Search results for "70"
showing 10 items of 9933 documents
Examining the generalizability of research findings from archival data
2022
This research project benefitted from Ministry of Education (Singapore) Tier 1 Grant R-313-000-131-115 (to A. Delios), National Science Foundation of China Grants 72002158 (to H.T.) and 71810107002 (to H.T.), grants from the Knut and Alice Wallenberg Foundation (to A. Dreber) and the Marianne and Marcus Wallenberg Foundation (through a Wallenberg Scholar grant; to A. Dreber), Austrian Science Fund (FWF) Grant SFB F63 (to A. Dreber), grants from the Jan Wallander and Tom Hedelius Foundation (Svenska Handelsbankens Forskningsstiftelser; to A. Dreber), and an Research & Development (R&D) research grant from Institut Européen d'Administration des Affaires (INSEAD) (to E.L.U.). Dmitrii Dubrov, o…
Political community resilience in declining rural areas in Finland
2021
Abstract In this article, we study how declining rural communities build political resilience in Finland. Community resilience is an adaptive process through which rural communities try to maintain their viability in changed circumstances. This process does not entail a submissive attitude, but rather active agency and an effort to influence matters concerning the community’s well-being. We focus on the political dimension of resilience by identifying different local tactics that rural communities adopt to promote their own development following municipal mergers. We classify these tactics into three categories: cooperation, conflict and community-led development. The significant difference…
Optimal Resource Allocation in Multi-Hop Networks: Contention vs. Scheduling
2014
CSMA/CA (Carrier Sense Multiple Access/Collision Avoidance) is actually the most used method in ad-hoc networks for transmitting on a contending medium, even if it shows poor performance in presence of hidden nodes. To increase performance, we propose an algorithm that combines CSMA and TDMA (Time Division Multiple Access) approaches. The adopted solution consists of grouping contending nodes in non-interfering subsets and granting a different numbers of time slots to different groups, while using the CSMA to manage medium access among nodes belonging to the same subset. An optimization procedure to assign the time slots to each subset of nodes and to find an equilibrium between contention …
Expired Tidal Volume and Respiratory Rate During Postnatal Stabilization of Newborn Infants Born at Term via Cesarean Delivery
2021
Objective To retrieve evolving respiratory measures in the first minutes after birth in normal neonates born at term using a respiratory function monitor. Study design We evaluated newborn babies delivered at term via cesarean after uncomplicated pregnancies. Immediately after birth, a respiratory function monitor with an adapted flowmeter and a face mask were applied at 2, 5, and 10 minutes after birth for 90 seconds in each period. We analyzed expired and inspired tidal volume, respiratory rate (RR), percentage of leakage, and number of analyzed breaths in each individual infant's recording using a respiratory research software. Results A total of 243 infants completed the study. The fina…
Effects of E-Cigarette Exposure on Prenatal Life and Childhood Respiratory Health: A Review of Current Evidence
2021
In the last decade, widespread use of E-cigarettes (EC) has occurred all over the world. Whereas, a large amount of evidence on harm to children from conventional cigarette exposure is available, data on health effects in this population throughout different vulnerability windows are still a matter of concern. Exposure to EC during pregnancy may compromise placental function, resulting in fetal structural abnormalities. Specifically, this may cause physio-pathologic changes in the developing lung, which in turn may impair respiratory health later in life. Furthermore, there is evidence that using EC can cause both short- and long-term respiratory problems in the pediatric population and the…
Photoinduced lethal and sublethal toxicity of retene, a polycyclic aromatic hydrocarbon derived from resin acid, to coregonid larvae
2004
A comparative investigation on the acute phototoxicity of retene to vendace (Coregonus albula) and whitefish (C. lavaretus), both having pelagial larvae in spring, was conducted. To test the concept of early warning of sublethal biomarkers in relation to lethality to posthatch stages, we examined the effects of ultraviolet-B (UV-B) and retene on the levels of cytochrome P4501A (CYP1A) and heat shock protein 70 (HSP70) by exposing the animals to elevated levels of these factors for 48 and 72 h, respectively. Whereas UV-B and retene on their own were not lethal, simultaneous retene and UV-B exposure caused very high mortality to both species. The median lethal concentration (LC50; i.e., the c…
Regulation of the HTRA2 Protease Activity by an Inhibitory Antibody-Derived Peptide Ligand and the Influence on HTRA2-Specific Protein Interaction Ne…
2021
The mitochondrial serine protease HTRA2 has many versatile biological functions ranging from being an important regulator of apoptosis to being an essential component for neuronal cell survival and mitochondrial homeostasis. Loss of HTRA2 protease function is known to cause neurodegeneration, whereas overactivation of its proteolytic function is associated with cell death and inflammation. In accordance with this, our group verified in a recent study that the synthetic peptide ASGYTFTNYGLSWVR, encoding the hypervariable sequence part of an antibody, showed a high affinity for the target protein HTRA2 and triggered neuroprotection in an in vitro organ culture model for glaucoma. To unravel t…
Deep sequencing of the human retinae reveals the expression of odorant receptors
2017
Several studies have demonstrated that the expression of odorant receptors (ORs) occurs in various tissues. These findings have served as a basis for functional studies that demonstrate the potential of ORs as drug targets for a clinical application. To the best of our knowledge, this report describes the first evaluation of the mRNA expression of ORs and the localization of OR proteins in the human retina that set a stage for subsequent functional analyses. RNA-Sequencing datasets of three individual neural retinae were generated using Next-generation sequencing and were compared to previously published but reanalyzed datasets of the peripheral and the macular human retina and to reference…
Retinal abnormalities in multiple sclerosis patients with associated chronic cerebrospinal venous insufficiency
2012
Optical coherence tomography (OCT) is a non-invasive method for the assessment of optic nerve fibers and retinal ganglion cells. This study was aimed at the assessment of retinal abnormalities in multiple sclerosis patients in the context of chronic cerebrospinal venous insufficiency using OCT of the retina and the optic nerve. We examined 239 multiple sclerosis (MS) patients, including 220 patients with associated chronic cerebrospinal venous insufficiency and 19 MS patients without venous pathology. The following OCT parameters were assessed: average ganglion cell complex thickness, global loss volume, focal loss volume and average retinal nerve fibre layer thickness. Abnormalities in the…
Innovazione sociale e creatività. Nuovi scenari di sviluppo per il territorio sicano
2018
Innovazione sociale e creatività. Nuovi scenari di sviluppo per il territorio sicano, attraverso il paradigma emergente della Circular Land e alcune esperienze d'innovazione locale in Sicilia, traccia un nuovo scenario di sviluppo in Sicilia, evidenziando le relazioni tra l'innovazione sociale, quale processo territorialmente radicato e il contesto spaziale in cui agisce, e identificando nella dimensione relazionale della connettività il principale campo d'azione per le politiche territoriali regionali. In the contribution Innovation and creativity. New development scenarios for the Sicani area, starting from the emerging concept of Circular Land and from some experiences of local innovatio…