Search results for "57"
showing 10 items of 4186 documents
Sex Differences in the Behavioral and Synaptic Consequences of a Single in vivo Exposure to the Synthetic Cannabimimetic WIN55,212-2 at Puberty and A…
2019
Heavy cannabis consumption among adolescents is associated with significant and lasting neurobiological, psychological and health consequences that depend on the age of first use. Chronic exposure to cannabinoid agonists during the perinatal period or adolescence alters social behavior and prefrontal cortex (PFC) activity in adult rats. However, sex differences on social behavior as well as PFC synaptic plasticity after acute cannabinoid activation remain poorly explored. Here, we determined that the consequences of a single in vivo exposure to the synthetic cannabimimetic WIN55,212-2 differently affected PFC neuronal and synaptic functions after 24 h in male and female rats during the pube…
STEM CELLS FOR TREATMENT OF CARDIOVASCULAR DISEASES: AN UMBRELLA REVIEW OF RANDOMIZED CONTROLLED TRIALS
2021
AIMS:\ud \ud Stem cells are a promising therapy for various medical conditions. The literature regarding their adoption for the clinical care of cardiovascular diseases (CVD) is still conflicting. Therefore, our aim is to assess the strength and credibility of the evidence on clinical outcomes and application of stem cells derived from systematic reviews and meta-analyses of intervention studies in CVD.\ud \ud METHODS and RESULTS:\ud \ud Umbrella review of systematic reviews with meta-analyses of randomized controlled trials (RCTs) using placebo/no intervention as control group. For meta-analyses of RCTs, outcomes with a random-effect p-value< 0.05, the GRADE (Grading of Recommendations Ass…
Effects of exercise on life quality in a rheumatoid arthritis patient
2020
Rheumatoid arthritis (RA) is a chronic-degenerative disease characterized by symptoms that significantly impact on the functional capacity and thus, the ability to carry out daily functional activities reducing the quality of life (QoL). The aim was to evaluate the effects of a strength and conditioning (S&C) program on the quality of life (QoL), the self-perception disease impact, the self-fatigue perception and cardiovascular risk factors in a patient with rheumatoid arthritis (RA) and cardiovascular disease (CVD). 34-year-old woman (height: 1.40m; weight: 36.1kg) diagnosed with RA and CVD underwent a six-month S&C program with aerobic training 2-3 times a week in 1-3 sets of 5-15 minutes…
Epoxide Hydrolases: Structure, Function, Mechanism, and Assay
2005
Epoxide hydrolases are a class of enzymes important in the detoxification of genotoxic compounds, as well as in the control of physiological signaling molecules. This chapter gives an overview on the function, structure, and enzymatic mechanism of structurally characterized epoxide hydrolases and describes selected assays for the quantification of epoxide hydrolase activity.
Detoxication Strategy of Epoxide Hydrolase—The Basis for a Novel Threshold for Definable Genotoxic Carcinogens
2004
From our recent work on the three-dimensional structure of epoxide hydrolases we theoretically deduced the likelihood of a two-step catalytic mechanism that we and others have subsequently experimentally confirmed. Analysis of the rate of the two steps by us and by others show that the first step—responsible for removal of the reactive epoxide from the system—works extraordinarily fast (typically three orders of magnitude faster than the second step), sucking up the epoxide like a sponge. Regeneration of the free enzyme (the second step of the catalytic mechanism) is slow. This becomes a toxicological problem only at doses of the epoxide that titrate the enzyme out. Our genotoxicity work s…
Can Experimental Electron-Density Studies be Used as a Tool to Predict Biologically Relevant Properties of Low-Molecular Weight Enzyme Ligands?
2013
The case of protease inhibitor model compounds incorporating an aziridine or epoxide ring is used to exemplify how application of experimental electron-density techniques can be used to explain the biological properties of low-molecular weight enzyme ligands. This is furthermore seen in the light of a comparison of crystal and enzyme environments employing QM/MM computations to elucidate to which extent the properties in the crystal can be used to predict behavior in the biological surrounding.
Impact of operation condition on temperature distribution in single cell of polymer electrolyte fuel cell operated at higher temperature than usual
2016
For improving performance of the stationary Polymer Electrolyte Fuel Cell (PEFC) system, the cell operating temperature up to 90°C will be preferred in Japan during the period from 2020 to 2030. To understand the operation of the PEFC system under relatively high temperature conditions, detail heat and mass transfer analysis is required. The main focus of this study is to analyze the PEFC performance under operational conditions, such as initial operational temperature of cell (Tini), relative humidity of supply gas, and the cathode gas type, temperature distribution in a cell of PEFC (using Nafion membrane) under relatively higher operating temperature conditions. The in-plane temperature …
Behavior of carbohydrate-based material in black liquor during heating
2004
One industrial softwood Kraft black liquor was heat-treated (at 175 ?C and 190 ?C for 15-60 min) together with laboratory-made soda-AQ (wheat straw and reed canary grass) and Kraft (reed canary grass) black liquors (at 190 ?C for 30 min). The feedstock black liquors were characterized with respect to their polysaccharide (mainly xylem) and aliphatic carboxylic acid contents before and after the heat treatments. It was noted that, due to the higher amount of polysaccharides in the non-wood black liquors (8.2-16.6% of d.s) compared to that in the softwood black liquor (1.4% of d.s), the heat treatment in the former case resulted in a 5-30% increase in the amount of aliphatic acids formed by v…
Effects of lobeline on spatial learning in C57BL mice
2000
In the present study, the effect of lobeline on water maze performance in C57BL/6J mice have been evaluated. In the first experiment, subjects were 2-month old mice to which lobeline (3.5 and 7 mg/kg) had been administered SC along 5 days 15 min before daily training in the water maze. Results showed that lobeline did not have effects on the acquisition of the task. In the second experiment, effects of lobeline were compared in 2, 6 and 20-month old mice. In this experiment the drug was administered daily five days prior to the beginning of the task and during the five days of acquisition. Results indicated that 20-month old mice learned the spatial task more slowly than 2 and 6-month old m…
The Impact of Age on the Association Between Physical Activity and White Matter Integrity in Cognitively Healthy Older Adults
2020
Cognition emerges from coordinated processing among distributed cortical brain regions, enabled through interconnected white matter networks. Cortical disconnection caused by age-related decline in white matter integrity (WMI) is likely to contribute to age-related cognitive decline. Physical activity (PA) has been suggested to have beneficial effects on white matter structure. However, its potential to counteract age-related decline in WMI is not yet well established. The present explorative study analyzed if PA was associated with WMI in cognitively healthy older adults and if this association was modulated by age. Forty-four cognitively healthy older individuals (aged 60–88 years) with d…