Search results for "61"
showing 10 items of 3634 documents
The catalytic activity of the endoplasmic reticulum-resident protein microsomal epoxide hydrolase towards carcinogens is retained on inversion of its…
1996
Diol epoxides formed by the sequential action of cytochrome P-450 and the microsomal epoxide hydrolase (mEH) in the endoplasmic reticulum (ER) represent an important class of ultimate carcinogenic metabolites of polycyclic aromatic hydrocarbons. The role of the membrane orientation of cytochrome P-450 and mEH relative to each other in this catalytic cascade is not known. Cytochrome P-450 is known to have a type I topology. According to the algorithm of Hartman, Rapoport and Lodish [(1989) Proc. Natl. Acad. Sci. U.S.A. 86, 5786–5790], which allows the prediction of the membrane topology of proteins, mEH should adopt a type II membrane topology. Experimentally, mEH membrane topology has been …
Māwardī and Machiavelli : Reflections on Power in their Mirrors for Princes
2018
Abstract Despite their apparently contradictory views on religion’s role in statecraft, and despite being separated by both history and geography, Al-Mawardi and Machiavelli approach the question of political power in an unapologetically direct fashion. This paper interrogates their philosophies and the way in which their highly unstable social settings and their rather more stable religious traditions intersect in two of their key texts, The Ordinances of Government and The Prince, respectively. These texts demonstrate that even early Muslim tradition had a theory of impersonal governance, whereas 500 years later Europeans had by no means given up on narratives of personified power.
The Role of Marketing Tools in the Improvement of Consumers Financial Literacy
2015
Abstract The aim of the paper is to explore the contribution of different types of marketing communication in consumer financial literacy formation from a three component perspective. As a method a survey among the target audience of home loans was used. The authors have focused on consumer financial knowledge, financial behaviour and financial attitude that constitute financial literacy in home loan market. As a result of empirical analysis the authors have found that the biggest contribution to formation of consumers financial literacy (within all three components) have educational web sites of government authorities, official web sites of banks, consultations with bank specialists, schoo…
The Risk Society: Towards a new modernity
2009
The present review discusses one of the pioneer projects authored by Ulrich Beck, regarding risk perception issues, which was originally titled Risikogesellshaft, Auf dem weg in eine andere Moderne or in English The society of risk, towards a new modernity. This review is part of a broader project related to a Social Psychology doctoral thesis on fears of travelling in urban circumstances.
Protective role of the complement regulatory protein human CD-55 in cardiac xenograft: a descriptive study and a revision of the literature.
2002
The limited and inadequate availability of organs from human donors has resulted in the utilisation of xenografts as an alternative tool. Nevertheless, hyperacute rejection (HAR) following xenograft determines the loss of the transplanted organ. The “primum movens” is the activation of the complement pathway mediated by the binding of natural xenogenic antibodies to the endothelium of the graft, followed by the lysis of the endothelial cells with subsequent oedema, thrombosis and necrosis of the transplanted organ. In this work we describe morphological and biomolecular observations of isolated human-decay accelerating factor (h-DAF, CD55) transgenic pig hearts, after perfusion for four hou…
Offspring microbiomes differ across breeding sites in a panmictic species.
2019
High dispersal rates are known to homogenize host’s population genetic structure in panmictic species and to disrupt host local adaptation to the environment. Long-distance dispersal might also spread micro-organisms across large geographical areas. However, so far, to which extent selection mechanisms that shape host’s population genetics are mirrored in the population structure of the enteric microbiome remains unclear. High dispersal rates and horizontal parental transfer may homogenize bacterial communities between breeding sites (homogeneous hypothesis). Alternatively, strong selection from the local environment may differentiate bacterial communities between breeding sites (heterogene…
Dysphonien bei Kindern – Teil 1
2015
Hintergrund: Uber die Behandlung von Dysphonien im Kindesalter gibt es international aktuell keinen Konsens und keine Leitlinie. Zudem differieren die in verschiedenen Publikationen vertretenen Auffassungen uber Ursachen, Entwicklung und Pravalenzen stark. Ziel: Ziel der vorliegenden Arbeit war es deshalb, einen interdisziplinaren Konsens bezuglich der Pathogenese, Atiologie und Auswirkungen von Stimmstorungen bei Kindern herbeizufuhren. Methodik: Nominaler Gruppenprozess, interdisziplinarer Erfahrungsaustausch, Literaturrecherche und Evidenzlevelbewertung von Publikationen zu Ursachen, Haufigkeiten, Entstehung und Entwicklung von Dysphonien bei Kindern und Jugendlichen. Ergebnisse: Die aus…
Luftverschmutzung als wichtiger Kofaktor bei COVID-19-Sterbefällen
2021
Zusammenfassung Hintergrund Die Sterblichkeit bei COVID-19 ist in Anwesenheit kardiopulmonaler Komorbiditäten erhöht. Luftverschmutzung ist ebenfalls mit einer erhöhten Sterblichkeit assoziiert, v. a. vermittelt durch kardiopulmonale Erkrankungen. Beobachtungen zu Beginn der COVID-19-Pandemie zeigten, dass die Sterblichkeit bei COVID-19 v. a. in Regionen mit stärkerer Luftverschmutzung erhöht ist. Ungeklärt ist der Einfluss von Luftverschmutzung für den Krankheitsverlauf bei COVID-19. Methode Es wurde eine selektive Literaturrecherche von Studien bis Anfang April 2021 in PubMed zum Zusammenhang von Luftverschmutzung und der COVID-19-Mortalität mit den Suchbegriffen „air pollution AND/OR COV…
Veränderung des Schmeckvermögens bei Patienten mit Vestibularisschwannom
2014
Das Vestiularisschwannom ist ein gutartiger Tumor. Klinisch wird die Erkrankung durch die Kardinalsymptome einseitige Hörminderung, Tinnitus und Gleichgewichtsstörungen auffällig. Auf Grund der anatomischen Enge im Bereich des inneren Gehörganges kann es auch zu Affektionen des N.[for full text, please go to the a.m. URL]
Agroecological engineering
2015
Earth has recently entered the new era of the Anthropocene, during which the rise of human activities are impacting for the first time ecosystems and climate on the global scale. Since the 1960s the green revolution has improved food production in quantity using industrially-designed agriculture, which has led to global pollution by pesticides and losses of food quality, biodiversity and soil carbon. As a consequence there is a need to implement agroecological practices in order to produce food safely and in a sustainable way. This virtual issue presents principles and applications of agroecological engineering, exemplified in 19 selected review articles from the journal Agronomy for Sustai…