Search results for "5aR*"
showing 10 items of 204 documents
Oral N-acetylcysteine reduces bleomycin-induced lung damage and mucin Muc5ac expression in rats
2003
Oxidative stress is involved in the pathogenesis of pulmonary fibrosis, therefore antioxidants may be of therapeutic value. Clinical work indicates that N ‐acetylcysteine (NAC) may be beneficial in this disease. The activity of this antioxidant was examined on bleomycin-induced lung damage, mucus secretory cells hyperplasia and mucin Muc5ac gene expression in rats. NAC (3 mmol·kg−1·day−1) or saline was given orally to Sprague-Dawley rats for 1 week prior to a single intratracheal instillation of bleomycin (2.5 U·kg−1) and for 14 days postinstillation. NAC decreased collagen deposition in bleomycin-exposed rats (hydroxyproline content was 4,257±323 and 3,200±192 µg·lung−1 in vehicle- and NAC…
Phosphodiesterase 4 inhibition decreases MUC5AC expression induced by epidermal growth factor in human airway epithelial cells
2005
Background: A common pathological feature of chronic inflammatory airway diseases such as asthma and chronic obstructive pulmonary disease (COPD) is mucus hypersecretion. MUC5AC is the predominant mucin gene expressed in healthy airways and is increased in asthmatic and COPD patients. Recent clinical trials indicate that phosphodiesterase type 4 (PDE4) inhibitors may have therapeutic value for COPD and asthma. However, their direct effects on mucin expression have been scarcely investigated. Methods: MUC5AC mRNA and protein expression were examined in cultured human airway epithelial cells (A549) and in human isolated bronchial tissue stimulated with epidermal growth factor (EGF; 25 ng/ml).…
Jordan Decompositions of Tensors
2022
We expand on an idea of Vinberg to take a tensor space and the natural Lie algebra which acts on it and embed them into an auxiliary algebra. Viewed as endomorphisms of this algebra we associate adjoint operators to tensors. We show that the group actions on the tensor space and on the adjoint operators are consistent, which endows the tensor with a Jordan decomposition. We utilize aspects of the Jordan decomposition to study orbit separation and classification in examples that are relevant for quantum information.
Existence and uniqueness of global classical solutions to a two species cancer invasion haptotaxis model
2017
We consider a haptotaxis cancer invasion model that includes two families of cancer cells. Both families, migrate on the extracellular matrix and proliferate. Moreover the model describes an epithelial-to-mesenchymal-like transition between the two families, as well as a degradation and a self-reconstruction process of the extracellular matrix. We prove positivity and conditional global existence and uniqueness of the classical solutions of the problem for large initial data.
Calder\'on's problem for p-Laplace type equations
2016
We investigate a generalization of Calder\'on's problem of recovering the conductivity coefficient in a conductivity equation from boundary measurements. As a model equation we consider the p-conductivity equation with p strictly between one and infinity, which reduces to the standard conductivity equation when p equals two, and to the p-Laplace equation when the conductivity is constant. The thesis consists of results on the direct problem, boundary determination and detecting inclusions. We formulate the equation as a variational problem also when the conductivity may be zero or infinity in large sets. As a boundary determination result we recover the first order derivative of a smooth co…
Linearized Calder\'on problem and exponentially accurate quasimodes for analytic manifolds
2020
In this article we study the linearized anisotropic Calder\'on problem on a compact Riemannian manifold with boundary. This problem amounts to showing that products of pairs of harmonic functions of the manifold form a complete set. We assume that the manifold is transversally anisotropic and that the transversal manifold is real analytic and satisfies a geometric condition related to the geometry of pairs of intersecting geodesics. In this case, we solve the linearized anisotropic Calder\'on problem. The geometric condition does not involve the injectivity of the geodesic X-ray transform. Crucial ingredients in the proof of our result are the construction of Gaussian beam quasimodes on the…
Le cône diamant symplectique
2009
Resume Si n + est le facteur nilpotent d'une algebre semi-simple g , le cone diamant de g est la description combinatoire d'une base d'un n + module indecomposable naturel. Cette notion a ete introduite par N.J. Wildberger pour sl ( 3 ) , le cone diamant de sl ( n ) est decrit dans Arnal (2006) [2] , celui des algebres semi-simples de rang 2 dans Agrebaoui (2008) [1] . Dans cet article, nous generalisons ces constructions au cas des algebres de Lie sp ( 2 n ) . Les tableaux de Young semi-standards symplectiques ont ete definis par C. De Concini (1979) [4] , ils forment une base de l'algebre de forme de sp ( 2 n ) . Nous introduisons ici la notion de tableaux de Young quasi standards symplec…
Combinatorial Gray codes for classes of pattern avoiding permutations
2007
The past decade has seen a flurry of research into pattern avoiding permutations but little of it is concerned with their exhaustive generation. Many applications call for exhaustive generation of permutations subject to various constraints or imposing a particular generating order. In this paper we present generating algorithms and combinatorial Gray codes for several families of pattern avoiding permutations. Among the families under consideration are those counted by Catalan, Schr\"oder, Pell, even index Fibonacci numbers and the central binomial coefficients. Consequently, this provides Gray codes for $\s_n(\tau)$ for all $\tau\in \s_3$ and the obtained Gray codes have distances 4 and 5.
Muckenhoupt $A_p$-properties of distance functions and applications to Hardy-Sobolev -type inequalities
2017
Let $X$ be a metric space equipped with a doubling measure. We consider weights $w(x)=\operatorname{dist}(x,E)^{-\alpha}$, where $E$ is a closed set in $X$ and $\alpha\in\mathbb R$. We establish sharp conditions, based on the Assouad (co)dimension of $E$, for the inclusion of $w$ in Muckenhoupt's $A_p$ classes of weights, $1\le p<\infty$. With the help of general $A_p$-weighted embedding results, we then prove (global) Hardy-Sobolev inequalities and also fractional versions of such inequalities in the setting of metric spaces.
Subtype selective binding properties of substituted linear melanocyte stimulating hormone analogues
2002
The melanocortin receptors are peptide binding G-protein coupled receptors that play a role in important physiological functions such as energy balance, inflammatory processes and several aspects of reproduction. In this study, we synthesised 11 new linear MSH analogues and tested their binding to the human MC receptors (MC1, MC3, MC4 and MC5) expressed in COS cells. Our results show that introduction of Asp in position 4 similarly affects the binding to the MC1, MC4 and MC5 receptors, but drastically lowers the binding to the MC3 receptor. Arg(5) substitution shows relatively high affinity for the MC4 receptor, while the results also give further support for specific importance of His(6) f…