Search results for "59"
showing 10 items of 1607 documents
The ubiquitin-specific protease USP8 is critical for the development and homeostasis of T cells
2015
The modification of proteins by ubiquitin has a major role in cells of the immune system and is counteracted by various deubiquitinating enzymes (DUBs) with poorly defined functions. Here we identified the ubiquitin-specific protease USP8 as a regulatory component of the T cell antigen receptor (TCR) signalosome that interacted with the adaptor Gads and the regulatory molecule 14-3-3β. Caspase-dependent processing of USP8 occurred after stimulation of the TCR. T cell-specific deletion of USP8 in mice revealed that USP8 was essential for thymocyte maturation and upregulation of the gene encoding the cytokine receptor IL-7Rα mediated by the transcription factor Foxo1. Mice with T cell-specifi…
Status of Nordic research on simulation-based learning in healthcare: an integrative review
2018
This article is distributed under the terms of the Creative Commons Attribution 4.0 International License. Background. Based on common geography, sociopolitics, epidemiology, and healthcare services, the Nordic countries could benefit from increased collaboration and uniformity in the development of simulation-based learning (SBL). To date, only a limited overview exists on the Nordic research literature on SBL and its progress in healthcare education. Therefore, the aim of this study is to fill that gap and suggest directions for future research. Methods. An integrative review design was used. A search was conducted for relevant research published during the period spanning from 1966 to Ju…
Characterization of Legal Psychology through psychology journals included in Criminology & Penology and Law categories of Web of Science
2017
[EN]: The objective of this work is to learn about the most relevant aspects that characterize contemporary Legal Psychology throughout the study of journals included in the WoS between the years 2009 and 2014 re-lated with the area of Psychology. The number of selected publications is 16, mainly from the USA and Great Britain. The results show an increase in the number of works and authors, a greater collaboration and a growth in medium productors. It exists a major presence of men in editorial boards and as authors, outstanding the figures of T. Ward in 2009 and A. Vrij in 2014. According to the analysis of key words the most relevant themes during these years have been Crime, Conduct, Wo…
Estrategias de compensación en adultos mayores: Diferencias sociodemográficas y en función de la reserva cognitiva
2015
Resumen: Los terminos de reserva cognitiva y compensacion, han sido utilizados en una amplia variedad de situaciones en la literatura cientifica para referirse a la superacion o reduccion de las perdidas o deficits en diferentes mecanismos y procesos como es la memoria. A traves del Memory Compensation Questionnaire (MCQ), se pretende analizar los diferentes mecanismos de compensacion en relacion con ciertas variables sociodemograficas (edad, genero y nivel educativo) de una muestra espanola y establecer, a partir de una medida combinada de reserva cognitiva (RC), las diferencias existentes entre sujetos con alta y baja reserva en el uso de mecanismos de compensacion. Se evaluo a 264 sujeto…
Pre-invasion history and demography shape the genetic variation in the insecticide resistance-related acetylcholinesterase 2 gene in the invasive Col…
2012
Abstract Background Invasive pest species offers a unique opportunity to study the effects of genetic architecture, demography and selection on patterns of genetic variability. Invasive Colorado potato beetle (Leptinotarsa decemlineata) populations have experienced a rapid range expansion and intense selection by insecticides. By comparing native and invasive beetle populations, we studied the origins of organophosphate (OP) resistance-associated mutations in the acetylcholinesterase 2 (AChE2) gene, and the role of selection and demography on its genetic variability. Results Analysis of three Mexican, two US and five European populations yielded a total of 49 haplotypes. Contrary to the exp…
Relationships of gag-pol diversity between Ty3/Gypsy and Retroviridae LTR retroelements and the three kings hypothesis
2008
Abstract Background The origin of vertebrate retroviruses (Retroviridae) is yet to be thoroughly investigated, but due to their similarity and identical gag-pol (and env) genome structure, it is accepted that they evolve from Ty3/Gypsy LTR retroelements the retrotransposons and retroviruses of plants, fungi and animals. These 2 groups of LTR retroelements code for 3 proteins rarely studied due to the high variability – gag polyprotein, protease and GPY/F module. In relation to 3 previously proposed Retroviridae classes I, II and II, investigation of the above proteins conclusively uncovers important insights regarding the ancient history of Ty3/Gypsy and Retroviridae LTR retroelements. Resu…
Gypsy endogenous retrovirus maintains potential infectivity in several species of Drosophilids.
2008
Abstract Background Sequences homologous to the gypsy retroelement from Drosophila melanogaster are widely distributed among drosophilids. The structure of gypsy includes an open reading frame resembling the retroviral gene env, which is responsible for the infectious properties of retroviruses. Results In this study we report molecular and phylogeny analysis of the complete env gene from ten species of the obscura group of the genus Drosophila and one species from the genus Scaptomyza. Conclusion The results indicate that in most cases env sequences could produce a functional Env protein and therefore maintain the infectious capability of gypsy in these species.
Propuestas teóricas en la investigación sobre acoso escolar: una revisión
2013
Four decades of research into peer bullying have produced an extensive body of knowledge. This work attempts to provide an integrative theoretical framework, which includes the specific theories and observations. The main aim is to organize the available knowledge in order to guide the development of effective interventions. To that end, several psychological theories are described that have been used and/or adapted with the aim of understanding peer bullying. All of them, at different ecological levels and different stages of the process, may describe it in terms of the relational dynamics of power. It is concluded that research needs to take this integrative framework into account, that i…