of nonlinear problems involving the square root of the Laplacian" (see Adv. Math. {\bf 224} (2010), no. 5, 2052-2093).
A Deadly Liaison between Oxidative Injury and p53 Drives Methyl-Gallate-Induced Autophagy and Apoptosis in HCT116 Colon Cancer Cells
2023
Methyl gallate (MG), which is a gallotannin widely found in plants, is a polyphenol used in traditional Chinese phytotherapy to alleviate several cancer symptoms. Our studies provided evidence that MG is capable of reducing the viability of HCT116 colon cancer cells, while it was found to be ineffective on differentiated Caco-2 cells, which is a model of polarized colon cells. In the first phase of treatment, MG promoted both early ROS generation and endoplasmic reticulum (ER) stress, sustained by elevated PERK, Grp78 and CHOP expression levels, as well as an upregulation in intracellular calcium content. Such events were accompanied by an autophagic process (16–24 h), where prolonging the …
$\Lambda_c^{\pm}$ production in pp collisions with a new fragmentation function
2020
Physical review / D D 101(11), 114021 (2020). doi:10.1103/PhysRevD.101.114021
Investigations of Anisotropic Flow Using Multiparticle Azimuthal Correlations in pp, p-Pb, Xe-Xe, and Pb-Pb Collisions at the LHC
2019
Measurements of anisotropic flow coefficients ($v_n$) and their cross-correlations using two- and multi-particle cumulant methods are reported in collisions of pp at $\sqrt{s} = 13$ TeV, p-Pb at $\sqrt{s_{_{\rm NN}}} = 5.02$ TeV, Xe-Xe at $\sqrt{s_{_{\rm NN}}} = 5.44$ TeV, and Pb-Pb at $\sqrt{s_{_{\rm NN}}} = 5.02$ TeV recorded with the ALICE detector. The multiplicity dependence of $v_n$ is studied in a very wide range from 20 to 3000 particles produced in the mid-rapidity region $|��|<0.8$ for the transverse momentum range $0.2 < p_{\rm T} < 3.0$ GeV/$c$. An ordering of the coefficients $v_2 > v_3 > v_4$ is found in pp and p-Pb collisions, similar to that seen in large coll…
First measurement of quarkonium polarization in nuclear collisions at the LHC
2021
The polarization of inclusive J/$\psi$ and $\Upsilon(1{\rm S})$ produced in Pb-Pb collisions at $\sqrt{s_{\rm{NN}}}=5.02$ TeV at the LHC is measured with the ALICE detector. The study is carried out by reconstructing the quarkonium through its decay to muon pairs in the rapidity region $2.5<y<4$ and measuring the polar and azimuthal angular distributions of the muons. The polarization parameters $\lambda_{\theta}$, $\lambda_{\phi}$ and $\lambda_{\theta\phi}$ are measured in the helicity and Collins-Soper reference frames, in the transverse momentum interval $2<p_{\rm T}<10$ GeV/$c$ and $p_{\rm T}<15$ GeV/$c$ for the J/$\psi$ and $\Upsilon(1{\rm S})$, respectively. The polarization parameter…
Hepatocellular cancer cell lines, Hep-3B and Hep-G2 display the pleiotropic response to resveratrol and berberine
2022
Purpose Human carcinoma cells with different p53 status exposed to a combination of bioactive substances, resveratrol and berberine, revealed different responses in cell viability via p53-dependant apoptosis pathway activation. Materials and methods Using 3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium (MTS) assay, we investigated various and opposing effects in hepatocellular carcinoma cells, Hep-G2 and Hep-3B with different p53-status. Results Cells decreased in viability after treatment with dose-dependent concentrations of resveratrol and berberine. Hep-3B p53 mutants were more sensitive in comparison to the p53 wild type Hep-G2 cell line. A syne…
Epigenetic siRNA and Chemical Screens Identify SETD8 Inhibition as a Therapeutic Strategy for p53 Activation in High-Risk Neuroblastoma
2017
Given the paucity of druggable mutations in high-risk neuroblastoma (NB), we undertook chromatin-focused small interfering RNA and chemical screens to uncover epigenetic regulators critical for the differentiation block in high-risk NB. High-content Opera imaging identified 53 genes whose loss of expression led to a decrease in NB cell proliferation and 16 also induced differentiation. From these, the secondary chemical screen identified SETD8, the H4K20me1 methyltransferase, as a druggable NB target. Functional studies revealed that SETD8 ablation rescued the pro-apoptotic and cell-cycle arrest functions of p53 by decreasing p53K382me1, leading to activation of the p53 canonical pathway. I…