Search results for "75"
showing 10 items of 1365 documents
Development and in vitro Evaluation of Antigen-Loaded Poly(amidoamine) Nanoparticles for Respiratory Epithelium Applications
2013
A poly(amidoamine) with disulfide linkages in the main chain and 4-hydroxybutyl and ω-carboxy-PEG groups (9:1 ratio) as side chains was prepared by Michael addition polymerization of cystamine bisacrylamide with 4-hydroxybutylamine and ω-carboxy-PEG-amine. To develop therapeutic protein formulations for improved delivery of antigen via the intranasal route, nanoparticles were prepared from this polymer by self-assembly with p24 or ovalbumin as the model proteins and CpG as the adjuvant. The nanoparticles incorporated the antigens and adjuvant from the feed solution with high efficiency (∼90 %) and have sizes of 112 and 169 nm, respectively, with low positive surface charge (∼+2 mV). Formula…
"Un puente sobre el abismo", de Higinio Noja Ruiz (1932) : cultura libertaria y literatura pacifista de entreguerras
2021
El escritor, ensayista y militante anarquista Higinio Noja Ruiz publicó en 1932 la novela Un puente sobre el abismo en la Editorial Estudios de Valencia. En ella Noja abordó el tema de las guerras y la lucha contra ellas a través de su protagonista, Guillermo Arjona, un joven burgués mallorquín muy influido por su lectura de las novelas sobre la Primera Guerra Mundial y casi obsesionado con esta temática. Se analiza aquí en primer lugar la figura de Noja Ruiz (1994-1972), prolífico novelista social a la vez que ensayista y pensador libertario de las décadas de 1920 y 1930. La trayectoria de Noja es inseparable de la de la revista cultural y editorial libertaria valenciana Estudios (1928-193…
Polar bosons in one-dimensional disordered optical lattices
2013
We analyze the effects of disorder and quasi-disorder on the ground-state properties of ultra-cold polar bosons in optical lattices. We show that the interplay between disorder and inter-site interactions leads to rich phase diagrams. A uniform disorder leads to a Haldane-insulator phase with finite parity order, whereas the density-wave phase becomes a Bose-glass at very weak disorder. For quasi-disorder, the Haldane insulator connects with a gapped generalized incommesurate density wave without an intermediate critical region.
Synthesis, chemical characterization and preliminary in vitro antitumor activity evaluation of new ruthenium(II) complexes with sugar derivatives
2011
Abstract Three new complexes of Ru(II), namely [RuCl 2 (Glun-N,O) 2 ]Na 2 ( I ; Glun = glucosaminate), [RuCl 2 (1-Tglu)(EtOH) 2 ]Na ( II ; 1-Tglu = 1-thio-β- d -glucose) and [Ru 2 (EtOH) 6 (AL)Cl 4 ] ( III ; AL = 6′-aminolactose) were prepared from the same Ru(II) precursor, [RuCl 2 (DMSO) 4 ] (DMSO = dimethyl sulfoxide). The characterization of the complexes was carried out by elemental analysis, FT-IR, ES-MS, NMR, EXAFS and DFT calculations. The effectiveness of the complexes on metastatic melanoma A 375 was investigated. The results show that complex II is the most active species.
La continuïtat «bioliterària» al País Valencià: de Carles Ros a Carles Salvador (o de Gregori Maians a Vicent Andrés Estellés, passant per Teodor Llo…
2015
Resum: L’article fa evident un fil conductor que va dels novatores preil·lustrats valencians de la fi del s. XVII fins a l’actualitat. També la connexió directa de València amb Londres i París al segle XIX –no sols amb Cadis, Madrid o Barcelona. Els poemes «En los dies del rei Fernando» d’Antoni Maria Peyrolon (1830) i «Lo somni» de Vicent Salvà (1831) són exponents valencians de cultura avançada. Teodor Llorente és també valorat com l’eix que connecta malgré lui l’esforç cultural dignificador valencià anterior a 1859 –amb l’Escola Pia de València com a focus primigeni de l’evolució romàntica– i l’esforç cultural dignificador valencià posterior a 1909. És a dir, entre la celebració dels Joc…
Sánchez-Montes González, Francisco, Jiménez Estrella, Antonio, Lozano Navarro, Julián J. (editores). El Reino de Granada y la Monarquía Hispánica en …
2021
The Spanish economic Miracle: a disaggregated approach to productivity growth, 1958-1975
2006
En este trabajo se analizan las fuentes del crecimiento español durante 1958-1975 desde una perspectiva sectorial, siguiendo una metodología similar a la desarrollada por Jorgenson, Gollop y Fraumeni (1987). Para ello se mide la contribución de los inputs intermedios, el capital, el trabajo y la productividad total de los factores al crecimiento del output total para 25 ramas productivas. Los resultados atribuyen más de la mitad del crecimiento del output al crecimiento de la Productividad Total de los Factores. Este crecimiento de la productividad fue de alcance general aunque no estuvo uniformemente repartido y se apoyó en una potente contribución de algunas industrias manufactureras comp…
Neuronal cell cycle: the neuron itself and its circumstances.
2015
Neurons are usually regarded as postmitotic cells that undergo apoptosis in response to cell cycle reactivation. Nevertheless, recent evidence indicates the existence of a defined developmental program that induces DNA replication in specific populations of neurons, which remain in a tetraploid state for the rest of their adult life. Similarly, de novo neuronal tetraploidization has also been described in the adult brain as an early hallmark of neurodegeneration. The aim of this review is to integrate these recent developments in the context of cell cycle regulation and apoptotic cell death in neurons. We conclude that a variety of mechanisms exists in neuronal cells for G1/S and G2/M check…
Singular integrals on regular curves in the Heisenberg group
2019
Let $\mathbb{H}$ be the first Heisenberg group, and let $k \in C^{\infty}(\mathbb{H} \, \setminus \, \{0\})$ be a kernel which is either odd or horizontally odd, and satisfies $$|\nabla_{\mathbb{H}}^{n}k(p)| \leq C_{n}\|p\|^{-1 - n}, \qquad p \in \mathbb{H} \, \setminus \, \{0\}, \, n \geq 0.$$ The simplest examples include certain Riesz-type kernels first considered by Chousionis and Mattila, and the horizontally odd kernel $k(p) = \nabla_{\mathbb{H}} \log \|p\|$. We prove that convolution with $k$, as above, yields an $L^{2}$-bounded operator on regular curves in $\mathbb{H}$. This extends a theorem of G. David to the Heisenberg group. As a corollary of our main result, we infer that all …
Dimension estimates for the boundary of planar Sobolev extension domains
2020
We prove an asymptotically sharp dimension upper-bound for the boundary of bounded simply-connected planar Sobolev $W^{1,p}$-extension domains via the weak mean porosity of the boundary. The sharpness of our estimate is shown by examples.