Search results for "616"

Morphological alterations in the hippocampus of the Ts65Dn mouse model for Down syndrome correlate with structural plasticity markers

2018

Down syndrome (DS) is the most common chromosomal aneuploidy. Although trisomy on chromosome 21 can display variable phenotypes, there is a common feature among all DS individuals: the presence of intellectual disability. This condition is partially attributed to abnormalities found in the hippocampus of individuals with DS and in the murine model for DS, Ts65Dn. To check if all hippocampal areas were equally affected in 4-5 month adult Ts65Dn mice, we analysed the morphology of dentate gyrus granule cells and cornu ammonis pyramidal neurons using Sholl method on Golgi-Cox impregnated neurons. Structural plasticity has been analysed using immunohistochemistry for plasticity molecules follow…

Timing and patterns of the ENSO signal in Africa over the last 30 years: insights from normalized difference vegetation index data.

2014

Abstract A more complete picture of the timing and patterns of the ENSO signal during the seasonal cycle for the whole of Africa over the three last decades is provided using the normalized difference vegetation index (NDVI). Indeed, NDVI has a higher spatial resolution and is more frequently updated than in situ climate databases, and highlights the impact of ENSO on vegetation dynamics as a combined result of ENSO on rainfall, solar radiation, and temperature. The month-by-month NDVI–Niño-3.4 correlation patterns evolve as follows. From July to September, negative correlations are observed over the Sahel, the Gulf of Guinea coast, and regions from the northern Democratic Republic of Congo…

Language: A Challenging Resource in a Museum of Sámi Culture

2015

Choices made around using language in museums can either reinforce or challenge existing common sense language regimes and cultural hegemonies. The issues around linguistic choices are particularly pronounced for a museum of indigenous culture in a multilingual minority language community. Using the case of the Siida, the National Museum of the Finnish Sami, located in Inari, in Finnish Samiland, we explore some of the issues involved in using language in the museum. Based on a linguistic landscape analysis, we identify three main functions of language in the museum: managing and controlling visitors; narrating and explaining content and being displayed as content/exhibit. We discuss these …

Expert appraisal of criteria for assessing gaming disorder: An international Delphi study

2021

Background and aims Following the recognition of ‘internet gaming disorder’ (IGD) as a condition requiring further study by the DSM‐5, ‘gaming disorder’ (GD) was officially included as a diagnostic entity by the World Health Organization (WHO) in the eleventh revision of the International Classification of Diseases (ICD‐11). However, the proposed diagnostic criteria for gaming disorder remain the subject of debate, and there has been no systematic attempt to integrate the views of different groups of experts. To achieve a more systematic agreement on this new disorder, this study employed the Delphi expert consensus method to obtain expert agreement on the diagnostic validity, clinical util…

Neuroinflammation by cytotoxic T-lymphocytes impairs retrograde axonal transport in an oligodendrocyte mutant mouse.

2012

Mice overexpressing proteolipid protein (PLP) develop a leukodystrophy-like disease involving cytotoxic, CD8+ T-lymphocytes. Here we show that these cytotoxic T-lymphocytes perturb retrograde axonal transport. Using fluorogold stereotactically injected into the colliculus superior, we found that PLP overexpression in oligodendrocytes led to significantly reduced retrograde axonal transport in retina ganglion cell axons. We also observed an accumulation of mitochondria in the juxtaparanodal axonal swellings, indicative for a disturbed axonal transport. PLP overexpression in the absence of T-lymphocytes rescued retrograde axonal transport defects and abolished axonal swellings. Bone marrow tr…

School teachers bullied by their students: Teachers´ attributions and how they share their experiences

2012

Abstract Previous studies suggest that many teachers worldwide are bullied by students. However, deeper understanding of teachers' bullying experiences; of their interpretations of the causes of bullying; and of how they cope with these experiences, is lacking. Using an Internet survey we examined the attributions made by Finnish elementary and lower secondary school teachers for their victimisation; the people with whom they share their experiences; and the links between these. Three kinds of attribution were identified: student-related, institution-related, and teacher-related. Selection of the persons with whom teachers shared their experiences was determined by the nature of the attribu…

Identificación del gen MALT1 como oncogén dominante en el linfoma MALT.

2005

En los linfomas no Hodgkin (LNH), las traslocaciones primarias características dan lugar a la desregulación de un protooncogén (debido en un gran número de casos al reordenamiento con el gen de las inmunoglobulinas) y cuya consecuencia funcional es la alteración de la expresión génica con potencial neoplásico. Otro tipo de lesión genética frecuente es la delección cromosómica que inactiva genes supresores tumorales, por ejemplo p53 ó p16. Estas anomalías se identifican junto a las traslocaciones primarias y se consideran alteraciones secundarias relacionadas con la progresión y transformación tumoral. También la amplificación génica es otro mecanismo de reordenamiento molecular frecuente en…

Hamlet : tragedia de Guillermo Shakespeare

Grav. calc. en f. de làm.: "Giuseppe Cades inv. e del. Gio. Batta Leonetti incise" Text a 1 col Sign.: 1-53(4), 54(3). - Cuaderns numerats

Study design of Heart failure Events reduction with Remote Monitoring and eHealth Support (HERMeS)

2020

Aims: The role of non‐invasive telemedicine (TM) combining telemonitoring and teleintervention by videoconference (VC) in patients recently admitted due to heart failure (HF) (‘vulnerable phase’ HF patients) is not well established. The aim of the Heart failure Events reduction with Remote Monitoring and eHealth Support (HERMeS) trial is to assess the impact on clinical outcomes of implementing a TM service based on mobile health (mHealth), which includes remote daily monitoring of biometric data and symptom reporting (telemonitoring) combined with VC structured, nurse‐based follow‐up (teleintervention). The results will be compared with those of the comprehensive HF usual care (UC) strateg…

Morality in Let’s Play narrations : Moral evaluations of Gothic monsters in gameplay videos of Fallout 3

2018

Performative Let’s Play gaming videos are a part of contemporary Internet culture through which morality becomes shared. Many digital games draw on Gothic traditions to feature human-like monsters who demand morally complex interpretations from players. This study examines what kinds of moral evaluations players form of ambiguous Gothic monsters in Let’s Play videos of the action role-playing game Fallout 3. With a discourse analysis of transcribed speech obtained from 20 Let’s Play series on YouTube, it argues that the moral evaluations that players actively produce impact significantly on the play experience, that players take diverse moral stances whose (in)determinacy varies based on w…