Search results for "58"
showing 10 items of 2229 documents
Dexamethasone premedication suppresses vaccine-induced immune responses against cancer
2020
ABSTRACT Glucocorticosteroids (GCS) have an established role in oncology and are administered to cancer patients in routine clinical care and in drug development trials as co-medication. Given their strong immune-suppressive activity, GCS may interfere with immune-oncology drugs. We are developing a therapeutic cancer vaccine, which is based on a liposomal formulation of tumor-antigen encoding RNA (RNA-LPX) and induces a strong T-cell response both in mice as well as in humans. In this study, we investigated in vivo in mice and in human PBMCs the effect of the commonly used long-acting GCS Dexamethasone (Dexa) on the efficacy of this vaccine format, with a particular focus on antigen-specif…
Citizens' Communication Habits and Use of ICTs During Crises and Emergencies
2014
In this article, citizens’ communication habits and use of information and communication technologies during crises and emergencies are discussed from the perspective of community resilience. The topic is approached qualitatively by exploring citizens’ perceptions, and the data were gathered by means of focus groups in storm-prone and flood-prone areas in Finland. The results indicate that citizens consider emergency communication to be mostly unidirectional: from authorities to the public. However, because crises are often complex and fast developing, cooperation among response organizations and citizen groups is needed to coproduce safety and in adapting to changing situations. Organizati…
Exploring aesthetics, design, and experience in the age of semiotic technology
2018
Semiotics undergirds understanding of how people experience life (in both general and specific contexts) and thus impacts choices in regard to technology and its design. The papers in this issue draw on historical and contemporary scholarship of philosophy, practices, and theories in aesthetics, embodiment, and art experience in exploring the intersection of humans and technology.
The Rocky Road of Growing into Contemporary Citizenship: Dewey, Gramsci, and the Method of Democracy
2015
Characterized by globalization, increasing pluralism, and new complexities of citizenship, the contemporary world poses challenges to the ways in which we conceptualize of the processes of searching for shared solutions to ever-complicated social problems. While the political rhetoric emphasizes the value of citizens’ participation, engagement, and “voices,” there are increasing feelings of frustration, incapacity, and disinterest on behalf of the citizens regarding the supposed eff ects of their political engagement. In order to conceptually grasp the problem of searching for shared solutions and the related challenges to education, we draw on John Dewey’s idea of the method of democracy a…
ICT competences in university students in the field of education and its relationship with learning strategies
2016
Este estudio se enmarca en el contexto universitario, y concretamente en los estudiantes, ya que son los actores principales de su proceso de aprendizaje. El objetivo se centra en analizar las competencias en TIC (tecnológicas, pedagógicas y éticas) de estudiantes universitarios del ámbito de la Educación y su relación con las Estrategias de Aprendizaje. Además, se tienen en cuenta en el planteamiento desarrollado determinadas variables personales y contextuales claves. La población de referencia la constituyen los estudiantes universitarios de titulaciones pertenecientes al ámbito de la Educación de la Universidad de Valencia. La información se ha recogido a través de cuestionarios. Se ha …
Nietzsche i l'escepticisme : assaig d'aclariment d'una pretesa contradicció
2021
S'ha afirmar sovim que en marhia de teoria del coneixemem, Nietzsche és un esckptic. En aquest anide es fa un acurat repil.s de !'obra nictncheana a la cerca de les sentencies en pro o en contra de l'escepticismc, on les posicions en contra d'aqucst són especialment abundases en contradicció amh aquclles intcrprctacions. En el curs d'aqucst recorregut s'esbossa el conccpte nietzscheà de filosofia i la diferCncia entre aquesta i la ciCncia. La tesi final és que Nietzsche considera l'escepticismc una condició necesüria, perO no suficient, de la vcrtadcra filosofia. la filosofia sobirana i disciplinadora de la cultura. Així es dissoldrJ. la contradicció entre les interpretacions de !'autor com…
L'espace de liberté comme mesure synthétique du développement territorial durable
2011
By discussing the concept of development itself, authors propose two synthetic indexes relying on estimation of potential: Development Space Value and Development Space Creation Under the weak hypothesis that any successful development improves future possibilities, changes in potential are a good development measure. In their path, authors show how development space is tied with freedom: a shrink in it results mechanically in indexes fall. So, "sustainable" and "economic" become two sides of same piece rather than enemies. Reliable in simulations, the approach is to be tested in real conditions, to verify full data availability and to secure calculating methods.
The role of age and digital competence on the use of online health and social care services: A cross-sectional population-based survey
2022
Objective Online health and social care services are getting widespread which increases the risk that less advantaged groups may not be able to access these services resulting in digital exclusion. We examined the combined effects of age and digital competence on the use of online health and social care services. Methods We used a large representative population-based sample of 4495 respondents from Finland. Paper-based self-assessment questionnaire with an online response option was mailed to participants. The associations were analyzed using survey weighted logistic regression, exploring potential non-linear effects of age and controlling for potential sex differences. Results Higher age,…
La destrucció del patrimoni artístic i la seua reconstrucció. Un exercici de microhistòria: el cas de Llíria i la Confraria de la Sang (1936-1949)
2020
The problem of artistic destruction and its reconstruction has been little studied. Using a microhistorical analysis method, we study the town of Lliria (Valencia) and its brotherhood of ?La Sang de Jesucrist? (had a great heritage from the 16th to the 19th centuries), and we also analyze how and why this destruction and reconstruction was generated during the context of the civil war. We use and combine different sources (public of the ?Causa General? and private of the ?Minute Books?) for this research, with the intention of specifying the analysis of this complex process. We also explain social and artistic relationships of these two processes, that help us study the workshops of the mos…