Search results for "57"
showing 10 items of 4186 documents
Management of chronic urticaria in children: a clinical guideline
2019
Abstract The aim of this guidance is to provide recommendations to clinicians and other interested parties on chronic urticaria in children. The Italian Society for Pediatrics (SIP), the Italian Society for Allergy and Immunology (SIAIP), the Italian Society for Pediatric dermatology (SIDerP) convened a multidisciplinary panel that prepared clinical guidelines for diagnosis and management of chronic urticaria in childhood. Key questions on epidemiology, natural history, diagnosis, and management were developed. The literature was systematically searched and evaluated, recommendations were rated and algorithms for diagnosis and treatment were developed. The recommendations focus on identific…
Evaluation of varicella vaccine effectiveness as public health tool for increasing scientific evidence and improving vaccination programs
2020
Brazil; Chickenpox Vaccine; Humans; Immunization Programs; Public Health; Vaccination; Chickenpox; Viral Vaccines.
Insulin resistance aggravates atherosclerosis by reducing vascular smooth muscle cell survival and increasing CX3CL1/CX3CR1 axis.
2014
Aims Insulin resistance (IR) is a major risk factor for cardiovascular disease and atherosclerosis. Life-threatening acute events are mainly due to rupture of unstable plaques, and the role of vascular smooth muscle cells (VSMCs) in this process in IR, Type 2 diabetes mellitus, and metabolic syndrome (T2DM/MetS) has not been fully addressed. Therefore, the role of VSMC survival in the generation of unstable plaques in T2DM/MetS and the involvement of inflammatory mediators was investigated. Methods and results Defective insulin receptor substrate 2 (IRS2)-mediated signalling produced insulin-resistant VSMCs with reduced survival, migration, and higher apoptosis than control cells. Silencing…
Mielocintilografia com RIHSA no diagnóstico de processos patológicos intra-raqueanos
1968
O estudo de 214 mielocintilografias feitas em 200 pacientes permitiu aos autores chegar às seguintes conclusões: 1) a mielocintilografia com RIHSA - 131I oferece novas possibilidades no campo do diagnóstico neurológico, principalmente no que tange aos processos expansivos, inflamatorios e malformações, sendo limitadas suas possibilidades no diagnóstico de hérnias dos núcleos pulposos; 2) a mielocintilografia não substitui métodos mielográficos convencionais, os dois métodos devendo ser usados de maneira a se completarem; 3) há casos em que a mielocintilografia com RIHSA apresenta vantagem sobre a mielografia com os meios de contraste positivos, principalmente no diagnóstico de aracnoidites,…
A targeted apoB38.9 mutation in mice is associated with reduced hepatic cholesterol synthesis and enhanced lipid peroxidation.
2006
Familial hypobetalipoproteinemia (FHBL) due to truncation-specifying mutations of apolipoprotein B (apoB), which impair hepatic lipid export in very low-density lipoprotein (VLDL) particles, is associated with fatty liver. In an FHBL-like mouse with the apoB38.9 mutation, fatty liver develops despite reduced hepatic fatty acid synthesis. However, hepatic cholesterol contents in apoB38.9 mice are normal. We found that cholesterogenic enzymes (3-hydroxy-3-methylglutaryl-coenzyme A reductase, sterol-C5-desaturase, and 7-dehydrocholesterol reductase) were consistently downregulated in two separate expression-profiling experiments using a total of 19 mice ( n = 7 each for apob+/+and apob+/38.9, …
Dietary cholate increases plasma levels of apolipoprotein B in mice by posttranscriptional mechanisms
2001
To induce atherogenesis in mice, a high fat (HF) diet is supplemented with cholic acid (CA), which increases apoB-containing particles and lower apoA-I-containing particles. HF diet without CA increases levels of both HDL and LDL, suggesting that CA may be responsible for the elevation of LDL and lowering of HDL. The mechanism of dietary CA-induced lowering of apoA-I-containing particles has recently been reported. In this study, we examined the mechanism of CA- and HF-induced elevation of apoB-containing lipoproteins in mice. Mice were fed the following four diets: control chow (C), high fat high cholesterol, (HF), control and 0.5% cholate (CA), and HF + CA. Dietary CA increased the plasma…
Application of Supervised Machine Learning for Behavioral Biomarkers of Autism Spectrum Disorder Based on Electrodermal Activity and Virtual Reality
2020
[EN] Objective: Sensory processing is the ability to capture, elaborate, and integrate information through the five senses and is impaired in over 90% of children with autism spectrum disorder (ASD). The ASD population shows hyper¿hypo sensitiveness to sensory stimuli that can generate alteration in information processing, affecting cognitive and social responses to daily life situations. Structured and semi-structured interviews are generally used for ASD assessment, and the evaluation relies on the examiner¿s subjectivity and expertise, which can lead to misleading outcomes. Recently, there has been a growing need for more objective, reliable, and valid diagnostic measures, such as biomar…
Voluntary and Involuntary Attention in Bistable Visual Perception: A MEG Study
2020
In this study, voluntary and involuntary visual attention focused on different interpretations of a bistable image, were investigated using magnetoencephalography (MEG). A Necker cube with sinusoidally modulated pixels' intensity in the front and rear faces with frequencies 6.67 Hz (60/9) and 8.57 Hz (60/7), respectively, was presented to 12 healthy volunteers, who interpreted the cube as either left- or right-oriented. The tags of these frequencies and their second harmonics were identified in the average Fourier spectra of the MEG data recorded from the visual cortex. In the first part of the experiment, the subjects were asked to voluntarily control their attention by interpreting the cu…
Inspiratory and Lower-Limb Strength Importance in Mountain Ultramarathon Running. Sex Differences and Relationship with Performance
2020
The study was aimed at comparing lower-limb strength and respiratory parameters between male and female athletes and their interaction with performance in a 107 km mountain ultramarathon. Forty seven runners (29 males and 18 females
Effects of High Frequency Repetitive Transcranial Magnetic Stimulation (HF-rTMS) on Delay Discounting in Major Depressive Disorder: An Open-Label Unc…
2019
Background: Delay discounting (DD) refers to the decrease of a present subjective value of a future reward as the delay of its delivery increases. Major depressive disorder (MDD), besides core emotional and physical symptoms, involves difficulties in reward processing. Depressed patients often display greater temporal discounting rates than healthy subjects. Repetitive transcranial magnetic stimulation (rTMS) is a non-invasive brain stimulation technique applied in several countries to adult patients with treatment resistant depression. Studies suggest that this technique can be used to modulate DD, but no trial has assessed its effects on depressed patients. Methods: In this open-label unc…