Search results for "57"
showing 10 items of 4186 documents
Does predictability matter? Effects of cue predictability on neurocognitive mechanisms underlying prospective memory
2015
Prospective memory (PM) represents the ability to successfully realize intentions when the appropriate moment or cue occurs. In this study, we used event-related potentials (ERPs) to explore the impact of cue predictability on the cognitive and neural mechanisms supporting PM. Participants performed an ongoing task and, simultaneously, had to remember to execute a pre-specified action when they encountered the PM cues. The occurrence of the PM cues was predictable (being signalled by a warning cue) for some participants and was completely unpredictable for others. In the predictable cue condition, the behavioural and ERP correlates of strategic monitoring were observed mainly in the ongoing…
An Overview of Asthma and COVID-19: Protective Factors Against SARS-COV-2 in Pediatric Patients.
2021
Coronavirus disease 2019 (COVID-19) is a pandemic infectious disease caused by severe acute respiratory syndrome coronavirus SARS-COV-2. Aberrant innate immunity response and cytokine storm are responsible for the syndrome. Apparently, in asthmatic patients, the inadequate antiviral immune response and the tendency for asthma exacerbation evoked by common respiratory viruses could explain increased susceptibility to SARS-COV-2 infection. However, asthma has not been suggested to be a risk factor in COVID-19 patients. Therefore, in asthmatic patients some potential protective mechanisms against SARS-COV-2 have been hypothesized, like type 2 immune response, number of eosinophils, overproduct…
Effects of training on bone metabolism in young athletes
2021
Purpose. This study investigated the effects of two types of training on the bone formation marker of osteocalcin and the bone resorption marker of tartrate-resistant acid phosphatase isoenzyme 5b (TRAP5b) in young track and field boys and girls. Methods. The 14-year-old group (10 boys, 10 girls) performed first time an intensive and supervised 8-week plyometric training. In the 17-year-old group (13 athletic boys, 6 control boys, 12 athletic girls, 6 control girls), the normal many-sided track and field training lasted 6 months. Results. Significant increases were noticed in osteocalcin (p < 0.01) both in younger boys and girls. The 20-m sprint performance improved in girls (p < 0.01) and …
Physical inactivity increases oxidative stress, endothelial dysfunction, and atherosclerosis.
2005
Objective— Sedentary lifestyle is associated with increased cardiovascular events. The underlying molecular mechanisms are incompletely understood. Reactive oxygen species (ROS) contribute to endothelial dysfunction and atherosclerosis. An important source of vascular ROS is the NADPH oxidase. Methods and Results— C57BL6 mice were subjected to regular housing (physical inactivity) or voluntary training on running wheels (6 weeks). Inactivity increased vascular lipid peroxidation to 148±9% and upregulated superoxide release to 176±17% (L-012 chemiluminescence) and 188±29% (cytochrome C reduction assay), respectively. ROS production was predominantly increased in the endothelium and the medi…
Enterobacter cloacae administration induces hepatic damage and subcutaneous fat accumulation in high-fat diet fed mice.
2018
Accumulating evidence indicates that gut microbiota plays a significant role in obesity, insulin resistance and associated liver disorders. Family Enterobacteriaceae and especially Enterobacter cloacae strain B29 have been previously linked to obesity and hepatic damage. The underlying mechanisms, however, remain unclear. Therefore, we comprehensively examined the effects of E. cloacae subsp. cloacae (ATCC® 13047™) administration on host metabolism of mice fed with high-fat diet (HFD). C57BL/6N mice were randomly divided into HFD control, chow control, and E. cloacae treatment groups. The E. cloacae treatment group received live bacterial cells in PBS intragastrically twice a week, every ot…
Topological canal foliations
2019
Regular canal surfaces of $\mathbb{R}^3$ or $\mathbb{S}^3$ admit foliations by circles: the characteristic circles of the envelope. In order to build a foliation of $\mathbb{S}^3$ with leaves being canal surfaces, one has to relax the condition “canal” a little (“weak canal condition”) in order to accept isolated umbilics. Here, we define a topological condition which generalizes this “weak canal” condition imposed on leaves, and classify the foliations of compact orientable 3-manifolds we can obtain this way.
Antioxidant Therapies and Oxidative Stress in Friedreich´s Ataxia: The Right Path or Just a Diversion?
2020
Friedreich's ataxia is the commonest autosomal recessive ataxia among population of European descent. Despite the huge advances performed in the last decades, a cure still remains elusive. One of the most studied hallmarks of the disease is the increased production of oxidative stress markers in patients and models. This feature has been the motivation to develop treatments that aim to counteract such boost of free radicals and to enhance the production of antioxidant defenses. In this work, we present and critically review those 'antioxidant' drugs that went beyond the disease's models and were approved for its application in clinical trials. The evaluation of these trials highlights some …
La desheredación del menor de edad
2021
This work aims to answer the eternal question of the disinheritance of the child under legal age. To this end, we will approach the institute of disinheritance, its foundation and its jurisprudential evolution. We will also address the capacity and responsibility of the child under legal age and the emancipated minor. Subsequently, we will carry out the study of the disinheritance of the child under legal age, subject to the whim of the specific disinherited causes, since each of the causes provided for in art. 853 Spanish Civil Code are endowed with their own idiosyncrasy, being very complicated, if not impossible, to deal with the subject of this work apart from the vicissitudes that can …
Validating Habitual and Goal-Directed Decision-Making Performance Online in Healthy Older Adults
2021
Everyday decision-making is supported by a dual-system of control comprised of parallel goal-directed and habitual systems. Over the past decade, the two-stage Markov decision task has become popularized for its ability to dissociate between goal-directed and habitual decision-making. While a handful of studies have implemented decision-making tasks online, only one study has validated the task by comparing in-person and web-based performance on the two-stage task in children and young adults. To date, no study has validated the dissociation of goal-directed and habitual behaviors in older adults online. Here, we implemented and validated a web-based version of the two-stage Markov task usi…
Clinical Onset and Multiple Sclerosis Relapse after SARS-CoV-2 Infection
2021
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has been associated with several neurological disorders including headache, facial palsy, encephalitis, stroke, demyelinating disorders. The present report will discuss cases of multiple sclerosis (MS) onset and relapse both beginning early after SARS-CoV-2 infection. In both cases, magnetic resonance imaging (MRI) showed widespread bilateral subcortical and periventricular active lesions. Serum IgG against SARS-CoV-2 Spike antigens confirmed seroconversion with titers that are considered not definitely protective against possible reinfection. We hypothesize that SARS-CoV-2 infection, as previously reported for other vir…