Search results for "610"

Isotopic Anthropology of Rural German Medieval Diet: Intra- and Inter-population Variability

2016

This study investigates the diet of an eleventh century CE parish community located in northwestern Germany. We assessed the isotopic compositions of human (n = 24) and faunal (n = 17) bone collagen (δ 13Ccol, δ 15Ncol) and human structural carbonate (δ 13Csc) using skeletal material recovered from the Dalheim cemetery. Traditional interpretation of the isotopic data indicates that Dalheim residents likely relied on a C3 plant-based diet and consumed some terrestrial animal products without evidence of marine resource input in the diet. Bivariate and multivariate models used as an additional means to assess diet indicate minor consumption of C4 plant foods in this community. The multivariat…

Evolution of the Globin Gene Family in Deuterostomes: Lineage-Specific Patterns of Diversification and Attrition

2012

In the Metazoa, globin proteins display an underlying unity in tertiary structure that belies an extraordinary diversity in primary structures, biochemical properties, and physiological functions. Phylogenetic reconstructions can reveal which of these functions represent novel, lineage-specific innovations, and which represent ancestral functions that are shared with homologous globin proteins in other eukaryotes and even prokaryotes. To date, our understanding of globin diversity in deuterostomes has been hindered by a dearth of genomic sequence data from the Ambulacraria (echinoderms + hemichordates), the sister group of chordates, and the phylum Xenacoelomorpha, which includes xenoturbel…

Los primeros grados de la Universidad de Orihuela (1610-1643)

2017

Relaciones entre la monarquía Hispánica y el reino de Galicia: el papel de los Diputados Generales del Reino

2020

Oligarquización, oligarquías y gobierno urbano en el Oviedo de los Austrias

2020

El sentimiento de superioridad de los jesuitas tras la extinción de la Compañía de Jesús

2020

Construcción de puentes y avenidas fluviales: algunos debates técnicos en el academicismo ilustrado del Reino de Valencia

2020

Con el afianzamiento de las políticas reformistas y la consolidación de las academias de bellas artes, durante el último tercio del siglo XVIII se desarrolló una creciente polémica entre los arquitectos y los maestros de obra en torno a la proyección y diseño de obra civil, particularmente la relacionada con ambientes fluviales. En este artículo se valora, con diferentes ejemplos, la incidencia de este debate en la proyección de puentes y su capacidad de resistencia a las avenidas fluviales. During the last third of the 18th century, reformist policies and the consolidation of the fine arts academies were consolidated. This fact affected the architects and the master builders with a policy …

Ferrer del Río: Rodrigo de Mendoza, noble y coleccionista del Renacimiento

2020

Injury-activated glial cells promote wound healing of the adult skin in mice

2018

Cutaneous wound healing is a complex process that aims to re-establish the original structure of the skin and its functions. Among other disorders, peripheral neuropathies are known to severely impair wound healing capabilities of the skin, revealing the importance of skin innervation for proper repair. Here, we report that peripheral glia are crucially involved in this process. Using a mouse model of wound healing, combined with in vivo fate mapping, we show that injury activates peripheral glia by promoting de-differentiation, cell-cycle re-entry and dissemination of the cells into the wound bed. Moreover, injury-activated glia upregulate the expression of many secreted factors previously…

Cognate HLA absence in trans diminishes human NK cell education

2016

NK cells are innate lymphocytes with protective functions against viral infections and tumor formation. Human NK cells carry inhibitory killer cell Ig-like receptors (KIRs), which recognize distinct HLAs. NK cells with KIRs for self-HLA molecules acquire superior cytotoxicity against HLA– tumor cells during education for improved missing-self recognition. Here, we reconstituted mice with human hematopoietic cells from donors with homozygous KIR ligands or with a mix of hematopoietic cells from these homozygous donors, allowing assessment of the resulting KIR repertoire and NK cell education. We found that co-reconstitution with 2 KIR ligand–mismatched compartments did not alter the frequenc…