Search results for "562"
showing 10 items of 133 documents
Tiempos felices: Transformaciones en las tecnologías psicológicas de gobierno de la subjetividad
2020
This paper traces some inflections in the psy disciplines? discourses and technologies for the government of subjectivity during the last decades. It is focused on exploring different mechanisms through which psychological disciplines ?their discourses, techniques and practices? penetrate social life and contribute to establishing subject models consistent with transformations in the political and economic rationalities of late capitalism. Drawing on previous research in the field of gender politics and happiness discourses in the pop psychological culture, I track a line with three moments: i) the production of psychological individuality and identity normalization; ii) the proliferation o…
THE ANTINEOPLASTIC ROLE OF STAT5 INHIBITION IN BCRABL1-POSITIVE CELLS EXPOSED TO PIMOZIDE ALONE AND IN COMBINATION WITH DASATINIB AND PONATINIB
2021
EVEN though the last decades have seen the success of the targeted treatments for BCRABL1-positive Chronic Myeloid Leukemia (CML), with the outstanding achievement of placing selected patients into the so called treatment-free remission, a minor part of these subjects face TKI resistance and/or intolerance. Resistance is a challenging point in the clinical management of CML, occurring in approximately 10–20% of CML cases, due to several mechanisms, among which point mutations of the BCR‐ABL kinase domain, BCRABL overexpression or alternative splicing, sub-efficient plasma concentration of the inhibitor and abnormal drug efflux/influx. The Signal Transducer and Activators of Transcription (S…
Gestión del cuerpo y planificación urbana: Desplazamiento de significado en la reivención de cuepos y ciudades
2020
Contemporary cities have administrations increasingly marked by urban planning guidelines that are guided by business and marketing and, to attract investments and tourists, implement strategies that aim to homogenize, spectacularize and control urban space. However, other experiences in the city potentially build new meaning to it, which would escape those strategically planned, creating alternative possibilities of uses, diverging from the way thar are predicted and proposed by the governmental power in their urban marketing strategies. The article discusses how the occupation of urban spaces by transvestites for prostitution may imply reflections on the role of norms of gender in the (re…
La gestión en educación física. Dos modelos de gestión, el mismo individuo
2020
In the development of this writing, we intend to critically analyze the idea of management in Physical Education and problematize it with the issues of inclusion and inequality. To do this, first there is a brief etymological review of the concept of management, and then we analyze how Physical Education links management to economic and business Sciences. The analysis material used are books, manuals and articles on Physical Education management. From the analysis of this material, the second point of the work arises to explain two management models in Physical Education that we call: individual management and self-management. These models are presented as different and opposite, but in the…
V gamma 9V delta 2 T lymphocytes efficiently recognize and kill zoledronate-sensitized, imatinib-sensitive, and imatinib-resistant chronic myelogenou…
2010
Abstract Imatinib mesylate (imatinib), a competitive inhibitor of the BCR-ABL tyrosine kinase, is highly effective against chronic myelogenous leukemia (CML) cells. However, because 20–30% of patients affected by CML display either primary or secondary resistance to imatinib, intentional activation of Vγ9Vδ2 T cells by phosphoantigens or by agents that cause their accumulation within cells, such as zoledronate, may represent a promising strategy for the design of a novel and highly innovative immunotherapy capable to overcome imatinib resistance. In this study, we show that Vγ9Vδ2 T lymphocytes recognize, trogocytose, and efficiently kill imatinib-sensitive and -resistant CML cell lines pre…
Rompé tus barreras: Un análisis sobre el uso del coaching ontológico en la plataforma de entrenamiento de Nike en Buenos Aires
2020
In recent times, coaching has become relevant in heterogeneous discourses and practices in the economic, political and cultural fields of contemporary societies. Based on our ethnographic analysis of different training sessions on the Nike+ Run Club platform in Buenos Aires, in this article we study how ontological coaching operates in the field of sport and races. Then, we ask about how people who attend this platform appropriate coaching techniques to manage emotions, moods, and body effects according to the business entrepreneurship logic. Through this work, the ethnographic results are articulated with a reflection about the theory, practice, and values of the ontological coaching, wher…
Las formas cotidianas de la felicidad y sus mandatos: Pedagogías del pensamiento positivo, trabajo docente y subjetividad en el neoliberalismo contem…
2020
Positive thinking constitutes one of the great traditions that lead to the idea of the subject as an entrepreneur of himself and is perhaps one of the best that has successfully condensed cultural, political, social and pedagogical processes linked to reflection on well-being in this historical time. The teaching work is especially moved by the pregnancy of these perspectives that challenge the pedagogical field and the education workers as ?agents of change, or at least one more school available to give the discussion on well-being and happiness (yours and the students?) is celebrated and encouraged. In this article, I intend to understand what is being built as pedagogical discourses abou…
Party autonomy regarding jurisdiction under the property regimes regulations
2021
The main accomplishment of the Property Regimes Regulations lies in their bringing more coherence into the cross-border family law adjudication. In the field of international jurisdiction, they strive to align the competence in couples? patrimony disputes to that in succession and in separation proceedings, or else to align the competence of the courts to the applicable law. These tendencies are clearly visible in the Regulations? provisions on choice of court agreements. Namely, the Regulations allow for such agreements, but severely limit parties? choice and the possible effects of these clauses. When succession or separation proceedings are pending, it is often only possible to institute…
AGE6. Skin Ageing: Focus on the Role of Inflammatory Genetic Factors in Cutaneous Neoplasia
2014
AGE6. Skin Ageing: Focus on the Role of Inflammatory Genetic Factors in Cutaneous Neoplasia C. M. Gambino1, F. Crapanzano1, G. Accardi1, A. Aiello1, C. Virruso1, G. Pistone1, M. R. Bongiorno1, D. Lio1, C. R. Balistreri1, G. Candore1 1University of Palermo, Palermo, Italy Background: Skin aging is a complex process that involves intrinsic and exogenous causes. Photo-oxidative damage caused by UV is the leading cause of extrinsic aging of the skin, known as photo-ageing. UV damages can be linked mostly to overproduction of ROS that induces a complex molecular cascade able to accelerate physiological aging, determining a typical dermal/epidermal inflammation with an increased risk of getting s…
¿Quién está buscando su mejor versión? Coaching y psicología deportiva en el proceso de terapeutización de (y desde) el golf
2020
This article asks about the expansion of psychological, therapeutic and self-enhancement ethos through the networks and devices that configures middle and upper-middle classes, and about the ways in which this process is singled out starting from the encounter between coaching and psychology paradigms with golf fans, in contemporary Argentina. The empirical materials that support the analysis have been ethnographically produced from the interaction with golf players and coaches.