Search results for "63"
showing 10 items of 724 documents
Historia del capitulo General, que celebro la Religion Serafica en la Imperial Toledo este año de 1633 y Accion de gracias de la Religion â Dios N.…
1633
Grab. calc. amb els esc. de Francesco Barberini a qui es dedica l'obra: "I. de Courbes F", en p. [4 Port. a 2 tintes Sign.: [ ]2, œ4, [ ]1, A-V4, a-h4. - Errates tip. en la fol.
La basílica de santa María de Elche: proyecto clasicista en la arquitectura del siglo XVII
2020
La basílica de santa María de Elche se construyó en un dilatado periodo de tiempo (1673-1784), si bien la totalidad de su fábrica es deudora de la concepción del proyecto original. Este fue elaborado por el arquitecto Francisco Verde, siendo continuado por Pedro Quintana y rediseñado por Juan Fauquet. En este artículo se explora dicho proyecto en el marco de la arquitectura seiscentista, así como se aporta documentación inédita sobre los primeros años de construcción y sus artífices. The church of Santa Maria (Elche) was built on a lengthy period of time, although the construction is based on the conception of the original project, designed by the architect Francisco Verde, continued by Ped…
Role of Human Sec63 in Modulating the Steady-State Levels of Multi-Spanning Membrane Proteins
2012
The Sec61 translocon of the endoplasmic reticulum (ER) membrane forms an aqueous pore, allowing polypeptides to be transferred across or integrated into membranes. Protein translocation into the ER can occur co- and posttranslationally. In yeast, posttranslational translocation involves the heptameric translocase complex including its Sec62p and Sec63p subunits. The mammalian ER membrane contains orthologs of yeast Sec62p and Sec63p, but their function is poorly understood. Here, we analyzed the effects of excess and deficit Sec63 on various ER cargoes using human cell culture systems. The overexpression of Sec63 reduces the steady-state levels of viral and cellular multi-spanning membrane …
p63 Isoforms Regulate Metabolism of Cancer Stem Cells
2014
p63 is an important regulator of epithelial development expressed in different variants containing (TA) or lacking (ΔN) the N-terminal transactivation domain. The different isoforms regulate stem-cell renewal and differentiation as well as cell senescence. Several studies indicate that p63 isoforms also play a role in cancer development; however, very little is known about the role played by p63 in regulating the cancer stem phenotype. Here we investigate the cellular signals regulated by TAp63 and ΔNp63 in a model of epithelial cancer stem cells. To this end, we used colon cancer stem cells, overexpressing either TAp63 or ΔNp63 isoforms, to carry out a proteomic study by chemical-labeling …
Ploidy manipulation and citrus breeding, genetics and genomics
2020
Polyploidy appears to have played a limited role in citrus germplasm evolution. However, today, ploidy manipulation is an important component of citrus breeding strategies. For varieties, the main objective is to develop triploid seedless cultivars. For rootstock, the aim is to cumulate interesting traits in tetraploid hybrids and to improve adaptation to biotic and abiotic stresses. This chapter starts with a review of the recent knowledge acquired on the natural mechanisms of citrus polyploidization and tetraploid meiosis. Chromosome doubling of nucellar cells is frequent in apomictic citrus and results in tetraploid seedling production. Unreduced gametes are also frequently produced, mai…
The relationship between the level of physical activity, independence in daily activities, and life quality and satisfaction in women over 80 living …
2020
Wprowadzenie. Rosnący poziom opieki zdrowotnej stale zwiększa długość życia ludzi. Rosnąca liczba osób starszych i zaburzenie równowagi w strukturze populacji wpłynie na wiele dziedzin życia, w tym na system ubezpieczeń społecznych, orientację zawodową osób pracujących czy kulturę. Dlatego bardzo ważne jest, aby osoby starsze zachowały nie tylko dobre zdrowie fizyczne, ale także utrzymywały zdolność do samoopieki tak długo, jak to możliwe, pozostały sprawne funkcjonalnie i wyrażały zadowolenie z życia we wszystkich dziedzinach. Cel. Niniejsze badanie ma na celu analizę czynników wpływających na jakość życia w różnych dziedzinach (fizyczna, psychologiczna, społeczna i środowiskowa), takich j…
Experiences of Female Breast Cancer Survivors Concerning Their Return to Work in Spain
2021
The objective of this study was to analyze the experiences of returning to work of women who had overcome breast cancer, identifying its physical and psychological consequences, the process they underwent, their motivations, and difficulties. A total of 19 female breast cancer survivors, with an age range of 30 to 57 years, participated in two focus groups. A semi-structured script was prepared about their experiences of returning to work. The results indicated that survivors’ self-perception was weakened by the physical and psychological consequences of the treatment of the disease
Analyzing structural change : the biproportional mean filter and the biproportional bimarkovian filter
1998
The biproportional filter was created to analyze structural change between two input-output matrices by removing the effect of differential growth of sectors without predetermining if the model is demand or supply-driven, but with the disadvantage that projecting a first matrix on a second is not the same thing than projecting the second matrix on the first. Here two alternative methods are proposed which has not this last drawback, with the additional advantage for the biproportional bimarkovian filter that effects of sector size are also removed. Methods are compared with an application for France for 1980 and 1996.
Oratio ad Sacrosanctum Oecumenicum Concilium Tridentinum, qua de ecclesiae auctoritate, et imitandis apostolis disseritur habita per... Gasparem A' F…
1563
Sign.: A4, B2
A survey and comparison of transformation tools based on the transformation tool contest
2014
Model transformation is one of the key tasks in model-driven engineering and relies on the efficient matching and modification of graph-based data structures; its sibling graph rewriting has been used to successfully model problems in a variety of domains. Over the last years, a wide range of graph and model transformation tools have been developed – all of them with their own particular strengths and typical application domains. In this paper, we give a survey and a comparison of the model and graph transformation tools that participated at the Transformation Tool Contest 2011. The reader gains an overview of the field and its tools, based on the illustrative solutions submitted to a Hello…