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RESEARCH PRODUCT
Effects of lobeline on spatial learning in C57BL mice
M. C. BernalM.c. CarrascoRosa RedolatPaloma Vicenssubject
chemistry.chemical_compoundchemistryGeneral NeuroscienceAnesthesiaSpatial learningLobelineWater mazePsychologyC57bl 6jdescription
In the present study, the effect of lobeline on water maze performance in C57BL/6J mice have been evaluated. In the first experiment, subjects were 2-month old mice to which lobeline (3.5 and 7 mg/kg) had been administered SC along 5 days 15 min before daily training in the water maze. Results showed that lobeline did not have effects on the acquisition of the task. In the second experiment, effects of lobeline were compared in 2, 6 and 20-month old mice. In this experiment the drug was administered daily five days prior to the beginning of the task and during the five days of acquisition. Results indicated that 20-month old mice learned the spatial task more slowly than 2 and 6-month old mice and that lobeline treatment did not have a significant effect on this rate of learning.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2000-01-01 | Neuroscience Research Communications |