Search results for "562"

ChemInform Abstract: Synthesis and Antineoplastic Activity of New 4-Diazopyrazole Derivatives.

2010

Several new 4-diazopyrazole derivatives were synthesized by reaction of 1-(R-substituted)phenyl-3-methyl-5-benzamidopyrazoles with a sevenfold excess of nitrous acid in acetic media. The compounds were tested at 20 microM concentration for their antineoplastic activity in vitro against Raji (human Burkitt lymphoma), K562 (human chronic myelogenous leukemia) and U937 (human histiocytic lymphoma) cell lines. They showed a percent of growth inhibition in the range 23.4-100%.

Fama posthuma a la vida y muerte del doctor frey Lope Felix de Vega Carpio y elogios panegiricos a la inmortalidad de sv nombre / escritos por los ma…

1636

Sign.: œ8, œœ4, A-Z8, Aa-Cc8, Dd4 Errates tip. a la fol. Port. orlada Escut xill. del Duc de Sesa a la f. [7

Composite nanoparticles based on hyaluronic acid chemically cross-linked with alpha,beta-polyaspartylhydrazide.

2007

In this paper, new composite nanoparticles based on hyaluronic acid (HA) chemically cross-linked with alpha,beta polyaspartylhydrazide (PAHy) were prepared by the use of a reversed-phase microemulsion technique. HA-PAHy nanoparticles were characterized by FT-IR spectroscopy, confirming the occurrence of the chemical cross-linking, dimensional analysis, and transmission electron micrography, showing a sub-micrometer size and spherical shape. Zeta potential measurements demonstrated the presence of HA on the nanoparticle surface. A remarkable affinity of the obtained nanoparticles toward aqueous media that simulate some biological fluids was found. Stability studies showed the absence of chem…

in vitro biological evaluation of folate-functionalized block copolymer micelles for selective anti-cancer drug delivery.

2008

The main objective of this study was to evaluate the ability of folic acid-functionalized diblock copolymer micelles to improve the delivery and uptake of two poorly water-soluble anti-tumor drugs, tamoxifen and paclitaxel, to cancer cells through folate receptor targeting. The diblock copolymer used in this study comprised a hydrophilic poly[2-(methacryloyloxy)ethyl phosphorylcholine] (MPC) block, carrying at the chain end the folate targeting moiety, and a pH-sensitive hydrophobic poly[2-(diisopropylamino)ethyl methacrylate] (DPA) block (FA-MPC-DPA). The drug-loading capacities of tamoxifen- and paclitaxel-loaded micelles were determined by high performance liquid chromatography and the m…

Cytotoxic effects of polyphenols from waste-water of extra virgin olive oil on human HL60 and K562 cell lines.

2009

Cell cooperation in coelomocyte cytotoxic activity of Paracentrotus lividus coelomocytes

2007

The coelomic fluid from the sea urchin Paracentrotus lividus contains several coelomocyte types including amoebocytes and uncoloured spherulocytes involved in immune defences. In the present paper, we show a Ca(2+)-dependent cytotoxic activity for the unfractionated coelomocytes assayed in vitro, with rabbit erythrocytes and the K562 tumour cell line. In a plaque-forming assay, whole coelomocyte preparations as well as density gradient separated coelomocyte populations revealed that cell populations enriched in uncoloured spherulocytes, exerted high cytotoxic activity by releasing lysins in the presence of amoebocytes. This cooperative effect could be dependent on soluble factors released b…

Programmed cell death (PCD) associated with the stilbene motif of arotinoids: discovery of novel apoptosis inducer agents possessing activity on mult…

2000

Considering that the stereochemistry of the C9-C10 alkenyl portion of natural 9-cis-RA, as the one of the olefinic moiety of the previously described isoxazole retinoid 4, seems of particular importance for their apoptotic activity, we prepared a novel class of TTNPB analogues bearing both the cis or trans configuration of the alkenyl portion. The compounds were evaluated in vitro for their cytotoxic and apoptotic activities. We discovered that the cis-TTNPB 9c possesses apoptotic activity comparable with that of the retinoid 4. Moreover, the amino arotinoid 16c showed potent apoptotic activity in HL60 promyelocytic leukemia cells. Interestingly, 16c proved to be a particularly potent apopt…

Comparative Proteome Profiling and Functional Analysis of Chronic Myelogenous Leukemia Cell Lines

2007

The aim of the present study was the molecular profiling of different Ph+ chronic myelogenous leukemia (CML) cell lines (LAMA84, K562, and KCL22) by a proteomic approach. By employing two-dimensional gel electrophoresis combined with mass spectrometry analysis, we have identified 191 protein spots corresponding to 142 different proteins. Among these, 63% were cancer-related proteins and 74% were described for the first time in leukemia cells. Multivariate analysis highlighted significant differences in the global proteomic profile of the three CML cell lines. In particular, the detailed analysis of 35 differentially expressed proteins revealed that LAMA84 cells preferentially expressed prot…

La transmissió lingüística intergeneracional a Castelló de la Plana i la Franja: La rellevància dels usos entre progenitors

2020

Fa 50 anys, a Conflicte lingüístic valencià, Rafael L. Ninyoles situava el trencament de la transmissió familiar del català com a resultat i manifestació externa de conflictes socials i de classes, especialment visibles enmig del procés de modernització econòmica i mobilitat social accelerada del País Valencià dels anys 60 del segle XX. En aquest article partim de dos estudis de cas quantitatius sobre la transmissió intergeneracional de les llengües a Castelló de la Plana i les comarques centrals de la Franja per a actualitzar el seu diagnòstic i matisar la visió d'aquest fenomen com a resultat de decisions dels progenitors imposades verticalment a la descendència. Hi proposem que els usos …

Rafael l. Ninyoles: Recorregut biogràfic i intel·lectual

2020

This article presents the biography and intellectual legacy of Valencian sociologist Rafael L. Ninyoles (1943- 2019). It reviews his formative itinerary, his early contributions to the field of the sociology of language, his latest contributions to the sociology of cities and cultural spaces, and his key involvement in the promoti-on and consolidation of the sociological study of Valencian society. The article includes a note on public acknowledgements to the author, plus an annex with a selective bibliography aimed at serving the interested reader and the posthumous diffusion of Ninyoles? oeuvre.