Search results for "56"

N-(INDAZOLYL)BENZAMIDO DERIVATIVES AS CDK1 INHIBITORS: DESIGN, SYNTHESIS, BIOLOGICAL ACTIVITY, AND MOLECULAR DOCKING STUDIES

2009

A series of N-1H-indazole-1-carboxamides has been synthesized and their effects on both CDK1/cyclin B and the K-562 (human chronic myelogenus leukemia) cell line were evaluated. Using a computational model, we have observed that all the most active compounds 9e, f, i-n exhibited the same binding mode of purvanalol A in the ATP-binding cleft. Although they were able to moderately inhibit the leukemic cell line K-562 and to show inhibitory activity against the Cdc2-Cyclin B kinase in the low micromolar range, they turned out to be non-cytotoxic against HuDe (IZSL) primary cell cultures from human derm. These preliminary results are quite encouraging in view of the low toxicity demonstrated by…

Gozos, y loores a la insigne virgen Santa Getrudis [sic] en su Capilla de la Zaydia.

El full orlat. Grav. xil. enmarcat de "Santa Getrudis la Magna", flanquejat per gerros amb flors. Text del goig a tres col. separades per filets.

Oratio funebris de laudibus Ioannis Medicis S.R.E. Cardinalis habita VII K. Dec. 1562 a Petro Victorio in aede Diui Laurentii Florentiae.

1562

Escut heràldic xil. a la port. Sign.: A4 Reclams

Aprites ekonomika sabiedriskajā ēdināšanā kā pelnītspēju veicinošais faktors.

2022

Lai nodrošinātu sabiedriskās ēdināšanas uzņēmumu ilgtspējīgu izaugsmi, resursu izmantošanai jākļūst gudrākai un ilgtspējīgākai. Ir skaidrs, ka agrākais ekonomikas izaugsmes lineārais modelis vairs neder mūsdienu globalizētās pasaules sabiedrības vajadzībām. Nav iespējams izveidot nākotni, ņemot par pamatu modeli „paņemt, uztaisīt, izmest”. Daudzi dabas resursi ir ierobežoti, un ir jāatrod veids, kā tos izmantot no vides un ekonomikas viedokļa ilgtspējīgi. Izmantot esošos resursus labākajā iespējamajā veidā ir arī uzņēmumu ekonomiskajās interesēs. Maģistra darba mērķis ir izpētīt aprites ekonomikas lomu sabiedriskās ēdināšanas uzņēmumos, sabiedrības informētības līmeni, paradumus un viedokli…

Fourth‐generation glucose sensors composed of copper nanostructures for diabetes management: A critical review

2022

Abstract More than five decades have been invested in understanding glucose biosensors. Yet, this immensely versatile field has continued to gain attention from the scientific world to better understand and diagnose diabetes. However, such extensive work done to improve glucose sensing devices has still not yielded desirable results. Drawbacks like the necessity of the invasive finger‐pricking step and the lack of optimization of diagnostic interventions still need to be considered to improve the testing process of diabetic patients. To upgrade the glucose‐sensing devices and reduce the number of intermediary steps during glucose measurement, fourth‐generation glucose sensors (FGGS) have be…

Bacon und die Naturphilosophie

1927

Resistir era y sigue siendo hoy día abrir paso a la victoria Del discurso del Dr. Negrín pronunciado el 18 de junio.

En la part esquerra el rostre de Negrín i en la dreta, en vermell, una frase del seu discurs

Españoles D. Juan Negrín Presidente del Consejo de Ministros, ha dicho en su discurso del 26 de febrero de 1938: ...

1938

En la part superior una bandera republicana i baix el discurs de Negrín

Apoptotic activity of isoespintanol derivatives in human polymorphonuclear cells

2016

Background: Inflammation is a complex physiopathologic response to different stimuli. Recently, some pharmacological strategies have been proposed that could be used for resolution of inflammation by enhancing apoptosis of inflammatory cells. Objectives: To study in vitro apoptotic activity of isoespintanol [ISO] and of two semi-synthetic derivatives, bromide isoespintanol [BrI] and demethylated isoespintanol [DMI], in human polymorphonuclear (PMN) cells. Methods: PMN were exposed to the different concentrations of ISO, BrI and DMI for 30 min in phosphate-buffered saline pH 7.4 containing 1 mg/mL glucose, 0.4 mM Mg2+, and 1.20 mM Ca2+. Viability was assessed by dimethylthiazol diphenyl tetr…

Pyrrolo[2,1-d][1,2,3,5]tetrazine-4(3H)-ones, a new class of azolotetrazines with potent antitumor activity.

2003

Pyrrolo[2,1-d][1,2,3,5]tetrazinones 10a-o, compounds that hold the deaza skeleton of the antitumor drug temozolomide, were prepared by reaction of 2-diazopyrroles 9 and isocyanates. Such a synthetic route represents, among those leading to azolotetrazinones reported so far, the only possible one since attempts to cyclize to the title ring system 2-amino-1-carbamoylpyrroles 11 or the mono substituted 2-triazenopyrrole 12 failed. Compounds 10 were screened at the National Cancer Institute (NCI) for their activity against a panel of about 60 human tumor cell lines. Most of them possess remarkable antineoplastic activity having GI(50) values in the low micromolar or sub-micromolar range and rea…