Search results for "61"
showing 10 items of 3634 documents
Toward a holistic understanding of pastoralism
2021
Pastoralism is globally significant in social, environmental, and economic terms. However, it experiences crises rooted in misconceptions and poor interdisciplinary understanding, while being largely overlooked in international sustainability forums and agendas. Here, we propose a transdisciplinary research approach to understand pastoralist transitions using (1) social, economic, and environmental dimensions, (2) diverse geographic contexts and scales to capture emerging properties, allowing for cross-system comparisons, and (3) timescales from the distant past to the present. We provide specific guidelines to develop indicators for this approach, within a social-ecological resilience anal…
Sepsis at ICU admission does not decrease 30-day survival in very old patients : a post-hoc analysis of the VIP1 multinational cohort study
2020
AbstractBackgroundThe number of intensive care patients aged ≥ 80 years (Very old Intensive Care Patients; VIPs) is growing. VIPs have high mortality and morbidity and the benefits of ICU admission are frequently questioned. Sepsis incidence has risen in recent years and identification of outcomes is of considerable public importance. We aimed to determine whether VIPs admitted for sepsis had different outcomes than those admitted for other acute reasons and identify potential prognostic factors for 30-day survival.ResultsThis prospective study included VIPs with Sequential Organ Failure Assessment (SOFA) scores ≥ 2 acutely admitted to 307 ICUs in 21 European countries. Of 3869 acutely admi…
Literacy skills seem to fuel literacy enjoyment, rather than vice versa
2023
Children who like to read and write tend to be better at it. This association is typically interpreted as enjoyment impacting engagement in literacy activities, which boosts literacy skills. We fitted direction-of-causation models to partial data of 3690 Finnish twins aged 12. Literacy skills were rated by the twins' teachers and literacy enjoyment by the twins themselves. A bivariate twin model showed substantial genetic influences on literacy skills (70%) and literacy enjoyment (35%). In both skills and enjoyment, shared-environmental influences explained about 20% in each. The best-fitting direction-of-causation model showed that skills impacted enjoyment, while the influence in the othe…
Genome-wide meta-analysis identifies six novel loci associated with habitual coffee consumption
2015
Contains fulltext : 155360.pdf (Publisher’s version ) (Closed access) Coffee, a major dietary source of caffeine, is among the most widely consumed beverages in the world and has received considerable attention regarding health risks and benefits. We conducted a genome-wide (GW) meta-analysis of predominately regular-type coffee consumption (cups per day) among up to 91,462 coffee consumers of European ancestry with top single-nucleotide polymorphisms (SNPs) followed-up in ~30 062 and 7964 coffee consumers of European and African-American ancestry, respectively. Studies from both stages were combined in a trans-ethnic meta-analysis. Confirmed loci were examined for putative functional and b…
Modeling the mixed-morphology supernova remnant IC 443. Origin of its complex morphology and X-ray emission
2020
The morphology and the distribution of material observed in SNRs reflect the interaction of the SN blast wave with the ambient environment, the physical processes associated with the SN explosion and the internal structure of the progenitor star. IC 443 is a MM SNR located in a quite complex environment: it interacts with a molecular cloud in the NW and SE areas and with an atomic cloud in the NE. In this work we aim at investigating the origin of the complex morphology and multi-thermal X-ray emission observed in SNR IC 443, through the study of the effect of the inhomogeneous ambient medium in shaping its observed structure, and the exploration of the main parameters characterizing the re…
The Concept of Love in Masculinist Blogs : A Strategic Ideal
2018
Love is often considered a positive emotion and an ethical relationship between people. The representations of love in contemporary culture usually emphasise its beneficial, even empowering effects. However, the fluidity of the concept also enables other kinds of representations of love to flourish. For example, the advocates of traditional gender order — masculinists or male rights activists (MRAs)-— use idealistic images of heterosexual love, often intertwined with the idealised heterosexual nuclear family, to promote repressive ideologies such as misogyny and antifeminism. This is increasingly done with the help of internet sites. In this chapter I wish to show that the fluidity of the c…
An integrative approach to unravel the Ceratitis FAR (Diptera, Tephritidae) cryptic species complex: a review
2015
Abstract This paper reviews all information gathered from different disciplines and studies to resolve the species status within the Ceratitis FAR (Ceratitis fasciventris, Ceratitis anonae, Ceratitis rosa) complex, a group of polyphagous fruit fly pest species (Diptera, Tephritidae) from Africa. It includes information on larval and adult morphology, wing morphometrics, cuticular hydrocarbons, pheromones, microsatellites, developmental physiology and geographic distribution. The general consensus is that the FAR complex comprises Ceratitis anonae, two species within Ceratitis rosa (so-called R1 and R2) and two putatitve species under Ceratitis fasciventris. The information regarding the lat…
Impaired Binding to Junctophilin-2 and Nanostructural Alteration in CPVT Mutation
2021
Rationale: Catecholaminergic polymorphic ventricular tachycardia (CPVT) is a rare disease, manifested by syncope or sudden death in children or young adults under stress conditions. Mutations in the Ca 2+ release channel/RyR2 (type 2 ryanodine receptor) gene account for about 60% of the identified mutations. Recently, we found and described a mutation in RyR2 N-terminal domain, RyR2 R420Q . Objective: To determine the arrhythmogenic mechanisms of this mutation. Methods and Results: Ventricular tachycardias under stress conditions were observed in both patients with catecholaminergic polymorphic ventricular tachycardia and knock-in mice. During action potential recording (by patch-clamp in …
Benchmarking Wilms’ tumor in multisequence MRI data: why does current clinical practice fail? Which popular segmentation algorithms perform well?
2019
Wilms' tumor is one of the most frequent malignant solid tumors in childhood. Accurate segmentation of tumor tissue is a key step during therapy and treatment planning. Since it is difficult to obtain a comprehensive set of tumor data of children, there is no benchmark so far allowing evaluation of the quality of human or computer-based segmentations. The contributions in our paper are threefold: (i) we present the first heterogeneous Wilms' tumor benchmark data set. It contains multisequence MRI data sets before and after chemotherapy, along with ground truth annotation, approximated based on the consensus of five human experts. (ii) We analyze human expert annotations and interrater varia…
[Breu, 1661, 12, 08]
1662
Inclou el Breve d'Alexandre VII datat en Roma el 8 de Decembre de 1661 Grav. xil. enamrcat de l'Immaculada, flanquejat per dos escuts, papal i reial Caplletra ornada Sign.: [ ]2 Reclams